Naphthoquine: An Emerging Candidate for Artemisinin Combination Therapy

[1]  M. Fay,et al.  Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. , 2016, The Lancet. Infectious diseases.

[2]  Cho Naing,et al.  A systematic review of the efficacy of a single dose artemisinin–naphthoquine in treating uncomplicated malaria , 2015, Malaria Journal.

[3]  L. Cui,et al.  In Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparum , 2015, Antimicrobial Agents and Chemotherapy.

[4]  R. Price,et al.  Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax , 2015, Antimicrobial Agents and Chemotherapy.

[5]  P. Siba,et al.  Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: a six months post-treatment follow-up study , 2015, Malaria Journal.

[6]  G. Shanks,et al.  Evolution from double to triple-antimalarial drug combinations. , 2015, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[7]  R. Isba,et al.  Artemisinin‐naphthoquine for treating uncomplicated Plasmodium falciparum malaria , 2015, The Cochrane database of systematic reviews.

[8]  A. Rosanas-Urgell,et al.  Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea , 2015, Malaria Journal.

[9]  Stephan Karl,et al.  Artemisinin-Naphthoquine versus Artemether-Lumefantrine for Uncomplicated Malaria in Papua New Guinean Children: An Open-Label Randomized Trial , 2014, PLoS medicine.

[10]  O. Oduwole,et al.  Artemisinin-naphthoquine versus Artemether-lumefantrine for treating uncomplicated plasmodium falciparum malaria in children: A randomized controlled trial of efficacy and safety , 2014 .

[11]  Changhai Chen.  Development of antimalarial drugs and their application in China: a historical review , 2014, Infectious Diseases of Poverty.

[12]  Heng-lin Yang,et al.  Artemisinin-naphthoquine combination versus chloroquine-primaquine to treat vivax malaria: an open-label randomized and non-inferiority trial in Yunnan Province, China , 2013, Malaria Journal.

[13]  S. El-Beshbishi,et al.  First insight into the effect of single oral dose therapy with artemisinin-naphthoquine phosphate combination in a mouse model of Schistosoma mansoni infection. , 2013, International journal for parasitology.

[14]  O. Oduwole,et al.  Open-label trial of three dosage regimens of fixed-dose combination of artemisinin and naphthoquine for treating uncomplicated falciparum malaria in calabar, Nigeria , 2012, Malaria Journal.

[15]  K. Bojang,et al.  Malaria in infants aged less than six months - is it an area of unmet medical need? , 2012, Malaria Journal.

[16]  J. López-Abán,et al.  Systematic Review and Meta-Analysis of Artemisinin Based Therapies for the Treatment and Prevention of Schistosomiasis , 2012, PloS one.

[17]  E. Tjitra,et al.  Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia , 2012, Malaria Journal.

[18]  P. Siba,et al.  Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study , 2012, Antimicrobial Agents and Chemotherapy.

[19]  P. Siba,et al.  Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Tolerability, Safety, and Preliminary Efficacy Study , 2012, Antimicrobial Agents and Chemotherapy.

[20]  A. Massougbodji,et al.  [A randomized clinical trial comparing the effectiveness and tolerability of artemisinine-naphthoquine (Arco®) and artemether-lumefantrine (Coartem®) in the treatment of uncomplicated malaria in Benin]. , 2012, Bulletin de la Societe de pathologie exotique.

[21]  D. Kindé-Gazard,et al.  Essai clinique randomisé comparant l’efficacité et la tolérance de la combinaison artémisinine-naphthoquine (Arco®) et artéméther-luméfantrine (Coartem®) dans le traitement du paludisme simple au Bénin , 2012 .

[22]  E. Winzeler,et al.  The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites , 2012, PLoS medicine.

[23]  Kelly Chibale,et al.  The state of the art in anti-malarial drug discovery and development. , 2011, Current topics in medicinal chemistry.

[24]  W. Cao,et al.  Plasmodium berghei K173: selection of resistance to naphthoquine in a mouse model. , 2011, Experimental parasitology.

[25]  F. Hombhanje,et al.  Artemisinin-Naphthoquine Combination (ARCO®): An Overview of the Progress , 2010, Pharmaceuticals.

[26]  F. Muregi.  Antimalarial drugs and their useful therapeutic lives: rational drug design lessons from pleiotropic action of quinolines and artemisinins. , 2010, Current drug discovery technologies.

[27]  I. Mueller,et al.  Prevention and treatment of malaria in pregnancy. , 2010, Future microbiology.

[28]  Wei Liu,et al.  Single‐Dose Safety, Pharmacokinetics, and Food Effects Studies of Compound Naphthoquine Phosphate Tablets in Healthy Volunteers , 2010, Journal of clinical pharmacology.

[29]  P. Siba,et al.  In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea , 2010, Tropical medicine & international health : TM & IH.

[30]  S. Nsobya,et al.  A comparative study of Arco and Coartem in the treatment of uncomplicated malaria in patients aged 4 months to 16 years attending Mulago hospital, Kampala, Uganda , 2010 .

[31]  X. Su,et al.  Discovery, mechanisms of action and combination therapy of artemisinin , 2009, Expert review of anti-infective therapy.

[32]  Hlaing Tint,et al.  Efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. , 2009, Acta tropica.

[33]  A. Masta,et al.  Artemisinin-naphthoquine combination (ARCO™) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: A preliminary report on safety and efficacy , 2009, Malaria Journal.

[34]  L. Penali,et al.  A comparative, randomized clinical trial of artemisinin/naphtoquine twice daily one day versus artemether/lumefantrine six doses regimen in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire , 2009, Malaria Journal.

[35]  Jing-yan Wang,et al.  [Therapeutic efficacy of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi]. , 2008, Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases.

