Biocompatible packagings for fully implantable multi-panel devices for remote monitoring of metabolism

This paper compares three different biocompatible packaging covers suitable to support full implantation of multi-panel sensors for remote monitoring of metabolism. The three covers have been designed, realized and implanted in mice for 30 days. ATP and neutrophil concentrations have been measured at the implant site after the device was explanted, to assess the level of biocompatibility of the device.

[1]  Kevin Fu,et al.  Security and Privacy for Implantable Medical Devices , 2008, IEEE Pervasive Comput..

[2]  Franco Maloberti,et al.  Servo-controlled remote powering and low-power data communication of implantable bio-systems for freely moving animals , 2014, 2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings.

[3]  G. De Micheli,et al.  A Subcutaneous Biochip for Remote Monitoring of Human Metabolism: Packaging and Biocompatibility Assessment , 2015, IEEE Sensors Journal.

[4]  J Olivo,et al.  Energy Harvesting and Remote Powering for Implantable Biosensors , 2011, IEEE Sensors Journal.

[5]  Sandro Carrara,et al.  Bio/CMOS Interfaces and Co-Design , 2012 .

[6]  Chris Van Hoof,et al.  Design and Characterization of a Biocompatible Packaging Concept for Implantable Electronic Devices , 2011 .

[7]  Sandro Carrara,et al.  Security and Privacy for Implantable Medical Devices , 2013 .

[8]  Giovanni De Micheli,et al.  Full Fabrication and Packaging of an Implantable Multi-Panel Device for Monitoring of Metabolites in Small Animals , 2014, IEEE Transactions on Biomedical Circuits and Systems.

[9]  Giovanni De Micheli,et al.  Design, fabrication, and test of a sensor array for perspective biosensing in chronic pathologies , 2012, 2012 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[10]  Jae Ho Shin,et al.  Biocompatible materials for continuous glucose monitoring devices. , 2013, Chemical reviews.

[11]  Giovanni De Micheli,et al.  Fully Integrated Biochip Platforms for Advanced Healthcare , 2012, Sensors.