Manipulation or mobilisation for neck pain.

BACKGROUND Manipulation and mobilisation are often used, either alone or combined with other treatment approaches, to treat neck pain. OBJECTIVES To assess if manipulation or mobilisation improves pain, function/disability, patient satisfaction, quality of life, and global perceived effect in adults with acute/subacute/chronic neck pain with or without cervicogenic headache or radicular findings. SEARCH STRATEGY CENTRAL (The Cochrane Library 2009, issue 3) and MEDLINE, EMBASE, Manual Alternative and Natural Therapy, CINAHL, and Index to Chiropractic Literature were updated to July 2009. SELECTION CRITERIA Randomised controlled trials on manipulation or mobilisation. DATA COLLECTION AND ANALYSIS Two review authors independently selected studies, abstracted data, and assessed risk of bias. Pooled relative risk and standardised mean differences (SMD) were calculated. MAIN RESULTS We included 27 trials (1522 participants).Cervical Manipulation for subacute/chronic neck pain : Moderate quality evidence suggested manipulation and mobilisation produced similar effects on pain, function and patient satisfaction at intermediate-term follow-up. Low quality evidence showed manipulation alone compared to a control may provide short- term relief following one to four sessions (SMD pooled -0.90 (95%CI: -1.78 to -0.02)) and that nine or 12 sessions were superior to three for pain and disability in cervicogenic headache. Optimal technique and dose need to be determined.Thoracic Manipulation for acute/chronic neck pain : Low quality evidence supported thoracic manipulation as an additional therapy for pain reduction (NNT 7; 46.6% treatment advantage) and increased function (NNT 5; 40.6% treatment advantage) in acute pain and favoured a single session of thoracic manipulation for immediate pain reduction compared to placebo for chronic neck pain (NNT 5, 29% treatment advantage).Mobilisation for subacute/chronic neck pain: In addition to the evidence noted above, low quality evidence for subacute and chronic neck pain indicated that 1) a combination of Maitland mobilisation techniques was similar to acupuncture for immediate pain relief and increased function; 2) there was no difference between mobilisation and acupuncture as additional treatments for immediate pain relief and improved function; and 3) neural dynamic mobilisations may produce clinically important reduction of pain immediately post-treatment. Certain mobilisation techniques were superior. AUTHORS' CONCLUSIONS Cervical manipulation and mobilisation produced similar changes. Either may provide immediate- or short-term change; no long-term data are available. Thoracic manipulation may improve pain and function. Optimal techniques and dose are unresolved. Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.

[1]  G. Jull,et al.  Cervical mobilisation: concurrent effects on pain, sympathetic nervous system activity and motor activity. , 2001, Manual therapy.

[2]  J. Ahlberg,et al.  Active or passive treatment for neck-shoulder pain in occupational health care? A randomized controlled trial. , 2004, Occupational medicine.

[3]  Leslie J. Crofford,et al.  Primer on the Rheumatic Diseases , 1999 .

[4]  C. Goldsmith,et al.  A Cochrane Review of Manipulation and Mobilization for Mechanical Neck Disorders , 2004, Spine.

[5]  C. Goldsmith,et al.  Chiropractic manipulation in Adolescent Idiopathic Scoliosis: a pilot study , 2006, Chiropractic & osteopathy.

[6]  G. Allison,et al.  A randomized clinical trial of manual therapy for cervico-brachial pain syndrome -- a pilot study. , 2002, Manual therapy.

[7]  J. Miangolarra-Page,et al.  Manipulative Treatment vs. Conventional Physiotherapy Treatment in Whiplash Injury , 2004 .

[8]  G. Bove,et al.  [Therapeutic manipulation of episodic tension type headache. A randomized, controlled clinical trial]. , 2000, Ugeskrift for laeger.

[9]  Anita Gross,et al.  Manual therapy and exercise for neck pain: a systematic review. , 2010, Manual therapy.

[10]  Jari Ylinen,et al.  Active neck muscle training in the treatment of chronic neck pain in women: a randomized controlled trial. , 2003, JAMA.

[11]  V. Pfaffenrath,et al.  Cervicogenic Headache: Diagnostic Criteria , 1990, Headache.

[12]  J J Anderson,et al.  American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. , 1995, Arthritis and rheumatism.

[13]  C. Goldsmith,et al.  Manual therapy for mechanical neck disorders: a systematic review. , 2002, Manual therapy.

