The formation of sensorimotor circuits

Recent studies have identified some of the key molecular pathways that control the genesis of spinal sensorimotor circuits. Transcription factors play a central role in these events, regulating both the specification of neurons that constitute these sensorimotor pathways and the expression of downstream molecules that control the wiring up of these neurons into topologically interconnected neuronal networks.

[1]  T. Jessell,et al.  Control of Interneuron Fate in the Developing Spinal Cord by the Progenitor Homeodomain Protein Dbx1 , 2001, Neuron.

[2]  M. Goulding,et al.  Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. , 1999, Development.

[3]  M. Goulding,et al.  Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. , 1993, Development.

[4]  David J. Anderson,et al.  The Paired Homeodomain Protein DRG11 Is Required for the Projection of Cutaneous Sensory Afferent Fibers to the Dorsal Spinal Cord , 2001, Neuron.

[5]  M. Bronner‐Fraser,et al.  Neural crest specification regulated by the helix-loop-helix repressor Id2. , 1998, Science.

[6]  T. Jessell,et al.  Different Levels of Repressor Activity Assign Redundant and Specific Roles to Nkx6 Genes in Motor Neuron and Interneuron Specification , 2001, Neuron.

[7]  Bernd Fritzsch,et al.  Proprioceptor Pathway Development Is Dependent on MATH1 , 2001, Neuron.

[8]  Michael J. O'Donovan,et al.  Topographical and physiological characterization of interneurons that express engrailed-1 in the embryonic chick spinal cord. , 2000, Journal of neurophysiology.

[9]  T. Jessell,et al.  A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube , 2000, Cell.

[10]  David J. Anderson,et al.  neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia , 1998, Neuron.

[11]  T. Jessell.  Neuronal specification in the spinal cord: inductive signals and transcriptional codes , 2000, Nature Reviews Genetics.

[12]  T. Jessell,et al.  Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord , 1991, Cell.

[13]  T. Jessell,et al.  Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2 , 2001, Neuron.

[14]  N. Kudo,et al.  N-Methyl-d,l-aspartate-induced locomotor activity in a spinal cord-indlimb muscles preparation of the newborn rat studied in vitro , 1987, Neuroscience Letters.

[15]  M. Bronner‐Fraser,et al.  Molecular mechanisms of neural crest formation. , 1999, Annual review of cell and developmental biology.

[16]  T. Jessell,et al.  A Role for the Roof Plate and Its Resident TGFβ-Related Proteins in Neuronal Patterning in the Dorsal Spinal Cord , 1997, Cell.

[17]  D G Wilkinson,et al.  Control of cell behavior during vertebrate development by Slug, a zinc finger gene. , 1994, Science.

[18]  M. Goulding,et al.  Evx1 Is a Postmitotic Determinant of V0 Interneuron Identity in the Spinal Cord , 2001, Neuron.

[19]  E. Frank,et al.  Formation of Specific Monosynaptic Connections between Muscle Spindle Afferents and Motoneurons in the Mouse , 1997, The Journal of Neuroscience.

[20]  A. Jarman,et al.  The specificity of proneural genes in determining Drosophila sense organ identity , 1998, Mechanisms of Development.

[21]  C. Sherrington.  Integrative Action of the Nervous System , 1907 .

[22]  F. Guillemot,et al.  The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons , 1998, Neuron.

[23]  David J. Anderson,et al.  The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification , 2002, Cell.

[24]  M. Tresch,et al.  Gap junctions and motor behavior , 2002, Trends in Neurosciences.

[25]  T. Jessell,et al.  Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm , 1995, Cell.

[26]  E. Turner,et al.  Defects in Sensory Axon Growth Precede Neuronal Death in Brn3a-Deficient Mice , 2001, The Journal of Neuroscience.

[27]  P. Brûlet,et al.  Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. , 1998, Development.

[28]  M. Goulding,et al.  Lbx1 Specifies Somatosensory Association Interneurons in the Dorsal Spinal Cord , 2002, Neuron.

[29]  M. Nakafuku,et al.  Combinatorial Roles of Olig2 and Neurogenin2 in the Coordinated Induction of Pan-Neuronal and Subtype-Specific Properties of Motoneurons , 2001, Neuron.

[30]  P. Ebert,et al.  Crossinhibitory Activities of Ngn1 and Math1 Allow Specification of Distinct Dorsal Interneurons , 2001, Neuron.

[31]  Tao Sun,et al.  Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection , 2002, Cell.

[32]  L. Landmesser,et al.  Cholinergic and GABAergic Inputs Drive Patterned Spontaneous Motoneuron Activity before Target Contact , 1999, The Journal of Neuroscience.

[33]  David J. Anderson,et al.  The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2 , 2001, Neuron.

[34]  T. Jessell,et al.  The Homeodomain Factor Lbx1 Distinguishes Two Major Programs of Neuronal Differentiation in the Dorsal Spinal Cord , 2002, Neuron.

[35]  K. Mizuseki,et al.  Requirement of FoxD3-class signaling for neural crest determination in Xenopus. , 2001, Development.

[36]  S. Shirasawa,et al.  Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. , 2002, Genes & development.

[37]  T. Jessell,et al.  Regulation of Motor Neuron Pool Sorting by Differential Expression of Type II Cadherins , 2002, Cell.

[38]  Silvia Arber,et al.  ETS Gene Er81 Controls the Formation of Functional Connections between Group Ia Sensory Afferents and Motor Neurons , 2000, Cell.

[39]  M. Goulding,et al.  The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate. , 2001, Development.