Regions of the MPFC differentially tuned to social and nonsocial affective evaluation

The medial prefrontal cortex (MPFC) reliably activates in social cognition and reward tasks. This study locates distinct areas for each. Participants made evaluative (positive/negative) or social (person/not a person) judgments of pictured positive or negative people and objects in a slow event-related design. Activity in an anterior rostral region (arMPFC) was significantly greater for positive than for negative persons but did not show a valence effect for objects, and this was true regardless of the judgment task. This suggests that the arMPFC is tuned to social valence. Interestingly, however, no regions of the MPFC were found to be responsive to social information independently of valence. A region-of-interest analysis of the paraanterior cingulate cortex (pACC), previously implicated in reward processing, demonstrated sensitivity to the valence of all stimuli, whether persons or objects, across tasks. Affective evaluation may be a general function of the MPFC, with some regions being tuned to more specific domains of information (e.g., social) than are others.

[1]  S. Inati,et al.  An fMRI study of reward-related probability learning , 2005, NeuroImage.

[2]  E. Rolls,et al.  Abstract reward and punishment representations in the human orbitofrontal cortex , 2001, Nature Neuroscience.

[3]  James K Rilling,et al.  The neural correlates of theory of mind within interpersonal interactions , 2004, NeuroImage.

[4]  Susan T. Fiske,et al.  Attention and weight in person perception: The impact of negative and extreme behavior. , 1980 .

[5]  Uta Frith,et al.  The Biological Basis of Social Interaction , 2001 .

[6]  C. Frith,et al.  Functional imaging of ‘theory of mind’ , 2003, Trends in Cognitive Sciences.

[7]  M. Bradley,et al.  Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. , 1994, Journal of behavior therapy and experimental psychiatry.

[8]  Jonathan D. Cohen,et al.  Imaging valuation models in human choice. , 2006, Annual review of neuroscience.

[9]  D. A. Kenny,et al.  Reconceptualizing individual differences in self-enhancement bias: an interpersonal approach. , 2004, Psychological review.

[10]  R. Passingham,et al.  Brain Mechanisms for Inferring Deceit in the Actions of Others , 2004, The Journal of Neuroscience.

[11]  C. Frith,et al.  Meeting of minds: the medial frontal cortex and social cognition , 2006, Nature Reviews Neuroscience.

[12]  Brian Knutson,et al.  A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI , 2003, NeuroImage.

[13]  L. A. McArthur.  The how and what of why: Some determinants and consequences of causal attribution. , 1972 .

[14]  A. Smit,et al.  Synapse Formation between Central Neurons Requires Postsynaptic Expression of the MEN1 Tumor Suppressor Gene , 2001, The Journal of Neuroscience.

[15]  G. Pagnoni,et al.  A Neural Basis for Social Cooperation , 2002, Neuron.

[16]  Clay B. Holroyd,et al.  Knowing good from bad: differential activation of human cortical areas by positive and negative outcomes , 2005, The European journal of neuroscience.

[17]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[18]  E. Wagenmakers,et al.  A Model-Averaging Approach to Replication : The Case of p rep , 2009 .

[19]  H. Kelley.  Attribution theory in social psychology , 1967 .

[20]  Vinod Goel,et al.  The Neural Basis of Conditional Reasoning with Arbitrary Content , 2004, Cortex.

[21]  Kevin N. Ochsner,et al.  The neural correlates of direct and reflected self-knowledge , 2005, NeuroImage.

[22]  Amy J. C. Cuddy,et al.  A model of (often mixed) stereotype content: competence and warmth respectively follow from perceived status and competition. , 2002, Journal of personality and social psychology.

[23]  Daniel Houser,et al.  A functional imaging study of cooperation in two-person reciprocal exchange , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[24]  C. Neil Macrae,et al.  The Link between Social Cognition and Self-referential Thought in the Medial Prefrontal Cortex , 2005, Journal of Cognitive Neuroscience.

[25]  Jonathan D. Cohen,et al.  An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. , 2005, Annual review of neuroscience.

[26]  D. O. Sears,et al.  The person-positivity bias. , 1983 .

[27]  Richard S. J. Frackowiak,et al.  Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension , 1995, Cognition.

[28]  Jonathan D. Cohen,et al.  The Neural Basis of Economic Decision-Making in the Ultimatum Game , 2003, Science.

[29]  Peter Dayan,et al.  A Neural Substrate of Prediction and Reward , 1997, Science.

[30]  R. Saxe,et al.  Making sense of another mind: The role of the right temporo-parietal junction , 2005, Neuropsychologia.

[31]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[32]  Samuel M. McClure,et al.  Dissociating affective evaluation and social cognitive processes in the ventral medial prefrontal cortex , 2007, Cognitive, affective & behavioral neuroscience.

[33]  Samuel M. McClure,et al.  Predictability Modulates Human Brain Response to Reward , 2001, The Journal of Neuroscience.

[34]  Alexander Todorov,et al.  Attributions on the brain: Neuro-imaging dispositional inferences, beyond theory of mind , 2005, NeuroImage.

[35]  Jason P. Mitchell,et al.  Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others , 2006, Neuron.

[36]  C. Frith,et al.  Movement and Mind: A Functional Imaging Study of Perception and Interpretation of Complex Intentional Movement Patterns , 2000, NeuroImage.

[37]  Brian Knutson,et al.  Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens , 2001, The Journal of Neuroscience.

[38]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[39]  Shelley E. Taylor,et al.  Illusion and well-being: a social psychological perspective on mental health. , 1988, Psychological bulletin.

[40]  S. Fiske,et al.  Dehumanizing the Lowest of the Low , 2006, Psychological science.

[41]  J. O'Doherty,et al.  Decoding the neural substrates of reward-related decision making with functional MRI , 2007, Proceedings of the National Academy of Sciences.

[42]  Samuel M. McClure,et al.  Separate Neural Systems Value Immediate and Delayed Monetary Rewards , 2004, Science.

[43]  Susan T. Fiske,et al.  The brooms in fantasia: Neural correlates of anthropomorphizing objects , 2008 .

[44]  Samuel M. McClure,et al.  Time Discounting for Primary Rewards , 2007, The Journal of Neuroscience.

[45]  R. E Passingham,et al.  Inferring false beliefs from the actions of oneself and others: an fMRI study , 2004, NeuroImage.

[46]  D. Perrett,et al.  Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness , 2003, Neuropsychologia.

[47]  Matthew T. Kaufman,et al.  Distributed Neural Representation of Expected Value , 2005, The Journal of Neuroscience.

[48]  Amy J. C. Cuddy,et al.  Universal dimensions of social cognition: warmth and competence , 2007, Trends in Cognitive Sciences.

[49]  C. Frith,et al.  The Neural Basis of Mentalizing , 2006, Neuron.

[50]  Jonathan D. Cohen,et al.  The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasks. , 2006, Psychological review.

[51]  Shelley E. Taylor,et al.  Social Cognition, from Brains to Culture , 1984 .

[52]  S. Carey,et al.  Understanding other minds: linking developmental psychology and functional neuroimaging. , 2004, Annual review of psychology.

[53]  P. Dayan,et al.  Cortical substrates for exploratory decisions in humans , 2006, Nature.