[14]  P. Côté,et al.  The Saskatchewan Health and Back Pain Survey: The Prevalence of Neck Pain and Related Disability in Saskatchewan Adults , 1998, Spine.

[15]  P. Beattie Measurement of health outcomes in the clinical setting: applications to physiotherapy , 2001 .

[16]  R. Nordemar,et al.  Treatment of acute cervical pain — A comparative group study , 1981, PAIN.

[17]  R. Fisher The Advanced Theory of Statistics , 1943, Nature.

[18]  N. Nilsson A randomized controlled trial of the effect of spinal manipulation in the treatment of cervicogenic headache. , 1995, Journal of manipulative and physiological therapeutics.

[19]  J. Dornan,et al.  The role of physiotherapy in the management of acute neck sprains following road-traffic accidents. , 1989, Archives of emergency medicine.

[20]  J. Cleland,et al.  Thoracic spine manipulation for the management of patients with neck pain: a randomized clinical trial. , 2009, The Journal of orthopaedic and sports physical therapy.

[21]  L. Bouter,et al.  Comparison of the effectiveness of a behavioural graded activity program and manual therapy in patients with sub-acute neck pain: design of a randomized clinical trial. , 2006, Manual therapy.

[22]  J. Cleland,et al.  Immediate effects of atlanto-occipital joint manipulation on active mouth opening and pressure pain sensitivity in women with mechanical neck pain. , 2009, Journal of manipulative and physiological therapeutics.

[23]  General Principles of Pain Management , 2008 .

[24]  L. Bouter,et al.  Manual Therapy, Physical Therapy, or Continued Care by the General Practitioner for Patients With Neck Pain: Long-Term Results From a Pragmatic Randomized Clinical Trial , 2006, The Clinical journal of pain.

[25]  M. Kendall,et al.  The advanced theory of statistics , 1945 .

[26]  Roongtiwa Vachalathiti,et al.  The immediate effects of mobilization technique on pain and range of motion in patients presenting with unilateral neck pain: a randomized controlled trial. , 2009, Archives of physical medicine and rehabilitation.

[27]  R. Muller,et al.  Long-term follow-up of a randomized clinical trial assessing the efficacy of medication, acupuncture, and spinal manipulation for chronic mechanical spinal pain syndromes. , 2005, Journal of manipulative and physiological therapeutics.

[28]  J. Kenardy,et al.  Does the presence of sensory hypersensitivity influence outcomes of physical rehabilitation for chronic whiplash? – A preliminary RCT , 2007, Pain.

[29]  C. Gustavsson,et al.  Applied relaxation in the treatment of long-lasting neck pain: a randomized controlled pilot study. , 2006, Journal of rehabilitation medicine.

[30]  P. Whincup,et al.  Randomised clinical trial of manipulative therapy and physiotherapy for persistent back and neck complaints: results of one year follow up. , 1992, BMJ.

[31]  J. Cleland,et al.  Changes in pressure pain thresholds over C5-C6 zygapophyseal joint after a cervicothoracic junction manipulation in healthy subjects. , 2008, Journal of manipulative and physiological therapeutics.

[32]  C. Wilkinson,et al.  Randomized osteopathic manipulation study (ROMANS): pragmatic trial for spinal pain in primary care. , 2003, Family practice.

[33]  G. Fryer,et al.  The effect of manual pressure release on myofascial trigger points in the upper trapezius muscle , 2005 .

[34]  H. Gemmell,et al.  Comparative effectiveness of manipulation, mobilisation and the Activator instrument in treatment of non-specific neck pain: a systematic review , 2006, Chiropractic & Osteopathy.

[35]  M. Nordin,et al.  The Burden and Determinants of Neck Pain in the General Population: Results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders , 2008, Spine.

[36]  C. Doré,et al.  Manipulation for Chronic Neck Pain: A Double‐Blind Controlled Study , 1982, Spine.

[37]  Richard G. Strunk,et al.  A feasibility study assessing manual therapies to different regions of the spine for patients with subacute or chronic neck pain. , 2008, Journal of chiropractic medicine.

[38]  C. Goldsmith,et al.  A Randomized Clinical Trial of Exercise and Spinal Manipulation for Patients With Chronic Neck Pain , 2001, Spine.

[39]  H. Vernon,et al.  The outcome of control groups in clinical trials of conservative treatments for chronic mechanical neck pain: a systematic review , 2006, BMC musculoskeletal disorders.

