Application of the nuclear overhauser effect difference experiment: Assignment of the configuration of carboprostacyclin

Nuclear Overhauser effect difference experiments, together with difference decoupling and inversion recovery measurements, have allowed the complete assignment of the proton magnetic resonance spectrum of carboprostacyclin. The nuclear Overhauser effect measurements prove the 5E configuration at C-5 for carboprostacyclin. Protons H-2,2*, H-3,3*, and H-4,4* are observed to be nonequivalent due to the asymmetric nature of this molecule.

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