α-synuclein in the pathophysiology of Alzheimer’s disease
暂无分享,去创建一个
[1] C. Tanner,et al. Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. , 2019, Neurology.
[2] A. Fagan,et al. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease , 2018, Acta Neuropathologica Communications.
[3] Richard J. Caselli,et al. Age stratification corrects bias in estimated hazard of APOE genotype for Alzheimer's disease , 2018, Alzheimer's & dementia.
[4] O. Isacson,et al. Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age , 2018, Scientific Reports.
[5] Ulf Dettmer. Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease , 2018, Front. Neurosci..
[6] S. Gandhi,et al. Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases , 2018, The FEBS journal.
[7] J. Trojanowski,et al. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease , 2018, Alzheimer's & Dementia.
[8] O. Sporns,et al. Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers , 2018, Alzheimer's & Dementia.
[9] G. Bloom,et al. Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons , 2018, Acta Neuropathologica.
[10] A. Tandon,et al. Import and Export of Misfolded α-Synuclein , 2018, Front. Neurosci..
[11] W. Klein,et al. The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade , 2018, Journal of Alzheimer's disease : JAD.
[12] J. Schott,et al. Molecular biomarkers of Alzheimer's disease: progress and prospects , 2018, Disease Models & Mechanisms.
[13] C. Jack,et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease , 2018, Alzheimer's & Dementia.
[14] Nick C Fox,et al. Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic , 2018, Alzheimer's Research & Therapy.
[15] R. Riek,et al. Cryo-EM structure of alpha-synuclein fibrils , 2018, bioRxiv.
[16] Alan J. Thomas,et al. Improving the identification of dementia with Lewy bodies in the context of an Alzheimer’s-type dementia , 2018, Alzheimer's Research & Therapy.
[17] Romain F. Laine,et al. C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction , 2018, Nature Communications.
[18] D. Dickson,et al. Multiple system atrophy and apolipoprotein E , 2018, Movement disorders : official journal of the Movement Disorder Society.
[19] V. Lee,et al. Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies , 2018, Neurobiology of Disease.
[20] J. Trojanowski,et al. A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. , 2018, Journal of Alzheimer's disease : JAD.
[21] M. Ingelsson,et al. Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes , 2017, The Journal of Neuroscience.
[22] Daniel R. Schonhaut,et al. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease , 2017, Brain : a journal of neurology.
[23] C. Wattmo,et al. Early- versus late-onset Alzheimer’s disease in clinical practice: cognitive and global outcomes over 3 years , 2017, Alzheimer's Research & Therapy.
[24] C. Jack,et al. Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers , 2017, The Lancet Neurology.
[25] K. Blennow. A Review of Fluid Biomarkers for Alzheimer’s Disease: Moving from CSF to Blood , 2017, Neurology and Therapy.
[26] E. Masliah,et al. Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology , 2017, Acta Neuropathologica Communications.
[27] D. Bennett,et al. Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits , 2017, Proceedings of the National Academy of Sciences.
[28] P. Whitley,et al. Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species. , 2017, Biochemistry.
[29] K. Blennow,et al. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia , 2017, Alzheimer's & Dementia.
[30] Giovanni B. Frisoni,et al. Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment , 2017, Alzheimer's & Dementia.
[31] R. Faull,et al. α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients , 2017, Scientific Reports.
[32] K. Thorn,et al. α-Synuclein Promotes Dilation of the Exocytotic Fusion Pore , 2017, Nature Neuroscience.
[33] A. Nordberg,et al. Tau PET imaging: present and future directions , 2017, Molecular Neurodegeneration.
[34] P. Calabresi,et al. Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease , 2017, Scientific Reports.
[35] J. Olivo-Marin,et al. Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes , 2016, The EMBO journal.
[36] G. Bråthen,et al. Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer’s disease, mild cognitive impairment, or healthy controls: a two year follow-up study , 2016, BMC Neurology.
