Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts

[1]  S. Alam,et al.  COX‐2/EP2‐EP4/&bgr;‐catenin signaling regulates patulin‐induced intestinal cell proliferation and inflammation , 2018, Toxicology and applied pharmacology.

[2]  Xue-Dong Li,et al.  Connexin 43 Modulates Osteogenic Differentiation of Bone Marrow Stromal Cells Through GSK-3beta/Beta-Catenin Signaling Pathways , 2018, Cellular Physiology and Biochemistry.

[3]  C. Ward,et al.  Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes , 2017, Science Signaling.

[4]  R. Civitelli,et al.  Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling , 2017, PloS one.

[5]  Atum M. Buo,et al.  Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  M. Ivan,et al.  Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging , 2017, Aging cell.

[7]  M. Subramaniam,et al.  TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone , 2017, Nucleic acids research.

[8]  J. Stains,et al.  Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling , 2017, Current Osteoporosis Reports.

[9]  R. Tomlinson,et al.  Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation , 2017, Journal of Cell Science.

[10]  H. Donahue,et al.  Joint diseases: from connexins to gap junctions , 2017, Nature Reviews Rheumatology.

[11]  C. Fan,et al.  Inhibition of connexin 43 prevents trauma-induced heterotopic ossification , 2016, Scientific Reports.

[12]  S. Hayano,et al.  Alternation in the gap-junctional intercellular communication capacity during the maturation of osteocytes in the embryonic chick calvaria. , 2016, Bone.

[13]  Atum M. Buo,et al.  A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells , 2016, Bone Research.

[14]  L. Bonewald,et al.  The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth. , 2016, The international journal of biochemistry & cell biology.

[15]  Aditi Gupta,et al.  Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression. , 2016, Cellular signalling.

[16]  A. Robling,et al.  Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation. , 2016, Bone.

[17]  J. Amédée,et al.  Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone , 2016, BMC Cell Biology.

[18]  N. Udagawa,et al.  Regulation of bone metabolism by Wnt signals. , 2016, Journal of biochemistry.

[19]  J. Stains,et al.  Connexins in the skeleton. , 2016, Seminars in cell & developmental biology.

[20]  Hai Zhang,et al.  Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor. , 2015, Oncology reports.

[21]  M. Saunders,et al.  Impact of Gap Junctional Intercellular Communication on MLO-Y4 Sclerostin and Soluble Factor Expression , 2015, Annals of Biomedical Engineering.

[22]  Mark L. Johnson,et al.  In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism. , 2015, Bone.

[23]  Aditi Gupta,et al.  Connexin43 enhances the expression of osteoarthritis-associated genes in synovial fibroblasts in culture , 2014, BMC Musculoskeletal Disorders.

[24]  Mark L. Johnson,et al.  Deletion of a Single β‐Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[25]  Jean X. Jiang,et al.  Direct Regulation of Osteocytic Connexin 43 Hemichannels through AKT Kinase Activated by Mechanical Stimulation* , 2014, The Journal of Biological Chemistry.

[26]  H. Donahue,et al.  Shifting Paradigms on the Role of Connexin43 in the Skeletal Response to Mechanical Load , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[27]  Jean X. Jiang,et al.  14-3-3&thgr; facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels , 2014, Journal of Cell Science.

[28]  Wei Chen,et al.  Wnt and the Wnt signaling pathway in bone development and disease. , 2014, Frontiers in bioscience.

[29]  Shengnan Li,et al.  Connexin 43 is a potential regulator in fluid shear stress‐induced signal transduction in osteocytes , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[30]  G. Lewis,et al.  Inhibition of GSK-3β Rescues the Impairments in Bone Formation and Mechanical Properties Associated with Fracture Healing in Osteoblast Selective Connexin 43 Deficient Mice , 2013, PloS one.

[31]  J. Aubin,et al.  The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption‐stimulating bone matrix and abrogation of old‐age–related bone loss , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  J. Stains,et al.  An intact connexin43 is required to enhance signaling and gene expression in osteoblast‐like cells , 2013, Journal of cellular biochemistry.

[33]  M. Passos-Bueno,et al.  A Novel Autosomal Recessive GJA1 Missense Mutation Linked to Craniometaphyseal Dysplasia , 2013, PloS one.

