Identification of significant gene biomarkers of low back pain caused by changes in the osmotic pressure of nucleus pulposus cells

[1]  Ruomei Qi,et al.  TPM2 as a potential predictive biomarker for atherosclerosis , 2019, Aging.

[2]  Maree T. Smith,et al.  J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  M. Kazanietz,et al.  CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond , 2019, Front. Endocrinol..

[4]  M. Campos,et al.  Nociceptin/orphanin FQ receptor modulates painful and fatigue symptoms in a mouse model of fibromyalgia. , 2019, Pain.

[5]  Meng Zhang,et al.  Computer-assisted prediction of atherosclerotic intimal thickness based on weight of adrenal gland, interleukin-6 concentration, and neural networks , 2019, The Journal of international medical research.

[6]  Alireza Hadj Khodabakhshi,et al.  Metascape provides a biologist-oriented resource for the analysis of systems-level datasets , 2019, Nature Communications.

[7]  Songran Yang,et al.  Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke , 2019, Journal of Translational Medicine.

[8]  T. Efferth,et al.  Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[9]  Jian Lv,et al.  Neutrophils and neutrophil-lymphocyte ratio: Inflammatory markers associated with intimal-media thickness of atherosclerosis. , 2018, Thrombosis research.

[10]  Masahiko Watanabe,et al.  Circuit dissection of the role of somatostatin in itch and pain , 2018, Nature Neuroscience.

[11]  M. Woo,et al.  JAK/STAT – Emerging Players in Metabolism , 2018, Trends in Endocrinology & Metabolism.

[12]  J. Chenot,et al.  Non-Specific Low Back Pain. , 2017, Deutsches Arzteblatt international.

[13]  W. Yuan,et al.  Interleukin-17 upregulates vascular endothelial growth factor by activating the JAK/STAT pathway in nucleus pulposus cells. , 2017, Joint, bone, spine : revue du rhumatisme.

[14]  Bin Chen,et al.  IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-α Through the JAK-STAT Signaling Pathway , 2017, Inflammation.

[15]  Zhiyong Li,et al.  The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition , 2017, Scientific Reports.

[16]  Y. Korchev,et al.  Nociceptin/orphanin FQ receptor expression in clinical pain disorders and functional effects in cultured neurons , 2016, Pain.

[17]  Zhi-jun Zhang,et al.  Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice , 2016, Journal of Neuroinflammation.

[18]  Zhi-jun Zhang,et al.  CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. , 2016, The Journal of clinical investigation.

[19]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[20]  Frank Emmert-Streib,et al.  Computational cancer biology: education is a natural key to many locks , 2015, BMC Cancer.

[21]  Massimo Gadina,et al.  The JAK-STAT pathway: impact on human disease and therapeutic intervention. , 2015, Annual review of medicine.

[22]  K. Standifer,et al.  Nociceptin/orphanin FQ peptide receptor antagonist JTC‐801 reverses pain and anxiety symptoms in a rat model of post‐traumatic stress disorder , 2015, British journal of pharmacology.

[23]  Davide Heller,et al.  STRING v10: protein–protein interaction networks, integrated over the tree of life , 2014, Nucleic Acids Res..

[24]  K. Schiene,et al.  Pharmacogenomic study of the role of the nociceptin/orphanin FQ receptor and opioid receptors in diabetic hyperalgesia. , 2014, European journal of pharmacology.

[25]  J. Urban,et al.  Intervertebral disc regeneration: do nutrients lead the way? , 2014, Nature Reviews Rheumatology.

[26]  K. Osuka,et al.  Expression of the JAK/STAT3/SOCS3 signaling pathway in herniated lumbar discs , 2014, Neuroscience Letters.

[27]  J. Pintar,et al.  The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. , 2014, Pharmacology & therapeutics.

[28]  Á. Meana,et al.  The chemokine CCL5 induces CCR1-mediated hyperalgesia in mice inoculated with NCTC 2472 tumoral cells , 2014, Neuroscience.

[29]  D. Sakai,et al.  CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture. , 2014, European cells & materials.

[30]  Gail Haddock,et al.  The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc , 2013, Arthritis Research & Therapy.

[31]  Justin Guinney,et al.  Impact of Bioinformatic Procedures in the Development and Translation of High-Throughput Molecular Classifiers in Oncology , 2013, Clinical Cancer Research.

[32]  B. Bradley,et al.  Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD , 2013, Science Translational Medicine.

[33]  T. Albert,et al.  Expression and Relationship of Proinflammatory Chemokine RANTES/CCL5 and Cytokine IL-1&bgr; in Painful Human Intervertebral Discs , 2013, Spine.

[34]  K. Lutfy,et al.  The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice. , 2013, European journal of pharmacology.

[35]  S. Crystal,et al.  Agreement Between Electronic Medical Record-based and Self-administered Pain Numeric Rating Scale: Clinical and Research Implications , 2013, Medical care.

[36]  Y. Day,et al.  Absence of C–C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model , 2012, PAIN.

[37]  Christine Cedraschi,et al.  Non-specific low back pain , 2012, The Lancet.

[38]  Martin Underwood,et al.  Non-specific low back pain , 2012, The Lancet.

[39]  H. Wilke,et al.  Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[40]  T. Eisenstein,et al.  The effect of gp120 on morphine’s antinociceptive and neurophysiological actions , 2011, Brain, Behavior, and Immunity.

[41]  L. Setton,et al.  Interleukin‐17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule‐1 (ICAM‐1) expression in human intervertebral disc cells , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[42]  Trey Ideker,et al.  Cytoscape 2.8: new features for data integration and network visualization , 2010, Bioinform..