[37] E. Masliah,et al. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model , 2016, The Journal of Neuroscience.
[38] G. Taglialatela,et al. Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies. , 2016, Current pharmaceutical design.
[39] M. Hasegawa,et al. α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly* , 2016, The Journal of Biological Chemistry.
[40] G. Bu,et al. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan , 2016, Molecular Neurodegeneration.
[41] A. Björklund,et al. Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain , 2016, Proceedings of the National Academy of Sciences.
[42] N. Pervaiz,et al. The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication , 2016, Scientific Reports.
[43] J. Hardy,et al. The amyloid hypothesis of Alzheimer's disease at 25 years , 2016, EMBO molecular medicine.
[44] C. Jack,et al. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria , 2016, Alzheimer's & Dementia.
[45] Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats , 2016, Apoptosis.
[46] J. Trojanowski,et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology , 2016, Acta Neuropathologica.
[47] Jun Wang,et al. Rate of early onset Alzheimer's disease: a systematic review and meta-analysis. , 2015, Annals of translational medicine.
[48] K. Blennow,et al. Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study , 2015, Neurobiology of Aging.
[49] Michel Goedert,et al. Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein , 2015, Science.
[50] D. Selkoe,et al. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity , 2015, Proceedings of the National Academy of Sciences.
[51] Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation , 2015, Nature communications.
[52] M. Carrillo,et al. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective , 2015, Alzheimer's & Dementia.
[53] Karl Herrup,et al. The case for rejecting the amyloid cascade hypothesis , 2015, Nature Neuroscience.
[54] Kui Ye,et al. Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders , 2015, International Psychogeriatrics.
[55] Elisabeth L. Moussaud-Lamodière,et al. Alpha-synuclein and tau: teammates in neurodegeneration? , 2014, Molecular Neurodegeneration.
[56] P. McLean,et al. α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling , 2014, Current Biology.
[57] P. Deyn,et al. Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels , 2014, Alzheimer's & Dementia.
[58] T. Südhof,et al. α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation , 2014, Proceedings of the National Academy of Sciences.
[59] I. McKeith,et al. The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis , 2014, Alzheimer's Research & Therapy.
[60] D. Dickson,et al. Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. , 2014, Brain : a journal of neurology.
[61] K. Blennow,et al. Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease , 2014, Alzheimer's Research & Therapy.
[62] M. Gąssowska,et al. Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells , 2014, PloS one.
[63] T. Golde,et al. Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice , 2014, Acta Neuropathologica.
[64] D. Aarsland,et al. Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort , 2014, Journal of Neurology, Neurosurgery & Psychiatry.
[65] H. Berendse,et al. Reduced α‐synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity , 2014, European journal of neurology.
[66] E. Londos,et al. Low levels of soluble NG2 in cerebrospinal fluid from patients with dementia with Lewy bodies. , 2014, Journal of Alzheimer's disease : JAD.
[67] Michael Ewers,et al. Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies. , 2014, Journal of Alzheimer's disease : JAD.
[68] Nick C Fox,et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.
[69] E. Kapaki,et al. The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease , 2013, PLoS ONE.
[70] B. Boeve,et al. Incidence of dementia with Lewy bodies and Parkinson disease dementia. , 2013, JAMA neurology.
[71] D. Selkoe,et al. Defining the Native State of α-Synuclein , 2013, Neurodegenerative Diseases.
[72] R. Edwards,et al. The Function of α-Synuclein , 2013, Neuron.
[73] Mathias Jucker,et al. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases , 2013, Nature.
[74] F. Brodsky,et al. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds , 2013, Proceedings of the National Academy of Sciences.
[75] D. Eliezer. The mysterious C-terminal tail of alpha-synuclein: nanobody's guess. , 2013, Journal of molecular biology.
[76] J. Trojanowski,et al. CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease , 2013, Acta Neuropathologica.
[77] M. Farrer,et al. Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.
