Immune interferon in the circulation of patients with autoimmune disease.

The observation that type II, or immune, interferon could be produced by peripheral-blood leukocytes in vitro on an immune-specific basis suggested that it also might be produced in vivo in various autoimmune disorders. We found immune interferon in the serums of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma and Sjögren's syndrome. Among 28 patients with systemic lupus erythematosus, 71 per cent of those with active and 21 per cent of those with inactive disease showed interferon in their serums. Serial serum samples showed a good correlation between interferon titers and disease activity. Moreover, interferon titers correlated positively with antibodies to DNA and negatively with serum levels of the third component of complement. It is possible that the production of interferon may contribute to immunologic aberrations in auto-immune diseases and also protect the already compromised host from viral infections.

[1]  H. Moutsopoulos,et al.  Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis. , 1979, The American journal of medicine.

[2]  B. Haynes,et al.  Immunoregulatory aberrations in systemic lupus erythematosus. , 1978, Journal of immunology.

[3]  T. Merigan,et al.  Time and dosage dependence of immunoenhancement by murine type II interferon preparations. , 1978, Cellular immunology.

[4]  A. Steinberg,et al.  Herpes zoster in patients with systemic lupus erythematosus. , 1978, Arthritis and rheumatism.

[5]  A. Billiau,et al.  Interferon treatment of NZB mice: accelerated progression of autoimmune disease , 1978, Infection and immunity.

[6]  G. Granger,et al.  Detection of lymphotoxins in vivo. I. Specific identification of short-lived LT activity in the plasma of various human patients employing rabbit anti-human LT sera in vitro. , 1978, Clinical immunology and immunopathology.

[7]  O. Strannegard,et al.  Modulation of immune responses in newborn and adult mice by interferon , 1978, Infection and immunity.

[8]  G. Trinchieri,et al.  Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis , 1978, The Journal of experimental medicine.

[9]  I. Gresser.  On the varied biologic effects of interferon. , 1977, Cellular immunology.

[10]  S. Baron,et al.  Vesicular stomatitis virus plaque production in monolayer cultures with liquid overlay medium: description and adaptation to a one-day, human interferon-plaque , 1976, Journal of clinical microbiology.

[11]  I. Gresser,et al.  Progressive glomerulonephritis in mice treated with interferon preparations at birth , 1976, Nature.

[12]  J. Hayslett,et al.  PROGNOSTIC INDICES IN LUPUS NEPHRITIS , 1976, Medicine.

[13]  Skurkovich Sv,et al.  The probable role of interferon in allergy. , 1975 .

[14]  A. Notkins,et al.  Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes. , 1975, Journal of immunology.

[15]  T. Merigan,et al.  Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons. , 1975, Journal of immunology.

[16]  P. Stastny,et al.  Lymphokines in the rheumatoid joint. , 1975, Arthritis and rheumatism.

[17]  W. Seaman,et al.  Systemic lupus erythematosus. Contrasts and comparisons. , 1975, Annals of internal medicine.

[18]  T. Merigan,et al.  Administration of human leukocyte interferon in herpes zoster. I. Safety, circulating, antiviral activity, and host responses to infection. , 1974, The Journal of infectious diseases.

[19]  J. Youngner,et al.  Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. , 1973, Journal of immunology.