[40]  J. Cassidy,et al.  The immediate effect of manipulation versus mobilization on pain and range of motion in the cervical spine: a randomized controlled trial. , 1992, Journal of manipulative and physiological therapeutics.

[41]  R. D. de Bie,et al.  Conservative treatment for whiplash. , 2001, The Cochrane database of systematic reviews.

[42]  John D. Childs,et al.  Immediate Effects of Thoracic Manipulation in Patients with Neck Pain: A Randomized Clinical Trial , 2005, Manual therapy.

[43]  H. Morgenstern,et al.  Frequency and Clinical Predictors of Adverse Reactions to Chiropractic Care in the UCLA Neck Pain Study , 2005, Spine.

[44]  J. Krauss,et al.  The Immediate Effects of Upper Thoracic Translatoric Spinal Manipulation on Cervical Pain and Range of Motion: A Randomized Clinical Trial , 2008, The Journal of manual & manipulative therapy.

[45]  Chen Li,et al.  [Comparative study on effects of manipulation treatment and transcutaneous electrical nerve stimulation on patients with cervicogenic headache]. , 2007, Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.

[46]  A. Marques,et al.  Effect of Global Posture Reeducation and of Static Stretching on Pain, Range of Motion, and Quality of Life in Women with Chronic Neck Pain: A Randomized Clinical Trial , 2008, Clinics.

[47]  K. Jobst,et al.  Standards for reporting interventions in controlled trials of acupuncture: the STRICTA recommendations. , 2001, Complementary therapies in medicine.

[48]  B. Vicenzino,et al.  Neurophysiological effect of spinal manual therapy , 2004 .

[49]  Dwayne Van Eerd,et al.  The Prevalence and Incidence of Work Absenteeism Involving Neck Pain: A Cohort of Ontario Lost-Time Claimants , 2008, Spine.

[50]  S. Linton,et al.  A cognitive-behavioral group intervention as prevention for persistent neck and back pain in a non-patient population: a randomized controlled trial , 2001, Pain.

[51]  E. Skargren,et al.  Cost and Effectiveness Analysis of Chiropractic and Physiotherapy Treatment for Low Back and Neck Pain: Six‐Month Follow‐Up , 1997, Spine.

[52]  S. Johansson,et al.  Subacute and chronic, non-specific back and neck pain: cognitive-behavioural rehabilitation versus primary care. A randomized controlled trial , 2008, BMC musculoskeletal disorders.

[53]  L. Bouter,et al.  Complications of spinal manipulation: a comprehensive review of the literature. , 1996, The Journal of family practice.

[54]  Jennifer M Muggleton,et al.  An objective spinal motion imaging assessment (OSMIA): reliability, accuracy and exposure data , 2006, BMC musculoskeletal disorders.

[55]  C. Carlsson,et al.  Long-Lasting Cervical Radicular Pain Managed With Surgery, Physiotherapy, or a Cervical Collar: A Prospective, Randomized Study , 1997, Spine.

[56]  J. David,et al.  Chronic neck pain: a comparison of acupuncture treatment and physiotherapy. , 1998, British journal of rheumatology.

[57]  Hong Wang,et al.  [Effect of vertebral manipulation therapy on vertebro-basilar artery blood flow in cervical spondylosis of vertebral artery type]. , 2005, Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.

[58]  D. Moher,et al.  The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration , 2001, Annals of Internal Medicine.

[59]  John D. Childs,et al.  Development of a Clinical Prediction Rule for Guiding Treatment of a Subgroup of Patients With Neck Pain: Use of Thoracic Spine Manipulation, Exercise, and Patient Education , 2007, Physical Therapy.

[60]  A. Verhagen,et al.  Randomized clinical trial of conservative treatment for patients with whiplash-associated disorders: considerations for the design and dynamic treatment protocol. , 2003, Journal of manipulative and physiological therapeutics.

[61]  M. O. Egwu Relative Therapeutic Efficacy of Some Vertebral Mobilization Techniques in the Management of Unilateral Cervical Spondylosis: A Comparative Study , 2008 .

[62]  Olavi Airaksinen,et al.  Effectiveness of traditional bone setting in chronic neck pain: randomized clinical trial. , 2007, Journal of manipulative and physiological therapeutics.

[63]  G. Méal A clinical trial investigating the possible effect of the supine cervical rotary manipulation and the supine rotary break manipulation in the treatment of mechanical neck pain: a pilot study. , 2000, Journal of manipulative and physiological therapeutics.

[64]  W. Dupont,et al.  Power and sample size calculations. A review and computer program. , 1990, Controlled clinical trials.