[78] J. Weuve,et al. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census , 2013, Neurology.
[79] Ronald Melki,et al. G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndrome , 2013, Annals of neurology.
[80] Douglas Galasko,et al. Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems , 2013, Alzheimer's Research & Therapy.
[81] C. Jack,et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers , 2013, The Lancet Neurology.
[82] Huaxi Xu,et al. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy , 2013, Nature Reviews Neurology.
[83] Cornelia M. Wilson,et al. Tau protein kinases: Involvement in Alzheimer's disease , 2013, Ageing Research Reviews.
[84] D. Selkoe,et al. In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells* , 2013, The Journal of Biological Chemistry.
[85] Sandra E Black,et al. Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome , 2013, Alzheimer's Research & Therapy.
[86] L. Minthon,et al. Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy , 2013, PloS one.
[87] Mark E. Schmidt,et al. The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception , 2012, Alzheimer's & Dementia.
[88] Min Shi,et al. α-Synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment. , 2013, Journal of Alzheimer's disease : JAD.
[89] E. Masliah,et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.
[90] Adam J. Trexler,et al. Function and Dysfunction of α-Synuclein: Probing Conformational Changes and Aggregation by Single Molecule Fluorescence , 2012, Molecular Neurobiology.
[91] R. Mayeux,et al. Epidemiology of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.
[92] D. Bennett,et al. Soluble α-Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology , 2012, The Journal of Neuroscience.
[93] Subhojit Roy,et al. α-Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis , 2012, The Journal of Neuroscience.
[94] R. Sakakibara,et al. Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease , 2012, Alzheimer disease and associated disorders.
[95] C. Haass,et al. Trafficking and proteolytic processing of APP. , 2012, Cold Spring Harbor perspectives in medicine.
[96] A. Björklund,et al. Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons , 2012, Proceedings of the National Academy of Sciences.
[97] E. Londos,et al. Altered CSF orexin and α-synuclein levels in dementia patients. , 2012, Journal of Alzheimer's disease : JAD.
[98] K. Tamura,et al. Stimulatory effect of α‐synuclein on the tau‐phosphorylation by GSK‐3β , 2011, The FEBS journal.
[99] A. McKee,et al. Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease* , 2011, The Journal of Biological Chemistry.
[100] Wei Wang,et al. A soluble α-synuclein construct forms a dynamic tetramer , 2011, Proceedings of the National Academy of Sciences.
[101] K. Yaffe,et al. The projected effect of risk factor reduction on Alzheimer's disease prevalence , 2011, The Lancet Neurology.
[102] D. Selkoe,et al. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation , 2011, Nature.
[103] Portland Press Ltd. The amyloid cascade hypothesis has misled the pharmaceutical industry. , 2011, Biochemical Society transactions.
[104] E. Waxman,et al. Induction of Intracellular Tau Aggregation Is Promoted by α-Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau , 2011, The Journal of Neuroscience.
[105] J. Morris,et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[106] Denise C. Park,et al. Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[107] D. Hong,et al. The role of the C‐terminus of human α‐synuclein: Intra‐disulfide bonds between the C‐terminus and other regions stabilize non‐fibrillar monomeric isomers , 2011, FEBS letters.
[108] P. Novick,et al. Role of Rab GTPases in membrane traffic and cell physiology. , 2011, Physiological reviews.
[109] O. Lindvall,et al. Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. , 2011, Journal of Parkinson's disease.
[110] Nick C Fox,et al. Revising the definition of Alzheimer's disease: a new lexicon , 2010, The Lancet Neurology.
[111] S. Chandra,et al. αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction , 2010, Proceedings of the National Academy of Sciences.
[112] Jack H Freed,et al. The Lipid-binding Domain of Wild Type and Mutant α-Synuclein , 2010, The Journal of Biological Chemistry.
[113] Masaki Tanaka,et al. Extracellular neurosin degrades α-synuclein in cultured cells , 2010, Neuroscience Research.
