Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

[1]  N. Volkow,et al.  Neurocircuitry of Addiction , 2010, Neuropsychopharmacology.

[2]  D. van der Kooy,et al.  VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation , 2014, Nature Neuroscience.

[3]  S. William Expression profiling of brain structures of dependent and non-dependent rats self-administering alcohol and naive controls (Cleaner Normalized) , 2014 .

[4]  D. H. Root,et al.  Role of Glutamatergic Projections from Ventral Tegmental Area to Lateral Habenula in Aversive Conditioning , 2014, The Journal of Neuroscience.

[5]  Mariano J. Alvarez,et al.  Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks , 2014, Cell.

[6]  Mariano J. Alvarez,et al.  Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. , 2014, Cancer cell.

[7]  A. Roberts,et al.  Operant alcohol self-administration in dependent rats: focus on the vapor model. , 2014, Alcohol.

[8]  Anne E Carpenter,et al.  ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. , 2014, Cell reports.

[9]  Andrea Califano,et al.  Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. , 2013, Cancer cell.

[10]  David J. Arenillas,et al.  JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles , 2013, Nucleic Acids Res..

[11]  J. Espinosa,et al.  ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1 , 2013, Nucleic acids research.

[12]  G. Koob,et al.  Corticosteroid-Dependent Plasticity Mediates Compulsive Alcohol Drinking in Rats , 2012, The Journal of Neuroscience.

[13]  Andrea Califano,et al.  Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL , 2011, Nature Medicine.

[14]  Xuerui Yang,et al.  An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma , 2011, Cell.

[15]  Alice M Stamatakis,et al.  Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. , 2011, Nature.

[16]  P. Barnes Glucocorticosteroids: current and future directions , 2011, British journal of pharmacology.

[17]  G. Koob,et al.  Preclinical studies of alcohol binge drinking , 2011, Annals of the New York Academy of Sciences.

[18]  Fair M. Vassoler,et al.  Ventral Tegmental Afferents in Stress-Induced Reinstatement: The Role of cAMP Response Element-Binding Protein , 2010, The Journal of Neuroscience.

[19]  Mariano J. Alvarez,et al.  A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers , 2010, Molecular systems biology.

[20]  L. Parsons,et al.  Corticotropin Releasing Factor–Induced Amygdala Gamma-Aminobutyric Acid Release Plays a Key Role in Alcohol Dependence , 2010, Biological Psychiatry.

[21]  J. Crabbe,et al.  REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? , 2010, Addiction biology.

[22]  Mariano J. Alvarez,et al.  Correlating measurements across samples improves accuracy of large-scale expression profile experiments , 2009, Genome Biology.

[23]  G. Koob,et al.  Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. , 2009, Alcoholism, clinical and experimental research.

[24]  C. Blaha,et al.  Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: A molecular equilibrium in the midbrain? , 2009, Synapse.

[25]  Mariano J. Alvarez,et al.  Genome-wide Identification of Post-translational Modulators of Transcription Factor Activity in Human B-Cells , 2009, Nature Biotechnology.

[26]  Wei Keat Lim,et al.  The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. , 2009, Developmental cell.

[27]  R. Dalla‐Favera,et al.  Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma , 2009, Nature.

[28]  G. Koob,et al.  Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis , 2009, The Journal of Neuroscience.

[29]  J. Williams,et al.  Morphine produces circuit-specific neuroplasticity in the bed nucleus of the stria terminalis , 2008, Neuroscience.

[30]  A. Hansson,et al.  Neuroplasticity in brain reward circuitry following a history of ethanol dependence , 2008, The European journal of neuroscience.

[31]  G. Koob,et al.  MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist , 2008, Pharmacology Biochemistry and Behavior.

[32]  K. Basso,et al.  A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas , 2008, Molecular systems biology.

[33]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Adam A. Margolin,et al.  Reverse engineering of regulatory networks in human B cells , 2005, Nature Genetics.

[35]  G. Koob,et al.  Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. , 2004, Alcoholism, clinical and experimental research.

[36]  Chris Wiggins,et al.  ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context , 2004, BMC Bioinformatics.

[37]  P. Kalivas,et al.  Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior , 2004, The Journal of Neuroscience.

[38]  Jun S. Liu,et al.  Integrating regulatory motif discovery and genome-wide expression analysis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[39]  P. Sanna,et al.  ERK regulation in chronic ethanol exposure and withdrawal , 2002, Brain Research.

[40]  E. Butelman,et al.  Pharmacotherapy of addictions , 2002, Nature Reviews Drug Discovery.

[41]  G. Koob,et al.  Drug Addiction, Dysregulation of Reward, and Allostasis , 2001, Neuropsychopharmacology.

[42]  C. Heyser,et al.  Excessive Ethanol Drinking Following a History of Dependence: Animal Model of Allostasis , 2000, Neuropsychopharmacology.

[43]  C. Fahlke,et al.  Effect of local intracerebral corticosterone implants on alcohol intake in the rat. , 1999, Alcohol and alcoholism.

[44]  K. Cho,et al.  Effects of corticosterone on excitatory amino acid responses in dopamine-sensitive neurons in the ventral tegmental area , 1999, Neuroscience.

[45]  K. Nader,et al.  Deprivation State Switches the Neurobiological Substrates Mediating Opiate Reward in the Ventral Tegmental Area , 1997, The Journal of Neuroscience.

[46]  F. Rougé-Pont,et al.  Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. Pistis,et al.  Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[48]  G. Koob Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. , 2013, Current topics in behavioral neurosciences.

[49]  J. Uhm,et al.  The transcriptional network for mesenchymal transformation of brain tumours , 2010 .

[50]  S. Zakhari,et al.  Commentary: Systems Biology and Its Relevance to Alcohol Research , 2008, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[51]  Xin Chen,et al.  TRANSFAC: an integrated system for gene expression regulation , 2000, Nucleic Acids Res..