[65]  M. Coppieters,et al.  The immediate effects of a cervical lateral glide treatment technique in patients with neurogenic cervicobrachial pain. , 2003, The Journal of orthopaedic and sports physical therapy.

[66]  T. Bendix,et al.  Intensive Training, Physiotherapy, or Manipulation for Patients With Chronic Neck Pain: A Prospective, Single‐Blinded, Randomized Clinical Trial , 1998, Spine.

[67]  Lex M Bouter,et al.  Cost-of-illness of neck pain in The Netherlands in 1996 , 1999, Pain.

[68]  赵红彬 Placebo , 2007 .

[69]  D. Rubin,et al.  Statistical Analysis with Missing Data. , 1989 .

[70]  R. D. de Bie,et al.  Conservative treatments for whiplash. , 2007, The Cochrane database of systematic reviews.

[71]  H. Vernon,et al.  Pressure pain threshold evaluation of the effect of spinal manipulation in the treatment of chronic neck pain: a pilot study. , 1990, Journal of manipulative and physiological therapeutics.

[72]  J. Pool,et al.  A systematic review of the diagnostic accuracy of provocative tests of the neck for diagnosing cervical radiculopathy , 2007, European Spine Journal.

[73]  Andrea Furlan,et al.  Updated Method Guidelines for Systematic Reviews in the Cochrane Collaboration Back Review Group , 2003, Spine.

[74]  M. Aickin,et al.  Dose response for chiropractic care of chronic cervicogenic headache and associated neck pain: a randomized pilot study. , 2004, Journal of manipulative and physiological therapeutics.

[75]  J. Cleland,et al.  Does Continuing Education Improve Physical Therapists’ Effectiveness in Treating Neck Pain? A Randomized Clinical Trial , 2009, Physical Therapy.

[76]  Mitchell Haas,et al.  Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis. , 2004, The spine journal : official journal of the North American Spine Society.

[77]  L. Hurley,et al.  Clinical practice guideline on the use of manipulation or mobilization in the treatment of adults with mechanical neck disorders. , 2002, Manual therapy.

[78]  S J Linton,et al.  A Population‐Based Study of Spinal Pain Among 35‐45‐Year‐Old Individuals: Prevalence, Sick Leave, and Health Care Use , 1998, Spine.

[79]  J. Brantingham,et al.  The relative effectiveness of spinal manipulation and ultrasound in mechanical pain: Pilot study. , 2002, Journal of chiropractic medicine.

[80]  R. Schenk,et al.  The Effects of Muscle Energy Technique on Cervical Range of Motion , 1994 .

[81]  C. Goldsmith,et al.  Two-Year Follow-up of a Randomized Clinical Trial of Spinal Manipulation and Two Types of Exercise for Patients with Chronic Neck Pain , 2002, Spine.

[82]  H. Pollard,et al.  A randomized controlled trial of chiropractic spinal manipulative therapy for migraine. , 2000, Journal of manipulative and physiological therapeutics.

[83]  S. Metcalfe,et al.  Effect of High-Velocity Low-Amplitude Manipulation on Cervical Spine Muscle Strength: A Randomized Clinical Trial , 2006 .

[84]  M. Nordin,et al.  A New Conceptual Model of Neck Pain: Linking Onset, Course, and Care: The Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders , 2008, Spine.

[85]  Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. , 1988, Cephalalgia : an international journal of headache.

[86]  R. Muller,et al.  Chronic spinal pain syndromes: a clinical pilot trial comparing acupuncture, a nonsteroidal anti-inflammatory drug, and spinal manipulation. , 1999, Journal of manipulative and physiological therapeutics.

[87]  Mikel Aickin,et al.  Efficacy of Cervical Endplay Assessment as an Indicator for Spinal Manipulation , 2003, Spine.

[88]  P Tugwell,et al.  Criteria for clinically important changes in outcomes: development, scoring and evaluation of rheumatoid arthritis patient and trial profiles. OMERACT Committee. , 1993, The Journal of rheumatology.

[89]  G. Bronfort,et al.  A pilot study for a randomized clinical trial assessing chiropractic care, medical care, and self-care education for acute and subacute neck pain patients. , 2003, Journal of manipulative and physiological therapeutics.

[90]  C. Colloca,et al.  A pilot randomized clinical trial on the relative effect of instrumental (MFMA) versus manual (HVLA) manipulation in the treatment of cervical spine dysfunction. , 2001, Journal of manipulative and physiological therapeutics.