[114] E. Masliah,et al. A Pathologic Cascade Leading to Synaptic Dysfunction in α-Synuclein-Induced Neurodegeneration , 2010, The Journal of Neuroscience.
[115] T. Tokuda,et al. Differential levels of α-synuclein, β-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease , 2010, Journal of Neurology, Neurosurgery & Psychiatry.
[116] J. Trojanowski,et al. Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline , 2010, The Journal of Neuroscience.
[117] M. Ntzouni,et al. Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival , 2010, The Journal of Neuroscience.
[118] A. Manning-Boğ,et al. Lysosomal Degradation of α-Synuclein in Vivo* , 2010, The Journal of Biological Chemistry.
[119] Aneeka M Hancock,et al. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. , 2010, Brain : a journal of neurology.
[120] R. Nicoll,et al. Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis , 2010, Neuron.
[121] W. M. van der Flier,et al. CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease. , 2010, Journal of Alzheimer's disease : JAD.
[122] J. Trojanowski,et al. Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells , 2009, Proceedings of the National Academy of Sciences.
[123] L. Stefanis,et al. Functional dissection of the α‐synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219 , 2009, Journal of neurochemistry.
[124] T. Duka,et al. α‐Synuclein contributes to GSK‐3β‐catalyzed Tau phosphorylation in Parkinson's disease models , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[125] Y. Stern,et al. Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study. , 2009, Archives of neurology.
[126] F. Schmitt,et al. Lewy Body Pathology in Normal Elderly Subjects , 2009, Journal of neuropathology and experimental neurology.
[127] Torsten Schwede,et al. Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective , 2009, Electrophoresis.
[128] Marie-Claude Potier,et al. Classification and basic pathology of Alzheimer disease , 2009, Acta Neuropathologica.
[129] E. Lemke,et al. Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence , 2009, Proceedings of the National Academy of Sciences.
[130] Adam J. Trexler,et al. Alpha-synuclein binds large unilamellar vesicles as an extended helix. , 2009, Biochemistry.
[131] K. Blennow,et al. Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss? , 2009, Neuroscience Letters.
[132] R. Melis,et al. Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders. , 2009, Journal of Alzheimer's disease : JAD.
[133] Seung-Jae Lee,et al. Controlling the mass action of α‐synuclein in Parkinson’s disease , 2008, Journal of neurochemistry.
[134] B. Mollenhauer,et al. Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration , 2008, Experimental Neurology.
[135] E. Masliah,et al. Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases , 2008, PloS one.
[136] A. Eklund,et al. GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein , 2008, Proceedings of the National Academy of Sciences.
[137] Yoshihisa Watanabe,et al. Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro , 2008, Neuroscience Letters.
[138] R. Hauser,et al. Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease , 2008, Nature Medicine.
[139] T. Dawson. Faculty Opinions recommendation of A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. , 2008 .
[140] Elisabet Englund,et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation , 2008, Nature Medicine.
[141] T. Südhof,et al. A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides , 2008, Nature Neuroscience.
[142] A. Kakita,et al. Enhanced Accumulation of Phosphorylated α-Synuclein and Elevated β-Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 ΔT440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease , 2007, The Journal of Neuroscience.
[143] Joseph E LeDoux. The amygdala , 2007, Current Biology.
[144] I. Bertini,et al. Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains. , 2007, Journal of the American Chemical Society.
[145] A. Kakita,et al. Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease. , 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[146] T. Tokuda,et al. Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. , 2006 .
[147] K. Sode,et al. Effect of Reparation of Repeat Sequences in the Human α-Synuclein on Fibrillation Ability , 2006, International journal of biological sciences.
[148] J. Pettegrew,et al. Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease , 2006, Neurochemical Research.
[149] Dennis W. Dickson,et al. Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of &agr;-Synucleinopathy , 2006, Journal of neuropathology and experimental neurology.
