In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol

[1]  B. Blough,et al.  Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV) , 2014, Neuropharmacology.

[2]  Rui Moreira,et al.  Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal. , 2014, Forensic science international.

[3]  S. Elliott,et al.  A 3-year review of new psychoactive substances in casework. , 2014, Forensic science international.

[4]  D. Favretto,et al.  A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case. , 2014, Forensic science international.

[5]  M. Meyer,et al.  Studies on the microbial biotransformation of the novel psychoactive substance methylenedioxypyrovalerone (MDPV) in wastewater by means of liquid chromatography-high resolution mass spectrometry/mass spectrometry. , 2014, The Science of the total environment.

[6]  L. King,et al.  The new drug phenomenon. , 2014, Drug testing and analysis.

[7]  S. Rana,et al.  Testing for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urine. , 2014, Journal of analytical toxicology.

[8]  Kayla N. Ellefsen,et al.  3,4-Methylenedioxypyrovalerone (MDPV) and metabolites quantification in human and rat plasma by liquid chromatography-high resolution mass spectrometry. , 2014, Analytica chimica acta.

[9]  O. Suzuki,et al.  Postmortem distribution of α-pyrrolidinovalerophenone and its metabolite in body fluids and solid tissues in a fatal poisoning case measured by LC–MS–MS with the standard addition method , 2014, Forensic Toxicology.

[10]  C. Herrmann,et al.  Analysis of new designer drugs and common drugs of abuse in urine by a combined targeted and untargeted LC-HR-QTOFMS approach , 2014, Analytical and Bioanalytical Chemistry.

[11]  Adrian Covaci,et al.  Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances , 2014 .

[12]  Ken-ichi Yoshida,et al.  Sudden death after sustained restraint following self-administration of the designer drug α-pyrrolidinovalerophenone. , 2014, International journal of cardiology.

[13]  A. Pelander,et al.  In silico and in vitro metabolism studies support identification of designer drugs in human urine by liquid chromatography/quadrupole-time-of-flight mass spectrometry , 2013, Analytical and Bioanalytical Chemistry.

[14]  S. Johansen,et al.  In vitro metabolism studies on mephedrone and analysis of forensic cases. , 2013, Drug testing and analysis.

[15]  H. Shiraishi,et al.  A fatal case of 3,4-methylenedioxypyrovalerone poisoning: coexistence of α-pyrrolidinobutiophenone and α-pyrrolidinovalerophenone in blood and/or hair , 2013, Forensic Toxicology.

[16]  D. Favretto,et al.  New challenges and innovation in forensic toxicology: focus on the "New Psychoactive Substances". , 2013, Journal of chromatography. A.

[17]  Shaena Taylor,et al.  Postmortem tissue distribution of MDPV following lethal intoxication by "bath salts". , 2013, Journal of analytical toxicology.

[18]  Kurt R. Lehner,et al.  Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products , 2013, Neuropsychopharmacology.

[19]  C. Davidson New psychoactive substances , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[20]  J. Warner,et al.  LC-MS/MS method for the quantitation of metabolites of eight commonly-used synthetic cannabinoids in human urine--an Australian perspective. , 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[21]  G. Siuzdak,et al.  XCMS Online: a web-based platform to process untargeted metabolomic data. , 2012, Analytical chemistry.

[22]  Lewis S. Nelson,et al.  The Toxicology of Bath Salts: A Review of Synthetic Cathinones , 2012, Journal of Medical Toxicology.

[23]  Dariusz Zuba,et al.  Identification of cathinones and other active components of ‘legal highs’ by mass spectrometric methods , 2012 .

[24]  Brittany L. Murray,et al.  Death Following Recreational Use of Designer Drug “Bath Salts” Containing 3,4-Methylenedioxypyrovalerone (MDPV) , 2012, Journal of Medical Toxicology.

[25]  K. Rentsch,et al.  Generation of metabolites by an automated online metabolism method using human liver microsomes with subsequent identification by LC-MS(n), and metabolism of 11 cathinones , 2012, Analytical and Bioanalytical Chemistry.

[26]  M. Coppola,et al.  3,4-methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. , 2012, Toxicology letters.

[27]  M. Meyer,et al.  Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS. , 2010, Journal of mass spectrometry : JMS.

[28]  Maria Wikström,et al.  Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone). , 2010, Journal of analytical toxicology.

[29]  Dominic P. Williams,et al.  Acyl glucuronides: the good, the bad and the ugly. , 2010, Biopharmaceutics & drug disposition.

[30]  X. de la Torre,et al.  Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry. , 2010, Rapid communications in mass spectrometry : RCM.

[31]  Frank T Peters,et al.  Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry , 2010, Analytical and bioanalytical chemistry.

[32]  M. Meyer,et al.  New designer drug alpha-pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. , 2009, Journal of mass spectrometry : JMS.

[33]  Jennifer L. Martin,et al.  Human sulfotransferases and their role in chemical metabolism. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[34]  K. Sasaki,et al.  Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites , 2013, Forensic Toxicology.

[35]  A. Ishii,et al.  Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: a review of their pharmacology, acute toxicity, and metabolism , 2013, Forensic Toxicology.

[36]  R. Tukey,et al.  Human UDP-glucuronosyltransferases: metabolism, expression, and disease. , 2000, Annual review of pharmacology and toxicology.