N -substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study
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[1] M. Pudlo,et al. Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease. , 2014, Bioorganic & medicinal chemistry.
[2] A. Shafiee,et al. Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. , 2013, European journal of medicinal chemistry.
[3] P. Nordlund,et al. Fragment-based ligand design of novel potent inhibitors of tankyrases. , 2013, Journal of medicinal chemistry.
[4] P. Agostinho,et al. Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity. , 2013, ACS chemical neuroscience.
[5] D. Dougherty. The cation-π interaction. , 2013, Accounts of chemical research.
[6] José Marco-Contelles,et al. Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease , 2013, Medicinal research reviews.
[7] M. Rudolph,et al. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. , 2012, Journal of medicinal chemistry.
[8] M. Decker,et al. Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo. , 2012, Journal of medicinal chemistry.
[9] V. Andrisano,et al. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. , 2011, European journal of medicinal chemistry.
[10] M. Al-Omar,et al. Synthesis, antiplatelet aggregation activity, and molecular modeling study of novel substituted-piperazine analogues , 2011, Medicinal Chemistry Research.
[11] H. Jacobsen,et al. Alzheimer's disease: from pathology to therapeutic approaches. , 2009, Angewandte Chemie.
[12] L. Wessjohann,et al. (Iso)-quinoline alkaloids from fungal fruiting bodies of Cortinarius subtortus. , 2008, Journal of natural products.
[13] J. Trojanowski,et al. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.
[14] G. Perry,et al. Prevention and treatment of Alzheimer disease and aging: antioxidants. , 2007, Mini reviews in medicinal chemistry.
[15] S. Moore,et al. The peripheral anionic site of acetylcholinesterase: structure, functions and potential role in rational drug design. , 2006, Current pharmaceutical design.
[16] Hiroaki Kazui,et al. Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease? , 2005, The American journal of psychiatry.
[17] Charles L. Brooks,et al. Detailed analysis of grid‐based molecular docking: A case study of CDOCKER—A CHARMm‐based MD docking algorithm , 2003, J. Comput. Chem..
[18] Ian D. Williams,et al. Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product , 2000 .
[19] J. Sussman,et al. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. , 1999, Structure.
[20] G. Wilcock,et al. The cholinergic hypothesis of Alzheimer’s disease: a review of progress , 1999, Journal of neurology, neurosurgery, and psychiatry.
[21] R B D'Agostino,et al. Lifetime risk of dementia and Alzheimer's disease , 1997, Neurology.
[22] J. Sussman,et al. Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs. , 1993, Chemico-biological interactions.
[23] A. Gader,et al. A Study of the Normal Pattern of Platelet Aggregation in Healthy Saudis: A Population-based Study. , 1990, Platelets.
[24] A. Gader,et al. Dose-Response Aggregometry in Maternal/Neonatal Platelets , 1988, Thrombosis and Haemostasis.