[150] G. Schellenberg,et al. Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype. , 2006, Archives of neurology.
[151] Gina N. LaRossa,et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans , 2006, Annals of neurology.
[152] T. Duka,et al. Highly Potent and Specific GSK‐3β Inhibitors That Block Tau Phosphorylation and Decrease α‐Synuclein Protein Expression in a Cellular Model of Parkinson's Disease , 2006, ChemMedChem.
[153] T. Tokuda,et al. Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. , 2006, Biochemical and biophysical research communications.
[154] J. Pettegrew,et al. Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. , 2006, Neurochemical research.
[155] J. Morris,et al. Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life. , 2005, Archives of neurology.
[156] Thomas C. Südhof,et al. α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration , 2005, Cell.
[157] Ad Bax,et al. Structure and Dynamics of Micelle-bound Human α-Synuclein* , 2005, Journal of Biological Chemistry.
[158] C. Griesinger,et al. Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[159] S. Resnick,et al. Alpha-Synuclein Lesions in Normal Aging, Parkinson Disease, and Alzheimer Disease: Evidence from the Baltimore Longitudinal Study of Aging (BLSA) , 2005, Journal of neuropathology and experimental neurology.
[160] C. Dobson,et al. Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. , 2005, Journal of the American Chemical Society.
[161] T. Südhof,et al. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. , 2005, Cell.
[162] R. Hawkins,et al. α‐Synuclein produces a long‐lasting increase in neurotransmitter release , 2004, The EMBO journal.
[163] Giuseppe Battaglia,et al. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[164] J. Goudreau,et al. Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. , 2004, Neurotoxicology.
[165] Peter T. Lansbury,et al. Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy , 2004, Science.
[166] E. Iseki. Dementia with Lewy bodies: Reclassification of pathological subtypes and boundary with Parkinson's disease or Alzheimer's disease , 2004, Neuropathology : official journal of the Japanese Society of Neuropathology.
[167] J. Hoenicka,et al. The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia , 2004, Annals of neurology.
[168] Leonidas Stefanis,et al. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. , 2004, Science.
[169] A. Davies,et al. Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene , 2003, Molecular and Cellular Biology.
[170] Jie Li,et al. The Association of α-Synuclein with Membranes Affects Bilayer Structure, Stability, and Fibril Formation* , 2003, Journal of Biological Chemistry.
[171] H. Erdjument-Bromage,et al. Parkinson's Disease-associated α-Synuclein Is a Calmodulin Substrate* , 2003, The Journal of Biological Chemistry.
[172] J. Trojanowski,et al. Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein , 2003, Science.
[173] P. Lansbury,et al. The N-Terminal Repeat Domain of α-Synuclein Inhibits β-Sheet and Amyloid Fibril Formation† , 2003 .
[174] H. Erdjument-Bromage,et al. Parkinson's disease-associated alpha-synuclein is a calmodulin substrate. , 2003, The Journal of biological chemistry.
[175] P. Lansbury,et al. The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation. , 2003, Biochemistry.
[176] Chul-hak Yang,et al. Structural and Functional Implications of C-Terminal Regions of α-Synuclein† , 2002 .
[177] Richard Paylor,et al. Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein , 2002, The Journal of Neuroscience.
[178] Hong-Yu Hu,et al. Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation. , 2002, Biopolymers.
[179] Chul-hak Yang,et al. Structural and functional implications of C-terminal regions of alpha-synuclein. , 2002, Biochemistry.
[180] J. George,et al. The synucleins , 2001, Genome Biology.
[181] Makoto Hashimoto,et al. β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[182] J Q Trojanowski,et al. A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly* , 2001, The Journal of Biological Chemistry.
[183] G. Asano,et al. α-Synuclein-positive structures in cases with sporadic Alzheimer’s disease: morphology and its relationship to tau aggregation , 2001, Brain Research.
