The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.
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Rafał Kurczab | Mateusz Nowak | Ingebrigt Sylte | Andrzej J Bojarski | Zdzisław Chilmonczyk | I. Sylte | M. Nowak | A. Bojarski | Rafał Kurczab | Z. Chilmonczyk
[1] V. A. Davis,et al. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus , 2005, Brain Research.
[2] Alexandre Varnek,et al. Chemoinformatics approaches to virtual screening , 2008 .
[3] Ferran Sanz,et al. Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor. , 2007, Journal of medicinal chemistry.
[4] R. Jakus,et al. Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy , 2004, Neuroscience Letters.
[5] D. Sibley,et al. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. , 1993, The Journal of biological chemistry.
[6] G. Klebe,et al. Successful virtual screening for a submicromolar antagonist of the neurokinin-1 receptor based on a ligand-supported homology model. , 2004, Journal of medicinal chemistry.
[7] R. Eglen,et al. Characterization of putative 5‐ht7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein , 1996, British journal of pharmacology.
[8] Andreas Evers,et al. Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocols. , 2005, Journal of medicinal chemistry.
[9] M. Nowak,et al. Homology modeling of the serotonin 5-HT1A receptor using automated docking of bioactive compounds with defined geometry. , 2006, Journal of medicinal chemistry.
[10] Mateusz Nowak,et al. Receptor-based pharmacophores for serotonin 5-HT7R antagonists-implications to selectivity. , 2006, Journal of medicinal chemistry.
[11] H. Vaudry,et al. Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands. , 2005, Bioorganic & medicinal chemistry letters.
[12] M. Ikeda,et al. Positive Association of the Serotonin 5-HT7 Receptor Gene with Schizophrenia in a Japanese Population , 2006, Neuropsychopharmacology.
[13] A. Dogrul,et al. Systemic morphine produce antinociception mediated by spinal 5‐HT7, but not 5‐HT1A and 5‐HT2 receptors in the spinal cord , 2006, British journal of pharmacology.
[14] T. Branchek,et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. , 1993, The Journal of biological chemistry.
[15] E. Kellenberger,et al. Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening. , 2007, Journal of medicinal chemistry.
[16] J. Terrón,et al. Is the 5-HT(7) receptor involved in the pathogenesis and prophylactic treatment of migraine? , 2002, European journal of pharmacology.
[17] P. Hedlund. The 5-HT7 receptor and disorders of the nervous system: an overview , 2009, Psychopharmacology.
[18] G. Mcallister,et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor , 2003, Neuropharmacology.
[19] A. Meneses. Effects of the 5-HT7 receptor antagonists SB-269970 and DR 4004 in autoshaping Pavlovian/instrumental learning task , 2004, Behavioural Brain Research.
[20] H. van de Waterbeemd,et al. ADMET in silico modelling: towards prediction paradise? , 2003, Nature reviews. Drug discovery.
[21] P P Humphrey,et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). , 1994, Pharmacological reviews.