Reactive oxygen species: influence on cerebral vascular tone.

Reactive oxygen species have multiple effects on vascular cells. Defining the sources and the impact of the various reactive oxygen species within the vessel wall has emerged as a major area of study in vascular biology. This review will focus on recent findings related to effects of reactive oxygen species on cerebral vascular tone. Effects of superoxide radical, hydrogen peroxide, and the reactive nitrogen species peroxynitrite are summarized. Although higher concentrations may be important for cerebral vascular biology in disease, relatively low concentrations of reactive oxygen species may function as signaling molecules involved with normal regulation of cerebral vascular tone. The mechanisms by which reactive oxygen species affect vascular tone may be quite complex, and our understanding of these processes is increasing. Additionally, the role of reactive oxygen species as mediators of endothelium-dependent relaxation is addressed. Finally, the consequences of the molecular interactions of superoxide with nitric oxide and arachidonic acid are discussed.

[1]  H. Cai Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences. , 2005, Cardiovascular research.

[2]  J. Jaggar,et al.  Mitochondria-Derived Reactive Oxygen Species Dilate Cerebral Arteries by Activating Ca2+ Sparks , 2005, Circulation research.

[3]  R. Bryan,et al.  Endothelium-derived Hyperpolarizing Factor: A Cousin to Nitric Oxide and Prostacyclin , 2005, Anesthesiology.

[4]  P. Ray,et al.  NF-&kgr;B Activation Plays a Role in Superoxide-Mediated Cerebral Endothelial Dysfunction After Hypoxia/Reoxygenation , 2005, Stroke.

[5]  R. Bryan,et al.  Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries. , 2005, American journal of physiology. Heart and circulatory physiology.

[6]  F. Faraci,et al.  Impaired Endothelium-Dependent Responses and Enhanced Influence of Rho-Kinase in Cerebral Arterioles in Type II Diabetes , 2005, Stroke.

[7]  F. Faraci Oxidative stress: the curse that underlies cerebral vascular dysfunction? , 2005, Stroke.

[8]  J. Morrow Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[9]  M. Runge,et al.  Oxidative Stress and Vascular Disease , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[10]  D. Harrison,et al.  Redox Mechanisms in Blood Vessels , 2004 .

[11]  G. Wang,et al.  Exogenous NADPH Increases Cerebral Blood Flow Through NADPH Oxidase–Dependent and –Independent Mechanisms , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[12]  T. Bottiglieri,et al.  Cerebral Vascular Dysfunction Mediated by Superoxide in Hyperhomocysteinemic Mice , 2004, Stroke.

[13]  F. Faraci,et al.  Vascular protection: superoxide dismutase isoforms in the vessel wall. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[14]  Hiroaki Shimokawa,et al.  Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. , 2004, Pharmacological research.

[15]  J. Jaggar,et al.  Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries , 2004, The Journal of physiology.

[16]  J. Snipes,et al.  Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C. , 2004, Diabetes.

[17]  B. Altura,et al.  Peroxynitrite-induced relaxation in isolated canine cerebral arteries and mechanisms of action. , 2004, Toxicology and applied pharmacology.

[18]  C. Iadecola,et al.  Aβ-Induced Vascular Oxidative Stress and Attenuation of Functional Hyperemia in Mouse Somatosensory Cortex , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  Brenton Milner,et al.  Sciatic nerve entrapment in the upper thigh caused by an injury sustained during World War II at the battle of Anzio. Case report. , 2004, Journal of Neurosurgery.

[20]  R. P. Jewell,et al.  Inhibition of Ca++ sparks by oxyhemoglobin in rabbit cerebral arteries. , 2004, Journal of neurosurgery.

[21]  C. Sobey,et al.  Increased NADPH-Oxidase Activity and Nox4 Expression During Chronic Hypertension Is Associated With Enhanced Cerebral Vasodilatation to NADPH In Vivo , 2004, Stroke.

[22]  L. Roberts,et al.  Isomer-specific contractile effects of a series of synthetic f2-isoprostanes on retinal and cerebral microvasculature. , 2004, Free radical biology & medicine.

[23]  H. Maeda,et al.  Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. , 2003, The Journal of clinical investigation.

[24]  D. Edwards,et al.  Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Krause,et al.  17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation. , 2003, American journal of physiology. Heart and circulatory physiology.

[26]  D. Heistad,et al.  Gene Transfer of Extracellular Superoxide Dismutase Reduces Cerebral Vasospasm After Subarachnoid Hemorrhage , 2003, Stroke.

[27]  N. Saito,et al.  Contractile Responses to Reactive Oxygen Species in the Canine Basilar Artery in Vitro: Selective Inhibitory Effect of MCI-186, a new Hydroxyl Radical Scavenger , 2002, Acta Neurochirurgica.

[28]  C. Sigmund,et al.  Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice , 2002, Circulation research.