[91]  L. McKinney Early mobilisation and outcome in acute sprains of the neck. , 1989, BMJ.

[92]  Claire Bombardier,et al.  2009 Updated Method Guidelines for Systematic Reviews in the Cochrane Back Review Group , 2009, Spine.

[93]  T. Jensen,et al.  Neck Collar, “Act-as-Usual” or Active Mobilization for Whiplash Injury?: A Randomized Parallel-Group Trial , 2007, Spine.

[94]  P. Santaguida,et al.  Conservative management of mechanical neck disorders: a systematic review. , 2007, The Journal of rheumatology.

[95]  W. Spitzer,et al.  Scientific monograph of the Quebec Task Force on Whiplash-Associated Disorders: redefining "whiplash" and its management. , 1995, Spine.

[96]  N Nilsson,et al.  Active range of motion in the cervical spine increases after spinal manipulation (toggle recoil). , 2001, Journal of manipulative and physiological therapeutics.

[97]  N. Bogduk Whiplash: “Why Pay for What Does Not Work?” , 2000 .

[98]  H. Morgenstern,et al.  The impact of psychosocial factors on neck pain and disability outcomes among primary care patients: Results from the UCLA Neck Pain Study , 2006, Disability and rehabilitation.

[99]  E. Finch Physical rehabilitation outcome measures : a guide to enhanced clinical decision making , 2002 .

[100]  William D. Dupont,et al.  Power and sample size calculations. A review and computer program. , 1990, Controlled clinical trials.

[101]  L. Persson,et al.  Pain, coping, emotional state and physical function in patients with chronic radicular neck pain. A comparison between patients treated with surgery, physiotherapy or neck collar--a blinded, prospective randomized study. , 2001, Disability and rehabilitation.

[102]  U. Moritz,et al.  Cervical radiculopathy: Pain, muscle weakness and sensory loss in patients with cervical radiculopathy treated with surgery, physiotherapy or cervical collar A prospective, controlled study , 2005, European Spine Journal.

[103]  E. Skargren,et al.  Predictive factors for 1-year outcome of low-back and neck pain in patients treated in primary care: comparison between the treatment strategies chiropractic and physiotherapy , 1998, Pain.

[104]  K. Jobst,et al.  Standards for Reporting Interventions in Controlled Trials of Acupuncture: The Stricta Recommendations , 2002, Journal of alternative and complementary medicine.

[105]  R. D. de Bie,et al.  The Efficacy of Conservative Treatment in Patients With Whiplash Injury: A Systematic Review of Clinical Trials , 2001, Spine.

[106]  P. Huijbregts,et al.  Immediate Effects of Inhibitive Distraction on Active Range of Cervical Flexion in Patients with Neck Pain: A Pilot Study , 2007, The Journal of manual & manipulative therapy.

[107]  J. Farrar,et al.  Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale , 2001, PAIN.

[108]  J. Hartvigsen,et al.  Lasting changes in passive range motion after spinal manipulation: a randomized, blind, controlled trial. , 1996, Journal of manipulative and physiological therapeutics.

[109]  F. F. Nielsen,et al.  An Open Study Comparing Manual Therapy with the Use of Cold Packs in the Treatment of Post-Traumatic Headache , 1990, Cephalalgia : an international journal of headache.

[110]  Danny R. Miller,et al.  AND ITS MANAGEMENT , 1973 .

[111]  C. Goldsmith,et al.  Measurement properties of the neck disability index: a systematic review. , 2009, The Journal of orthopaedic and sports physical therapy.

[112]  Nicole A. Lazar,et al.  Statistical Analysis With Missing Data , 2003, Technometrics.

[113]  H. Morgenstern,et al.  A randomized trial of chiropractic manipulation and mobilization for patients with neck pain: clinical outcomes from the UCLA neck-pain study. , 2002, American journal of public health.

[114]  L. Bouter,et al.  Manual Therapy, Physical Therapy, or Continued Care by a General Practitioner for Patients with Neck Pain , 2002, Annals of Internal Medicine.

[115]  A. Nürnberger,et al.  Osteopathic Treatment of Patients with Chronic Non-Specific Neck Pain: A Randomised Controlled Trial of Efficacy , 2008, Complementary Medicine Research.

[116]  E. Skargren,et al.  One‐Year Follow‐up Comparison of the Cost and Effectiveness of Chiropractic and Physiotherapy as Primary Management for Back Pain: Subgroup Analysis, Recurrence, and Additional Health Care Utilization , 1998, Spine.

