Obesity and health-related quality of life: results from a weight loss trial.

AIMS To measure health-related quality of life (HRQoL) in overweight and obese New Zealand adults taking part in a weight loss trial, and to compare findings with the New Zealand population. METHODS Individuals (aged over 18 years with a BMI of 28-50 kg/m2) participated in a randomised controlled weight loss trial. HRQoL was measured using the SF-36 questionnaire. RESULTS The 250 study participants had a mean (SD) age of 48 (12) years and a mean BMI of 35.4 (5.3) kg/m2. Mean physical component (PCS) and mental component summary scores (MCS) were 47.2 (9.0) and 46.9 (11.1) respectively. Participants in the highest BMI tertile (>37 kg/m2) reported significantly lower PCS scores compared with those in the middle and lowest tertiles (p=0.01), but no significant differences were seen in MCS scores (p=0.65). Comparison with population norms revealed significantly lower mean scores in all 8 SF-36 domains except mental health. No significant effect of modest weight loss on HRQoL was seen. CONCLUSIONS These overweight and obese New Zealand adults experienced significantly impaired HRQoL compared to the New Zealand population. Small reductions in weight had no significant impact on HRQoL in this substantially overweight population.

[1]  Michael J Thun,et al.  Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. , 2003, The New England journal of medicine.

[2]  G A Colditz,et al.  Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men , 1994, Diabetes Care.

[3]  A. Rodgers,et al.  The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults , 2004, International Journal of Obesity.

[4]  John E. Ware,et al.  SF-36 physical and mental health summary scales : a user's manual , 1994 .

[5]  Majid Ezzati,et al.  For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group , 2022 .

[6]  R. Fitzpatrick,et al.  Quality of life measurement: bibliographic study of patient assessed health outcome measures , 2002, BMJ : British Medical Journal.

[7]  H. Adami,et al.  Overweight as an avoidable cause of cancer in Europe , 2001, International journal of cancer.

[8]  K. Brownell,et al.  Bias, discrimination, and obesity. , 2001, Obesity research.

[9]  G. Hartley,et al.  The relationship between health-related quality of life and weight loss. , 2001, Obesity research.

[10]  J. Karlsson Health-related quality of life in obesity , 2003 .

[11]  C. Shapiro,et al.  Psychological manifestations of obesity. , 2003, Journal of psychosomatic research.

[12]  M. Sprangers,et al.  Which chronic conditions are associated with better or poorer quality of life? , 2000, Journal of clinical epidemiology.

[13]  D. Allison,et al.  Obesity and quality of life: mediating effects of pain and comorbidities. , 2003, Obesity research.

[14]  William W Eaton,et al.  Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. , 2003, American journal of epidemiology.

[15]  S. Haslett,et al.  SF‐36 health survey reliability, validity and norms for New Zealand , 1999, Australian and New Zealand journal of public health.

[16]  U. Evers Larsson Influence of weight loss on pain, perceived disability and observed functional limitations in obese women , 2004 .

[17]  B. Wilson,et al.  Obesity and body fat distribution in the New Zealand population. , 2001, The New Zealand medical journal.

[18]  D. Simonson,et al.  Assessment of quality-of-life outcomes. , 1996, The New England journal of medicine.

[19]  K. Flegal,et al.  Prevalence and trends in obesity among US adults, 1999-2000. , 2002, JAMA.

[20]  Cliona Ni Mhurchu,et al.  Coronary heart disease and body mass index: a systematic review of the evidence from larger prospective cohort studies. , 2002, Seminars in vascular medicine.

[21]  J. Manson,et al.  Weight, weight change, and coronary heart disease in women. Risk within the 'normal' weight range. , 1995, JAMA.

[22]  D Spiegelman,et al.  Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. , 1995, American journal of epidemiology.

[23]  Ronette L. Kolotkin,et al.  Quality of life and obesity , 2001, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[24]  K. Fontaine,et al.  Impact of weight loss on Health-Related Quality of Life , 1999, Quality of Life Research.

[25]  H. Doll,et al.  Obesity and physical and emotional well-being: associations between body mass index, chronic illness, and the physical and mental components of the SF-36 questionnaire. , 2000, Obesity research.

[26]  G A Colditz,et al.  Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study. , 1997, American journal of epidemiology.

[27]  A. Rissanen,et al.  Health-related quality of life in a randomised placebo-controlled trial of sibutramine in obese patients with type II diabetes , 2004, International Journal of Obesity.

[28]  I. Sartori Weight, Weight Change, and Coronary Heart Disease in Women: Risk Within the 'Normal' Weight Range , 1996 .

[29]  K. Fontaine,et al.  Obesity and health‐related quality of life , 2001, Obesity reviews : an official journal of the International Association for the Study of Obesity.