The extent of visual recovery from early monocular or binocular visual deprivation in kittens.

1. The rate and extent of recovery of vision was studied in the deprived eye of kittens that had been monocularly deprived from near birth for periods that lasted from 6 weeks to 18 months. Recovery was measured in the two situations, where either both eyes were open following the initial deprivation (binocular recovery), or else the non‐deprived eye was occluded so as to force the animal to employ its deprived eye (reverse occlusion). 2. Measurements were made of the visual acuity of the deprived eye for gratings at frequent intervals during recovery by means of a simple behavioural technique. 3. The acuity that the deprived eye eventually attained declined with increasing length of deprivation in a manner that could be approximated by a simple exponential decay. Only minimal visual recovery was observed in animals deprived beyond 1 year of age; only two of six animals recovered sufficient vision to enable measurement of visual acuity. In general, animals that were reverse occluded recovered better vision than did those that had both eyes open during recovery. 4. The recovery of vision in the deprived eye of monocularly deprived kittens was compared to that observed following equivalent periods of two forms of binocular deprivation, namely dark‐rearing and binocular eyelid suture. 5. The recovery from the two forms of binocular deprivation was quite different. Whereas the extent of recovery from dark‐rearing was considerably greater than that observed after equivalent periods of monocular deprivation, the recovery of a limited sample of cats that were binocularly deprived by eyelid suture was worse. 6. These findings suggest that some plasticity remains in the visual pathways for a longer time than indicated by experiments that examine the physiological effects of monocular deprivation on various visual cortical structures.

[1]  D. Hubel,et al.  SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE. , 1963, Journal of neurophysiology.

[2]  D. Hubel,et al.  Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. , 1965, Journal of neurophysiology.

[3]  L Ganz,et al.  The effect of visual deprivation on perceptual behavior. , 1968, Experimental neurology.

[4]  D. Hubel,et al.  The period of susceptibility to the physiological effects of unilateral eye closure in kittens , 1970, The Journal of physiology.

[5]  T. Wiesel,et al.  Consequences of monocular deprivation on visual behaviour in kittens , 1970, The Journal of physiology.

[6]  G. Rizzolatti,et al.  Pattern discrimination in monocularly reared cats. , 1971, Experimental neurology.

[7]  H. Hirsch,et al.  The nature of perceptual deficits in visually deprived cats. , 1972, Brain research.

[8]  D. L. Stewart,et al.  Reversal of structural and functional effects of long-term visual deprivation in cats. , 1972, Experimental neurology.

[9]  C. Blakemore,et al.  Reversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period , 1974, The Journal of physiology.

[10]  R. Marc,et al.  Light transmission of cat and monkey eyelids , 1976, Vision Research.

[11]  J. Movshon.  Reversal of the physiological effects of monocular deprivation in the kitten's visual cortex. , 1976, The Journal of physiology.

[12]  S. Sherman,et al.  Visual discriminations during eyelid closure in the cat , 1977, Brain Research.

[13]  D E Mitchell,et al.  A Behavioural Technique for the Rapid Assessment of the Visual Capabilities of Kittens , 1977, Perception.

[14]  D. Mitchell,et al.  Recovery from the effects of monocular deprivation in kittens , 1977, The Journal of comparative neurology.

[15]  D E Mitchell,et al.  The rate of recovery of vision after early monocular deprivation in kittens , 1978, The Journal of physiology.

[16]  P. D. Spear,et al.  Striate cortex neurons of binocularly deprived kittens respond to visual stimuli through the closed eyelids , 1978, Brain Research.

[17]  R. Freeman,et al.  Monocular deprivation and recovery during sensitive period in kittens. , 1978, Journal of neurophysiology.

[18]  C. Blakemore,et al.  The physiological effects of monocular deprivation and their reversal in the monkey's visual cortex. , 1978, The Journal of physiology.

[19]  M. Berkley,et al.  Striate cortex and visual acuity functions in the cat , 1979, The Journal of comparative neurology.

[20]  F. Wilkinson.  Reversal of the behavioural effects of monocular deprivation as a function of age in the kitten , 1980, Behavioural Brain Research.

[21]  D E Mitchell,et al.  Prolonged sensitivity to monocular deprivation in dark-reared cats. , 1980, Journal of neurophysiology.

[22]  D. Hubel,et al.  The development of ocular dominance columns in normal and visually deprived monkeys , 1980, The Journal of comparative neurology.

[23]  D. Mitchell,et al.  Period of susceptibility of kitten visual cortex to the effects of monocular deprivation extends beyond six months of age , 1980, Brain Research.

[24]  D E Mitchell,et al.  Behavioral evidence for prolonged sensitivity to effects of monocular deprivation in dark-reared cats. , 1980, Journal of neurophysiology.

[25]  Douglas C. Smith,et al.  Visual acuity following binocular deprivation in the cat , 1980, Brain Research.

[26]  C. Blakemore,et al.  Recovery from monocular deprivation in the monkey. I. Reversal of physiological effects in the visual cortex , 1981, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[27]  D. Mitchell,et al.  Depth perception, eye alignment and cortical ocular dominance of dark-related cats. , 1981, Brain research.

[28]  M. Berkley.  6 – Animal Models of Visual Development: Behavioral Evaluation of Some Physiological Findings in Cat Visual Development , 1981 .

[29]  D. Mitchell,et al.  Selective loss of binocular depth perception after ablation of cat visual cortex , 1981, Nature.

[30]  Frank H. Duffy,et al.  Comparison of the effects of dark rearing and binocular suture on development and plasticity of cat visual cortex , 1981, Brain Research.

[31]  Acuity, luminance, and monocular deprivation in the cat , 1981, Behavioural Brain Research.

[32]  S. Sherman,et al.  Spatial and temporal sensitivity of normal and amblyopic cats. , 1982, Journal of neurophysiology.

[33]  D M Levi,et al.  Differences in vernier discrimination for grating between strabismic and anisometropic amblyopes. , 1982, Investigative ophthalmology & visual science.

[34]  G. Mower,et al.  Behavioral recovery from binocular deprivation in the cat , 1982, Behavioural Brain Research.

[35]  Earl L. Smith,et al.  Behavioral studies on the effect of abnormal early visual experience in monkeys: Spatial modulation sensitivity , 1983, Vision Research.

[36]  K. Kratz,et al.  Spatial contrast sensitivity of monocularly deprived cats after removal of the non-deprived eye , 1983, Behavioural Brain Research.

[37]  E. Smith,et al.  Behavioral studies on the effect of abnormal early visual experience in monkeys: Temporal modulation sensitivity , 1983, Vision Research.

[38]  D. Mitchell,et al.  Contrast thresholds for sine gratings of children with amblyopia. , 1983, Investigative ophthalmology & visual science.

[39]  D. Mitchell,et al.  The permanence of the visual recovery that follows reverse occlusion of monocularly deprived kittens. , 1984, Investigative ophthalmology & visual science.

[40]  P. D. Spear,et al.  Critical periods for effects of monocular deprivation: differences between striate and extrastriate cortex , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[41]  Douglas C. Smith,et al.  Binocular competitive interactions and recovery of visual acuity in long-term monocularly deprived cats , 1985, Vision Research.

[42]  D. Mitchell,et al.  Reduced visual acuity in both eyes of monocularly deprived kittens following a short or long period of reverse occlusion , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.