[184] L. Mucke,et al. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[185] T. Bayer,et al. Lewy body variant of Alzheimer's disease: α‐synuclein in dystrophic neurites of Aβ plaques , 2000 .
[186] J. Trojanowski,et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. , 2000, Science.
[187] R. Hamilton,et al. Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry , 2000, Brain pathology.
[188] J. Trojanowski,et al. Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons , 2000, The Journal of Neuroscience.
[189] K. Kosaka,et al. Occurrence of human α-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer’s disease , 2000, Journal of the Neurological Sciences.
[190] Heidi Phillips,et al. Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.
[191] K. Kosaka,et al. Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease. , 2000, Journal of the neurological sciences.
[192] D. Sulzer,et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. , 2000, Neuron.
[193] T. Bayer,et al. Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques. , 2000, Neuroreport.
[194] Michael Davis,et al. The amygdala , 2000, Current Biology.
[195] R. Schulz,et al. Caregiving as a risk factor for mortality: the Caregiver Health Effects Study. , 1999, JAMA.
[196] J. Trojanowski,et al. Antibodies to α‐synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease , 1999, Annals of neurology.
[197] J Q Trojanowski,et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. , 1998, The American journal of pathology.
[198] L. Thal,et al. Cognitive decline is faster in Lewy body variant than in Alzheimer's disease , 1998, Neurology.
[199] A. Jonas,et al. Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes* , 1998, The Journal of Biological Chemistry.
[200] Olaf Riess,et al. AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease , 1998, Nature Genetics.
[201] U. Igbavboa,et al. Lipid Binding to Amyloid β‐Peptide Aggregates: Preferential Binding of Cholesterol as Compared with Phosphatidylcholine and Fatty Acids , 1997, Journal of neurochemistry.
[202] Robert L. Nussbaum,et al. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .
[203] D. Wilson,et al. Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. , 1997, The American journal of pathology.
[204] S E Ide,et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. , 1997, Science.
[205] N. Guex,et al. SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling , 1997, Electrophoresis.
[206] D. Salmon,et al. The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s disease , 1996, Brain Research.
[207] K. Imahori,et al. Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[208] K. Imahori,et al. Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β , 1996, Neuroscience Letters.
[209] E. Masliah,et al. Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. , 1996, The American journal of pathology.
[210] David F. Clayton,et al. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch , 1995, Neuron.
[211] S. Lovestone,et al. Stimulation of MAP kinase by v‐raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau , 1995, FEBS letters.
[212] Akihiko Iwai,et al. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system , 1995, Neuron.
[213] D. Galasko,et al. Apolipoprotein-E ε-4 is associated with increased neurofibrillary pathology in the Lewy body variant of Alzheimer's disease , 1994, Neuroscience Letters.
[214] S. Shioda,et al. Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization. , 1994, Brain research. Molecular brain research.
[215] E. Masliah,et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[216] E. Masliah,et al. Plaque‐Only Alzheimer Disease is Usually the Lewy Body Variant, and Vice Versa , 1993, Journal of neuropathology and experimental neurology.
[217] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[218] J. Hardy,et al. Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.
[219] R. Scheller,et al. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. , 1991, Brain research. Molecular brain research.
[220] H. Braak,et al. Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections , 1991, Brain pathology.
[221] J. Woodgett,et al. Molecular cloning and expression of glycogen synthase kinase‐3/factor A. , 1990, The EMBO journal.
[222] L. Thal,et al. The Lewy body variant of Alzheimer's disease , 1990, Neurology.
[223] C. Bergeron,et al. Lewy Bodies in Alzheimer Disease‐One or Two Diseases? , 1989, Alzheimer disease and associated disorders.
[224] R. Scheller,et al. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[225] R. Brady,et al. THE METABOLISM OF GLUCOCEREBROSIDES. I. PURIFICATION AND PROPERTIES OF A GLUCOCEREBROSIDE-CLEAVING ENZYME FROM SPLEEN TISSUE. , 1965, The Journal of biological chemistry.