[29]  Dong Eun Kim,et al.  Vascular NAD(P)H Oxidase Triggers Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage in Rats , 2002, Stroke.

[30]  J. Cracowski,et al.  Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications. , 2002, Trends in pharmacological sciences.

[31]  B. Kis,et al.  Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin. , 2002, American journal of physiology. Heart and circulatory physiology.

[32]  F. Faraci,et al.  Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. , 2002, American journal of physiology. Heart and circulatory physiology.

[33]  D. Cornfield,et al.  Aβ-peptides enhance vasoconstriction in cerebral circulation , 2001 .

[34]  F. Faraci,et al.  Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. , 2001, American journal of physiology. Heart and circulatory physiology.

[35]  W. Mayhan,et al.  Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals. , 2001, American journal of physiology. Heart and circulatory physiology.

[36]  D. Prough,et al.  Peroxynitrite Reduces Vasodilatory Responses to Reduced Intravascular Pressure, Calcitonin Gene-Related Peptide, and Cromakalim in Isolated Middle Cerebral Arteries , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[37]  S. J. Elliott,et al.  Peroxynitrite reversibly inhibits Ca(2+)-activated K(+) channels in rat cerebral artery smooth muscle cells. , 2000, American journal of physiology. Heart and circulatory physiology.

[38]  N. Abbott Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability , 2000, Cellular and Molecular Neurobiology.

[39]  E. Ellis,et al.  Augmented vasoconstriction and thromboxane formation by 15-F(2t)-isoprostane (8-iso-prostaglandin F(2alpha)) in immature pig periventricular brain microvessels. , 2000, Stroke.

[40]  C. Epstein,et al.  Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase. , 1999, Stroke.

[41]  C. Sobey,et al.  Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate. , 1998, American journal of physiology. Heart and circulatory physiology.

[42]  S. J. Elliott,et al.  Peroxynitrite is a contractile agonist of cerebral artery smooth muscle cells. , 1998, The American journal of physiology.

[43]  B. Altura,et al.  Endothelium-dependent relaxation to hydrogen peroxide in canine basilar artery: a potential new cerebral dilator mechanism , 1998, Brain Research Bulletin.

[44]  Z. Katušić,et al.  Mechanisms of Cerebral Arterial Relaxations to Hydrogen Peroxide , 1998, Stroke.

[45]  C. Sobey,et al.  Mechanisms of bradykinin-induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channels. , 1997, Stroke.

[46]  E. Ellis,et al.  Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles. , 1997, Stroke.

[47]  J S Beckman,et al.  Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. , 1996, The American journal of physiology.

[48]  K. Nagata,et al.  Superoxide anions in the pathogenesis of talc‐induced cerebraI vasocontraction , 1995, Neuropathology and applied neurobiology.

[49]  L. Sanz,et al.  Different influence of superoxide anions and hydrogen peroxide on endothelial function of isolated cat cerebral and pulmonary arteries. , 1994, General pharmacology.

[50]  Z. Katušić,et al.  Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery. , 1993, The American journal of physiology.

[51]  D. Heistad,et al.  Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats. , 1991, Stroke.

[52]  H. Kontos,et al.  H2O2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine. , 1990, Hypertension.

[53]  W. Armstead,et al.  H2O2 effects on cerebral prostanoids and pial arteriolar diameter in piglets. , 1990, The American journal of physiology.

[54]  H. Kontos,et al.  In vivo bioassay of endothelium-derived relaxing factor. , 1988, The American journal of physiology.

[55]  H. Kontos,et al.  Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide. , 1988, The American journal of physiology.

[56]  W. Rosenblum Hydroxyl Radical Mediates the Endothelium‐Dependent Relaxation Produced by Bradykinin in Mouse Cerebral Arterioles , 1987, Circulation research.

[57]  W. Rosenblum Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles. , 1986, Stroke.

[58]  J. Povlishock,et al.  Oxygen Radicals Mediate the Cerebral Arteriolar Dilation from Arachidonate and Bradykinin in Cats , 1984, Circulation research.

[59]  W. Rosenblum Effects of free radical generation on mouse pial arterioles: probable role of hydroxyl radicals. , 1983, The American journal of physiology.

[60]  W. Dröge Free radicals in the physiological control of cell function. , 2002, Physiological reviews.

[61]  P. Vanhoutte Endothelium-derived free radicals: for worse and for better. , 2001, The Journal of clinical investigation.

[62]  D. Heistad,et al.  Regulation of the cerebral circulation: role of endothelium and potassium channels. , 1998, Physiological reviews.

[63]  F. Faraci,et al.  Regulation of the cerebral circulation by endothelium. , 1992, Pharmacology & therapeutics.

[64]  C. Sobey,et al.  Journal of Cerebral Blood Flow and Metabolism Role of Potassium Channels in Regulation of Cerebral Vascular Tone , 2022 .