The regulation of DNA repair during development

DNA repair is important in such phenomena as carcinogenesis and aging. While much is known about DNA repair in single‐cell systems such as bacteria, yeast, and cultured mammalian cells, it is necessary to examine DNA repair in a developmental context in order to completely understand its processes in complex metazoa such as man. We present data to support the notion that proliferating cells from organ systems, tumors, and embryos have a greater DNA repair capacity than terminally differentiated, nonproliferating cells. Differential expression of repair genes and accessibility of chromatin to repair enzymes are considered as determinants in the developmental regulation of DNA repair.

[1]  D. Mitchell,et al.  Repair of pyrimidine(6-4)pyrimidone photoproducts in mouse skin. , 1990, The Journal of investigative dermatology.

[2]  B. Cool,et al.  Immunocytochemical localization of the base excision repair enzyme uracil DNA glycosylase in quiescent and proliferating normal human cells. , 1989, Cancer research.

[3]  D. Mitchell,et al.  Excision repair of UV radiation-induced DNA damage in Caenorhabditis elegans. , 1989, Genetics.

[4]  D. Mitchell,et al.  THE BIOLOGY OF THE (6–4) PHOTOPRODUCT , 1989, Photochemistry and photobiology.

[5]  P. Tofilon,et al.  Influence of cellular differentiation on repair of ultraviolet-induced DNA damage in murine proadipocytes. , 1988, Radiation research.

[6]  M. Dolan,et al.  Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells. , 1988, Carcinogenesis.

[7]  C. Kenyon,et al.  The nematode Caenorhabditis elegans. , 1988, Science.

[8]  E. Mullaart,et al.  Differences in pyrimidine dimer removal between rat skin cells in vitro and in vivo. , 1988, The Journal of investigative dermatology.

[9]  G. Klein,et al.  Overall changes in chromatin sensitivity to DNase I during differentiation. , 1987, Experimental cell research.

[10]  T. Kuroki,et al.  UV-induced unscheduled DNA synthesis in cultured human epidermal and dermal cells. , 1985, Japanese journal of cancer research : Gann.

[11]  C. Wild,et al.  Modulation of repair of O6-methylguanine in parenchymal and nonparenchymal liver cells of rats treated with dimethylnitrosamine. , 1985, Cancer research.

[12]  D. Murray,et al.  The efficiency of DNA strand-break repair in two fibrosarcoma tumors and in normal tissues of mice irradiated in vivo with X rays. , 1984, Radiation research.

[13]  S. Linn,et al.  DNA repair in cultured mouse cells of increasing population doubling level. , 1984, Mutation research.

[14]  P. Hanawalt,et al.  DNA repair in cultured keratinocytes. , 1983, The Journal of investigative dermatology.

[15]  B. S. Baker,et al.  A gene controlling condensation of heterochromatin in Drosophila melanogaster. , 1983, Science.

[16]  J. Swenberg,et al.  Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[17]  P. Hanawalt,et al.  DNA repair responses in human skin cells. , 1981, The Journal of investigative dermatology.

[18]  M. S. Fisher,et al.  Photoreactivation of ultraviolet radiation-induced pyrimidine dimers in neonatal BALB/c mouse skin. , 1981, Cancer research.

[19]  R. Setlow,et al.  Repair of ultraviolet light damage to the DNA of cultured human epidermal keratinocytes and fibroblasts. , 1979, The Journal of investigative dermatology.

[20]  D. Grube,et al.  ABSENCE OF PHOTOREACTIVATION OF PYRIMIDINE DIMERS IN THE EPIDERMIS OF HAIRLESS MICE FOLLOWING EXPOSURES TO ULTRAVIOLET LIGHT * , 1978, Photochemistry and photobiology.

[21]  E. Raz,et al.  Changing capacity for DNA excision repair in mouse embryonic cells in vitro. , 1977, Experimental cell research.

[22]  M. Bender,et al.  Uniformity of Radiation-induced Mutation Rates among Different Species , 1973, Nature.

[23]  W. Reed,et al.  Defect in DNA Synthesis in Skin of Patients with Xeroderma Pigmentosum Demonstrated in vivo , 1970, Science.

[24]  J. Cleaver.  Defective Repair Replication of DNA in Xeroderma Pigmentosum , 1968, Nature.

[25]  W. Siede.  The RAD6 gene of yeast: A link between DNA repair, chromosome structure and protein degradation? , 1988, Radiation and environmental biophysics.

[26]  D. Murray,et al.  Differential repair of gamma-ray-induced DNA strand breaks by various cellular subpopulations of mouse jejunal epithelium and bone marrow in vivo. , 1987, Radiation research.

[27]  V. Bohr.  Preferential DNA repair in active genes. , 1987, Danish medical bulletin.

[28]  H. Krokan,et al.  U.v.-induced DNA damage and its repair in human skin in vivo studied by sensitive immunohistochemical methods. , 1983, Carcinogenesis.