[34]  A. Robling,et al.  Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[35]  J. Stains,et al.  Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43 , 2013, Calcified Tissue International.

[36]  M. Amling,et al.  Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin , 2013, The Journal of cell biology.

[37]  L. Plotkin,et al.  Beyond gap junctions: Connexin43 and bone cell signaling. , 2013, Bone.

[38]  Susan K. Grimston,et al.  Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice , 2012, PloS one.

[39]  Gregory F Weber,et al.  Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels , 2012, Proceedings of the National Academy of Sciences.

[40]  G. Passeri,et al.  Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  L. Plotkin,et al.  Connexin43 interacts with βarrestin: A pre‐requisite for osteoblast survival induced by parathyroid hormone , 2011, Journal of cellular biochemistry.

[42]  B. Guillotin,et al.  Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling , 2011, Molecular biology of the cell.

[43]  Gabriela G. Loots,et al.  Prostaglandin E2 Signals Through PTGER2 to Regulate Sclerostin Expression , 2011, PloS one.

[44]  Lynda F. Bonewald,et al.  Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis , 2010, Molecular and Cellular Biology.

[45]  R. Weinstein,et al.  Connexin 43 Is Required for the Anti‐Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[46]  T. Lamano,et al.  Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry. , 2008, Journal of oral science.

[47]  Mark L. Johnson,et al.  Osteocytes, mechanosensing and Wnt signaling. , 2008, Bone.

[48]  Gordon B. Mills,et al.  Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity* , 2007, Journal of Biological Chemistry.

[49]  Leroy Hood,et al.  PTEN-deficient intestinal stem cells initiate intestinal polyposis , 2007, Nature Genetics.

[50]  K. Willecke,et al.  Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43 , 2006, Journal of Cell Science.

[51]  S. Doty.  Morphological evidence of gap junctions between bone cells , 2006, Calcified Tissue International.

[52]  K. Druey,et al.  Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis , 2005, Science.

[53]  L. Bonewald,et al.  Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. , 2005, Molecular biology of the cell.

[54]  Bart O. Williams,et al.  Essential Role of β-Catenin in Postnatal Bone Acquisition* , 2005, Journal of Biological Chemistry.

[55]  Hans Clevers,et al.  Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. , 2005, Developmental cell.

[56]  J. Stains,et al.  Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription. , 2004, Molecular biology of the cell.

[57]  M. Bouxsein,et al.  Essential role of beta-catenin in postnatal bone acquisition. , 2005, The Journal of biological chemistry.

[58]  R. Nusse,et al.  The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.

[59]  F. Lecanda,et al.  Gap Junctional Communication Modulates Gene Transcription by Altering the Recruitment of Sp1 and Sp3 to Connexin-response Elements in Osteoblast Promoters* , 2003, Journal of Biological Chemistry.

[60]  C. Jacobs,et al.  Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. , 2003, Bone.

[61]  Bernd Wollnik,et al.  Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. , 2003, American journal of human genetics.

[62]  Zijie Sun,et al.  Phosphatidylinositol 3-Kinase/Akt Stimulates Androgen Pathway through GSK3β Inhibition and Nuclear β-Catenin Accumulation* , 2002, The Journal of Biological Chemistry.

[63]  S. Manolagas,et al.  Transduction of Cell Survival Signals by Connexin-43 Hemichannels* , 2002, The Journal of Biological Chemistry.

[64]  Zijie Sun,et al.  Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation. , 2002, The Journal of biological chemistry.

[65]  T. Steinberg,et al.  Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction , 2000, The Journal of cell biology.

[66]  C. Jacobs,et al.  Functional Gap Junctions Between Osteocytic and Osteoblastic Cells , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[67]  T. Steinberg,et al.  Gap junctional communication modulates gene expression in osteoblastic cells. , 1998, Molecular biology of the cell.

[68]  J. Chow,et al.  Role of Nitric Oxide and Prostaglandins in Mechanically Induced Bone Formation , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[69]  M. Forwood,et al.  Inducible cyclo‐oxygenase (COX‐2) mediates the induction of bone formation by mechanical loading in vivo , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[70]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[71]  T. Steinberg,et al.  Connexin43 mediates direct intercellular communication in human osteoblastic cell networks. , 1993, The Journal of clinical investigation.

[72]  E. Hertzberg,et al.  Gap junctional communication. , 1981, Annual review of physiology.