Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene

[1]  R.,et al.  The relationship between body mass and age at diagnosis of type 1 diabetes , 2003 .

[2]  T. Wilkin,et al.  Increasing body weight predicts the earlier onset of insulin‐dependant diabetes in childhood: testing the ‘accelerator hypothesis’ (2) , 2005, Diabetic medicine : a journal of the British Diabetic Association.

[3]  D. Gasser,et al.  Genetic control of the immune response in mice. IV. Relationship between graft vs host reactivity and possession of the high tumor genotypes A y a and A vy a. , 1973, Journal of immunology.

[4]  Bhagirath Singh,et al.  The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. , 1997, Immunity.

[5]  A. Butler The melanocortin system and energy balance , 2006, Peptides.

[6]  T. Wilkin The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes , 2001, Diabetologia.

[7]  Sanjiv Sam Gambhir,et al.  Bioluminescent monitoring of islet graft survival after transplantation. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[8]  M. V. von Herrath,et al.  Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. , 2009, The Journal of clinical investigation.

[9]  R. Cone,et al.  Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.

[10]  H. Pircher,et al.  Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha. , 1993, Journal of immunology.

[11]  R. Sun,et al.  Function of Rta Is Essential for Lytic Replication of Murine Gammaherpesvirus 68 , 2001, Journal of Virology.

[12]  G. Wolff Obesity as a pleiotropic effect of gene action. , 1997, The Journal of nutrition.

[13]  K. Vehik,et al.  Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study , 2016, Diabetes.

[14]  G. Bell,et al.  Transgenic mice with green fluorescent protein-labeled pancreatic β-cells , 2003 .

[15]  J. Todd,et al.  Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study , 2017, PLoS medicine.

[16]  B. Metcalf,et al.  Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes. , 2003, Diabetes care.

[17]  E. Bonifacio,et al.  Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes? , 2009, Diabetologia.

[18]  T. Wilkin Major increase in Type 1 diabetes: no support for the Accelerator Hypothesis , 2008, Diabetic medicine : a journal of the British Diabetic Association.

[19]  S. Virtanen,et al.  Infant feeding patterns during the first year of life in offspring of mothers with and without type 1 diabetes: results from the TEDDY (The Environmental Determinants of Diabetes in the Young) Study , 2008 .

[20]  M. Redondo,et al.  Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development? , 2017, Diabetes Care.

[21]  T. Wilkin The convergence of type 1 and type 2 diabetes in childhood , 2012, Pediatric diabetes.

[22]  P. Burn,et al.  Melanocortin-4 receptor: A novel signalling pathway involved in body weight regulation , 1999, International Journal of Obesity.

[23]  L. Groop,et al.  Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study , 2018, Diabetologia.

[24]  J. Geisler,et al.  Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. V. von Herrath,et al.  How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. , 1994, Immunity.

[26]  R. Sun,et al.  Persistent Gammaherpesvirus Replication and Dynamic Interaction with the Host In Vivo , 2008, Journal of Virology.

[27]  R. Hamman,et al.  Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. , 2006, Diabetes care.

[28]  S. Gambhir,et al.  Multimodality Imaging of β-Cells in Mouse Models of Type 1 and 2 Diabetes , 2011, Diabetes.

[29]  L. Makowski,et al.  The inflammation highway: metabolism accelerates inflammatory traffic in obesity , 2012, Immunological reviews.

[30]  S. Larsson with at a Mendelian randomization study. , 2020 .

[31]  David M Maahs,et al.  Epidemiology of type 1 diabetes. , 2010, Endocrinology and metabolism clinics of North America.

[32]  P. Lehmann,et al.  Shifting T‐cell activation thresholds in autoimmunity and determinant spreading , 1998, Immunological reviews.

[33]  M. O’Connell,et al.  Major increase in Type 1 diabetes—no support for the Accelerator Hypothesis , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[34]  M. Atkinson,et al.  Type 1 diabetes , 2014, The Lancet.

[35]  F. T. E. Group,et al.  The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants , 2016, Diabetologia.

[36]  M. Herrath Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus. , 2002 .

[37]  A. Cooke,et al.  Murine Gammaherpesvirus-68 Infection Alters Self-Antigen Presentation and Type 1 Diabetes Onset in NOD Mice1 , 2007, The Journal of Immunology.

[38]  Jide Tian,et al.  Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens , 2009, Diabetes.

[39]  D. Gasser,et al.  Genetic control of the immune response in mice. IV. Relationship between graft vs host reactivity and possession of the high tumor genotypes A y a and A vy a. , 1973, Journal of immunology.

[40]  T. Reinehr,et al.  The ‘accelerator hypothesis’: relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus , 2005, Diabetologia.

[41]  M. Wauben,et al.  Identification of the immunodominant CTL epitope of EGFP in C57BL/6 mice , 2008, Gene Therapy.

[42]  A. Tobin,et al.  Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice , 1996, Nature Medicine.

[43]  Blake Middleton,et al.  Infectious Th1 and Th2 autoimmunity in diabetes‐prone mice , 1998, Immunological reviews.

[44]  G. Barsh,et al.  Obesity, diabetes, and neoplasia in yellow Avy/‐ mice: ectopic expression of the agouti gene , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  R. Sun,et al.  Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection , 2004, Journal of Virology.

[46]  M. V. von Herrath Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus. , 2002, Current topics in microbiology and immunology.

[47]  Victor J. Hruby,et al.  Role of melanocortinergic neurons in feeding and the agouti obesity syndrome , 1997, Nature.

[48]  G. Bell,et al.  Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. , 2003, American journal of physiology. Endocrinology and metabolism.

[49]  G. Wolff Body Composition and Coat Color Correlation in Different Phenotypes of "Viable Yellow" Mice , 1965, Science.

[50]  P. Ohashi,et al.  Immunological perspective of self versus tumor antigens: insights from the RIP‐gp model , 2011, Immunological reviews.

[51]  G. Wolff,et al.  Pancreatic Islet Cells in Preobese Yellow Avy/- Mice: Relation to Adult Hyperinsulinemia and Obesity , 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.