Ferritin/alanine aminotransferase ratio as a possible marker for predicting the prognosis of acute liver injury

Background and Aims:  Serum levels of ferritin and heme oxygenase (HO)‐1 are both markers of macrophage activation. We evaluated simple markers for predicting the prognosis of severe acute liver injury in which macrophage activation plays an important role.

[1]  A. Ido,et al.  Translational research to identify clinical applications of hepatocyte growth factor , 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

[2]  O. Lambotte,et al.  Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome. , 2008, Arthritis and rheumatism.

[3]  William M. Lee,et al.  Soluble CD163 from activated macrophages predicts mortality in acute liver failure. , 2007, Journal of hepatology.

[4]  M. Kurrer,et al.  Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis , 2006, European journal of haematology.

[5]  D. Dormont,et al.  Macrophage activation switching: an asset for the resolution of inflammation , 2005, Clinical and experimental immunology.

[6]  S. Miyagawa,et al.  Expression of Fas Ligand by Hepatic Macrophages in Patients with Fulminant Hepatic Failure , 2005, The American Journal of Gastroenterology.

[7]  R. Jalan.  Gc‐globulin to predict outcome in acute liver failure: A panacea? , 2005, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[8]  A. Choi,et al.  Heme oxygenase-1: from bench to bedside. , 2005, American journal of respiratory and critical care medicine.

[9]  N. Horiike,et al.  Expression of CD163 in the liver of patients with viral hepatitis. , 2005, Pathology, research and practice.

[10]  Shigeru Ohno,et al.  Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia , 2005, Arthritis research & therapy.

[11]  S. Moestrup,et al.  CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response , 2004, Annals of medicine.

[12]  K. Nakahira,et al.  Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. , 2003, Biochemical pharmacology.

[13]  H. Tsutsui,et al.  Cytokine-induced inflammatory liver injuries. , 2003, Current molecular medicine.

[14]  F. Torti,et al.  Regulation of ferritin genes and protein. , 2002, Blood.

[15]  Roger Williams,et al.  The systemic inflammatory response syndrome in acute liver failure , 2000, Hepatology.

[16]  H. Moriwaki,et al.  High levels of serum interleukin-10 and tumor necrosis factor-alpha are associated with fatality in fulminant hepatitis. , 2000, The Journal of infectious diseases.

[17]  H. Ikeda,et al.  Expression of osteopontin in Kupffer cells and hepatic macrophages and Stellate cells in rat liver after carbon tetrachloride intoxication: a possible factor for macrophage migration into hepatic necrotic areas. , 1999, Biochemical and biophysical research communications.

[18]  J. Piette,et al.  Percentage of glycosylated serum ferritin remains low throughout the course of adult onset Still's disease , 1998, Annals of the rheumatic diseases.

[19]  H. Kawasaki,et al.  Serum hepatocyte growth factor levels in liver diseases: Clinical implications , 1995, Hepatology.

[20]  R Williams,et al.  Early indicators of prognosis in fulminant hepatic failure. , 1989, Gastroenterology.

[21]  S. Hirono,et al.  Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure , 1989, Hepatology.

[22]  M. Maines.  Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  N. Esumi,et al.  High serum ferritin level as a marker of malignant histiocytosis and virus‐associated hemophagocytic syndrome , 1988, Cancer.

[24]  S. Eto,et al.  INCREASED SERUM FERRITIN LEVELS IN ADULT STILL'S DISEASE , 1987, The Lancet.

[25]  T. Nakamura,et al.  Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. , 1984, Biochemical and biophysical research communications.

[26]  E. Eastham,et al.  Serum ferritin levels in acute hepatocellular damage from paracetamol overdosage. , 1976, British medical journal.

[27]  S. Sherlock,et al.  Serum ferritin in patients with iron overload and with acute and chronic liver diseases. , 1975, Gastroenterology.

[28]  J. Balow,et al.  GLUCOCORTICOID SUPPRESSION OF MACROPHAGE MIGRATION INHIBITORY FACTOR , 1973, The Journal of experimental medicine.

[29]  H. Marver,et al.  The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[30]  N. Horiike,et al.  Soluble CD163 in patients with liver diseases: very high levels of soluble CD163 in patients with fulminant hepatic failure , 2004, Journal of Gastroenterology.

[31]  J. Neuberger,et al.  Early indicators of prognosis in fulminant hepatic failure: an assessment of the King's criteria. , 1997, Journal of hepatology.

[32]  N. Milman,et al.  Serum ferritin in acute viral hepatitis. , 1984, Scandinavian journal of gastroenterology.

[33]  O. James,et al.  Letter: Pain in gastric ulcer. , 1974, Lancet.