[43]  N. Gretz,et al.  The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. , 2010, The Journal of clinical investigation.

[44]  C. Trautwein,et al.  Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. , 2010, The Journal of clinical investigation.

[45]  J. Woods,et al.  Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys , 2009, Neuropsychopharmacology.

[46]  Jaro Karppinen,et al.  Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals , 2009, Spine.

[47]  I. Shapiro,et al.  Activation of TonEBP by Calcium Controls β1,3-Glucuronosyltransferase-I Expression, a Key Regulator of Glycosaminoglycan Synthesis in Cells of the Intervertebral Disc* , 2009, Journal of Biological Chemistry.

[48]  Marit Holden,et al.  GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies , 2008, Bioinform..

[49]  T. Miyazaki,et al.  Physical limitations to tissue engineering of intervertebral disc cells: effect of extracellular osmotic change on glycosaminoglycan production and cell metabolism. Laboratory investigation. , 2007, Journal of neurosurgery. Spine.

[50]  L. Claes,et al.  Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[51]  Brad T. Sherman,et al.  The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists , 2007, Genome Biology.

[52]  A. Freemont,et al.  Matrix synthesis and degradation in human intervertebral disc degeneration. , 2007, Biochemical Society transactions.

[53]  D. Haschtmann,et al.  Influence of diurnal hyperosmotic loading on the metabolism and matrix gene expression of a whole‐organ intervertebral disc model , 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[54]  T. Albert,et al.  TonEBP/OREBP Is a Regulator of Nucleus Pulposus Cell Function and Survival in the Intervertebral Disc* , 2006, Journal of Biological Chemistry.

[55]  C. Sommer,et al.  Nociceptin and its receptor in rat dorsal root ganglion neurons in neuropathic and inflammatory pain models: implications on pain processing , 2006, Journal of the peripheral nervous system : JPNS.

[56]  G. Calo’,et al.  Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences , 2006, Pain.

[57]  L. Setton,et al.  Osmolarity Regulates Gene Expression in Intervertebral Disc Cells Determined by Gene Array and Real-Time Quantitative RT-PCR , 2005, Annals of Biomedical Engineering.

[58]  S. Roberts,et al.  Human Intervertebral Disc Aggrecan Inhibits Endothelial Cell Adhesion and Cell Migration In Vitro , 2005, Spine.

[59]  P. Roughley.  Biology of Intervertebral Disc Aging and Degeneration: Involvement of the Extracellular Matrix , 2004, Spine.

[60]  R. Coggeshall,et al.  A role for peripheral somatostatin receptors in counter-irritation-induced analgesia , 2003, Neuroscience.

[61]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[62]  Gary D. Bader,et al.  An automated method for finding molecular complexes in large protein interaction networks , 2003, BMC Bioinformatics.

[63]  E. Ongini,et al.  Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury. , 2002, European journal of pharmacology.

[64]  S. Salvadori,et al.  [Nphe1,Arg14,Lys15]Nociceptin‐NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor , 2002, British journal of pharmacology.

[65]  A. Freemont,et al.  Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs , 2002, Molecular pathology : MP.

[66]  R J Miller,et al.  Chemokines and Glycoprotein120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons , 2001, The Journal of Neuroscience.

[67]  R. Coggeshall,et al.  Tonic Control of Peripheral Cutaneous Nociceptors by Somatostatin Receptors , 2001, The Journal of Neuroscience.

[68]  R. Coggeshall,et al.  Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors , 2001, Pain.

[69]  Amanda C.C. Williams,et al.  Simple pain rating scales hide complex idiosyncratic meanings , 2000, Pain.

[70]  E Viikari-Juntura,et al.  Low back pain in relation to lumbar disc degeneration. , 2000, Spine.

[71]  M. Pawlak,et al.  Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of rat knee joint afferents , 1999, Neuroscience Letters.

[72]  S. K. Woo,et al.  Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity. , 1998, American journal of physiology. Renal physiology.

[73]  M. Baggiolini,et al.  B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5 , 1998, The Journal of experimental medicine.

[74]  M. Pawlak,et al.  Inhibitory effect of somatostatin on the mechanosensitivity of articular afferents in normal and inflamed knee joints of the rat , 1997, Pain.

[75]  G. Henderson,et al.  The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ. , 1997, Trends in pharmacological sciences.

[76]  S. Roberts,et al.  Proteoglycan synthesis in the intervertebral disk nucleus: the role of extracellular osmolality. , 1997, The American journal of physiology.

[77]  M. Aebi,et al.  The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. , 1996, The Journal of clinical investigation.

[78]  G Vassart,et al.  ORL1, a novel member of the opioid receptor family , 1994, FEBS letters.

[79]  T. Oegema,et al.  Biochemistry of the intervertebral disc. , 1993, Clinics in sports medicine.

[80]  A. Dickenson,et al.  The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord , 1992, Neuropeptides.

[81]  T. Schall,et al.  A human T cell-specific molecule is a member of a new gene family. , 1988, Journal of immunology.

[82]  Manas Ranjan Gartia,et al.  DNA microarray analysis using a smartphone to detect the BRCA-1 gene. , 2018, The Analyst.

[83]  H. Ding,et al.  Central N/OFQ-NOP Receptor System in Pain Modulation. , 2016, Advances in pharmacology.

[84]  I. Shapiro,et al.  Role of cytokines in intervertebral disc degeneration: pain and disc content , 2014, Nature Reviews Rheumatology.

[85]  竹野 建一.  Physical limitations to tissue engineering of intervertebral disc cells : effect of extracellular osmotic change on glycosaminoglycan production and cell metabolism , 2007 .