Paternal occupational exposures and childhood cancer.

The objective of the study described here was to test the hypothesis that paternal occupational exposure near conception increases the risk of cancer in the offspring. We conducted a cohort study based on a population of 235,635 children born shortly after two different censuses in Sweden. The children were followed from birth to 14 years, and cases of cancer were identified in the Swedish Cancer Registry. Occupational hygienists assessed the probability of exposure to different agents in each combination of the father's industry and occupation as reported in the censuses. We also analyzed individual job titles. We compared the cancer incidence among children of exposed fathers to that among children of unexposed fathers using Cox proportional hazards modeling. The main findings were an increased risk of nervous system tumors related to paternal occupational exposure to pesticides [relative risk (RR) = 2.36; 95% confidence interval (CI), 1.27-4.39] and work as a painter (RR = 3.65; 95% CI, 1.71-7.80), and an increased risk of leukemia related to wood work by fathers (RR = 2.18; 95% CI, 1.26-3.78). We found no associations between childhood leukemia and paternal exposure to pesticides or paint. Our results support previous findings of an increased risk of childhood brain tumors and leukemia associated with certain paternal occupational exposures. Some findings in previous studies were not confirmed in this study.

[1]  D. Sinnett,et al.  Preconceptional paternal exposure to pesticides and increased risk of childhood leukaemia , 1999, The Lancet.

[2]  M. Ward,et al.  Pesticides and childhood cancer. , 1998, Environmental health perspectives.

[3]  A. Blair,et al.  Parental occupational exposures and risk of childhood cancer. , 1998, Environmental health perspectives.

[4]  A. Olshan,et al.  Pesticides and childhood cancers. , 1997, Environmental health perspectives.

[5]  J. Michaelis,et al.  Childhood leukaemia and exposure to pesticides: results of a case-control study in northern Germany. , 1996, European journal of cancer.

[6]  A. Andersen,et al.  Cancer in offspring of parents engaged in agricultural activities in Norway: Incidence and risk factors in the farm environment , 1996, International journal of cancer.

[7]  Karen Steindorf,et al.  Results of a case-control study on previous infections and other risk factors for ischemic cerebrovascular diseases: attributable and absolute risks , 1996, GMDS.

[8]  C. Hogstedt,et al.  Neuropsychiatric function of housepainters with previous long-term heavy exposure to organic solvents. , 1995, Scandinavian Journal of Work, Environment and Health.

[9]  N. Plato,et al.  Fiber exposure assessment in the Swedish rock wool and slag wool production industry in 1938-1990. , 1995, Scandinavian journal of work, environment & health.

[10]  D. Hémon,et al.  Incidence and risk factors for childhood brain tumors in the ILE DE France , 1994, International journal of cancer.

[11]  L. Tomatis.  Transgeneration Carcinogenesis: A Review of the Experimental and Epidemiological Evidence , 1994, Japanese journal of cancer research : Gann.

[12]  V. Beral,et al.  Case-control study of leukaemia and non-Hodgkin's lymphoma among children aged 0-4 years living in west Berkshire and north Hampshire health districts. , 1993, BMJ.

[13]  N Plato,et al.  Methodology and utility of a job-exposure matrix. , 1993, American journal of industrial medicine.

[14]  C. Nass,et al.  Parental occupation and childhood astrocytoma: results of a case-control study. , 1992, Cancer research.

[15]  J. Olsen,et al.  Parental employment at time of conception and risk of cancer in offspring. , 1991, European journal of cancer.

[16]  F E Alexander,et al.  Parental occupations of children with leukaemia in west Cumbria, north Humberside, and Gateshead. , 1991, BMJ.

[17]  C. Magnani,et al.  Parental Occupation and Other Environmental Factors in the Etiology of Leukemias and Non-Hodgkin'S Lymphomas in Childhood: A Case-Control Study , 1990, Tumori.

[18]  J. R. Wilkins,et al.  Parental occupation and intracranial neoplasms of childhood: results of a case-control interview study. , 1990, American journal of epidemiology.

[19]  D. Savitz,et al.  Parental occupation and childhood cancer: review of epidemiologic studies. , 1990, Environmental health perspectives.

[20]  S. Skerfving,et al.  Deaths and tumours among rotogravure printers exposed to toluene. , 1990, British journal of industrial medicine.

[21]  A J Hall,et al.  Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. , 1990, BMJ.

[22]  J. Buckley,et al.  Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. , 1989, Cancer research.

[23]  G. Steineck,et al.  Industry-related urothelial carcinogens: application of a job-exposure matrix to census data. , 1989, American journal of industrial medicine.

[24]  J. Fraumeni,et al.  A population-based case-control study of childhood leukemia in Shanghai , 1990 .

[25]  M. Spitz,et al.  Childhood nervous system tumors--an evaluation of the association with paternal occupational exposure to hydrocarbons. , 1987, American journal of epidemiology.

[26]  E. Rappaport,et al.  Childhood leukemia and parents' occupational and home exposures. , 1987, Journal of the National Cancer Institute.

[27]  H. Valkenburg,et al.  Childhood leukemia and parental occupation. A register-based case-control study. , 1985, American journal of epidemiology.

[28]  J. Rowley.  Report of Children's Cancer Study Group. , 1985, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  B Mattsson,et al.  Completeness of the Swedish Cancer Register. Non-notified cancer cases recorded on death certificates in 1978. , 1984, Acta radiologica. Oncology.

[30]  S. Preston‐Martin,et al.  Brain tumors in children and occupational exposure of parents. , 1981, Science.

[31]  K. Hemminki,et al.  Childhood cancer and parental occupation in Finland. , 1981, Journal of epidemiology and community health.

[32]  A. Herbst,et al.  Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. , 1971, The New England journal of medicine.