[117]  Per J Palmgren,et al.  Improvement after chiropractic care in cervicocephalic kinesthetic sensibility and subjective pain intensity in patients with nontraumatic chronic neck pain. , 2006, Journal of manipulative and physiological therapeutics.

[118]  M. Simmonds,et al.  Self-reports and clinician-measured physical function among patients with low back pain: a comparison. , 2001, Archives of physical medicine and rehabilitation.

[119]  Jeffrey D. Boyling,et al.  Grieve's Modern Manual Therapy: The Vertebral Column , 1994 .

[120]  J. Miangolarra-Page,et al.  Dorsal Manipulation in Whiplash Injury Treatment: A Randomized Controlled Trial , 2004 .

[121]  C. Goldsmith,et al.  Manipulation and mobilisation for mechanical neck disorders. , 2004, The Cochrane database of systematic reviews.

[122]  H. Vernon,et al.  Chronic mechanical neck pain in adults treated by manual therapy: a systematic review of change scores in randomized clinical trials. , 2007, Journal of manipulative and physiological therapeutics.

[123]  H. Brodin Cervical pain and mobilization , 1983, Acta Belgica. Medica physica : organe officiel de la Societe royale belge de medecine physique et de rehabilitation.

[124]  H. Hemmilä,et al.  Bone setting for prolonged neck pain: a randomized clinical trial. , 2005, Journal of manipulative and physiological therapeutics.

[125]  Lex M Bouter,et al.  The clinical course and prognostic factors of non-specific neck pain: a systematic review , 1998, Pain.

[126]  Scott Haldeman,et al.  Treatment of Neck Pain: Noninvasive Interventions: Results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders , 2008, Spine.

[127]  A. Häkkinen,et al.  Effect of manual therapy and stretching on neck muscle strength and mobility in chronic neck pain. , 2007, Journal of rehabilitation medicine.

[128]  G. Fénelon,et al.  Early mobilization of acute whiplash injuries. , 1986, British medical journal.

[129]  K. Søballe,et al.  Effectiveness of accelerated perioperative care and rehabilitation intervention compared to current intervention after hip and knee arthroplasty. A before-after trial of 247 patients with a 3-month follow-up , 2008, BMC musculoskeletal disorders.

[130]  L. Bouter,et al.  A Critical Appraisal of Review Articles on the Effectiveness of Conservative Treatment for Neck Pain , 2001, Spine.

[131]  L. Bouter,et al.  The Effectiveness of Manual Therapy, Physiotherapy, and Treatment by the General Practitioner for Nonspecific Back and Neck Complaints: A Randomized Clinical Trial , 1992, Spine.

[132]  A. Agur,et al.  Mobilizations of the asymptomatic cervical spine can reduce signs of shoulder dysfunction in adults. , 2009, Manual therapy.

[133]  R. Ferrari,et al.  Prospective, Randomized, Controlled Study of Activity versus Collar, and the Natural History for Whiplash Injury, in Germany , 2000 .

[134]  U. Moritz,et al.  Postural and symptomatic improvement after physiotherapy in patients with dizziness of suspected cervical origin. , 1996, Archives of physical medicine and rehabilitation.

[135]  J. Dumville,et al.  Randomized trial of two physiotherapy interventions for primary care back and neck pain patients: cost effectiveness analysis. , 2007, Rheumatology.

[136]  D V Cicchetti,et al.  Assessing Inter-Rater Reliability for Rating Scales: Resolving some Basic Issues , 1976, British Journal of Psychiatry.

[137]  C. Fernández‐de‐las‐Peñas,et al.  Immediate effects on neck pain and active range of motion after a single cervical high-velocity low-amplitude manipulation in subjects presenting with mechanical neck pain: a randomized controlled trial. , 2006, Journal of manipulative and physiological therapeutics.

[138]  J. Hartvigsen,et al.  The effect of spinal manipulation in the treatment of cervicogenic headache. , 1997, Journal of manipulative and physiological therapeutics.

[139]  C. Marsden,et al.  EMG biofeedback treatment of torticollis: A controlled outcome study , 1991, Biofeedback and self-regulation.

[140]  H. Vernon,et al.  A systematic review of conservative treatments for acute neck pain not due to whiplash. , 2005, Journal of manipulative and physiological therapeutics.

[141]  C. Greenwood,et al.  VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis , 2007, BMC musculoskeletal disorders.