[36]  N. White.  Cardiotoxicity of antimalarial drugs. , 2007, The Lancet. Infectious diseases.

[37]  A. Glusker.  WHO confronts Chinese company over malaria drug , 2007, BMJ : British Medical Journal.

[38]  M. Tanner,et al.  Artemisinins for schistosomiasis and beyond. , 2007, Current opinion in investigational drugs.

[39]  T. Davis,et al.  Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs , 2006, Antimicrobial Agents and Chemotherapy.

[40]  J. Hamzah,et al.  In Vitro Interactions between Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs , 2006, Antimicrobial Agents and Chemotherapy.

[41]  R. Price,et al.  Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[42]  Wang Jingyan,et al.  Observation on efficacy of complex naphthoquine against Plasmodium vivax malaria , 2004 .

[43]  C. Shan,et al.  Naphthoquine phosphate and its combination with artemisinine. , 2004, Acta tropica.

[44]  F. Ou,et al.  [A randomized comparative study of naphtoquine, mefloquine and artsunate in the treatment of falciparum malaria]. , 2003, Zhonghua yi xue za zhi.

[45]  G. Brittenham,et al.  Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand. , 2003, The Southeast Asian journal of tropical medicine and public health.

[46]  P. Ringwald,et al.  In Vitro Activities of Piperaquine and Other 4-Aminoquinolines against Clinical Isolates of Plasmodium falciparum in Cameroon , 2003, Antimicrobial Agents and Chemotherapy.

[47]  D. Sullivan,et al.  On the molecular mechanism of chloroquine's antimalarial action. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[48]  T. Davis,et al.  In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. , 1996, International journal for parasitology.

[49]  S. El-Beshbishi,et al.  Spotlight on the in vitro effect of artemisinin-naphthoquine phosphate on Schistosoma mansoni and its snail host Biomphalaria alexandrina. , 2015, Acta tropica.

[50]  Onasanya Seun Sunday,et al.  THE ANTIMALARIA EFFECT OF DIFFERENT DOSAGE REGMEN OF ARTEMISININ-NAPHTHOQUINE ON PLASMODIUM BERGHEI INFECTED MICE , 2013 .

[51]  Wang Jian-hua.  Cost-minimization Analysis on 3 Kinds of Medicines in the Treatment of falciparum malaria , 2011 .

[52]  T. Wells.  New Medicines to Combat Malaria: An Overview of the Global Pipeline of Therapeutics , 2011 .

[53]  L. Hui,et al.  In vitro culture of naphthoquione-resistant Plasmodium falciparum strains in Yunnan Province. , 2010 .

[54]  Z. Zhiyong,et al.  Surveillance of Plasmodium falciparum susceptibility to seven antimalarials,including artemether,in the western part of the Sino-Myanmar border area , 2009 .

[55]  Zhang Zaixing.  Current Situation of Clinical Treatment of Falciparum Malaria in Yunnan , 2009 .

[56]  L. Hui,et al.  Treatment of malariae malaria with artesunate and naphthoquine phosphate: a report of two cases. , 2009 .

[57]  W. Jing.  STUDY OF SYNERGETIC EFFECT OF NAPHTHOQUINE PHOSPHATE AND ITS COMBINATION WITH ARTEMISININ AND ITS DELAYING EFFECT ON DRUG-RESISTANCE OF PLASMODIUM BERGHEI , 2008 .

[58]  Sha-Yen Cheng.  EFFICACY OF NAPHTHOQUINE PHOSPHATE,ARTEMISININE AND A COMBINATION OF THE TWO DRUG IN THE TREATMENT OF FALCIPARUM MALARIA , 2005 .

[59]  Yang Cang-jiang.  CURATIVE EFFECT ON ARTESUNATE-NAPHTHOQUINE COMBINATION IN TREATMENT OF MALARIA , 2004 .

[60]  Sha-Yen Cheng.  OBSERVATION ON EFFICACY OF COMPLEX NAPHTHOQUINE AGAINST PLASMODIUM VIVAX MALARIA , 2004 .

[61]  C. Shan,et al.  [Efficacy of naphthoquine, artemisinine and a combination of the two drugs in the treatment of falciparum malaria]. , 2003, Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases.

[62]  Lu Yun-fu.  CLINICAL TRIAL OF CO-NAPHTHOQUINE IN THE TREATMENT OF FALCIPARUM MALARIA , 2003 .

[63]  W. Jing.  Long-term toxicity of co-naphthoquine in beagle dogs , 2003 .

[64]  Li Li.  EFFICACY OF ARTESUNATE-NAPHTHOQUINE COMBINATION AGAINST FALCIPARUM MALARIA , 2003 .

[65]  Li Chun-fu.  Observation on the effectiveness of naphthoquine phosphate tablets on patients with vivax malaria and falciparum malaria. , 2003 .

[66]  Zhang Zhi-yong.  PREVENTIVE EFFECT ON NAPHTHOQUINE AGAINST VIVAX MALARIA AND DRUG RESISTANT FALCIPARUM MALARIA IN YUNNAN, CHINA , 2003 .

[67]  R. Snow,et al.  Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria , 2003 .

[68]  Y. Wen,et al.  [Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria]. , 2002, Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases.

[69]  W. Duo.  Observation on the effect of naphthoquine phosphate on the control of malaria in Qiongzhong County, Hainan Province , 2001 .

[70]  S. Jianping.  Dosage Verification of Compound Naphthoquine for Falciparum Malaria , 2001 .

[71]  G. Weizhong.  A Randomized_Controlled Study of Naphthoquine and Artesunate in the Treatment of Falciparum Malaria , 2000 .

[72]  Gerard Dumancas,et al.  [Data interpretation]. , 2000, Rinsho byori. The Japanese journal of clinical pathology.

[73]  Y. Jie.  Effect of Compound Naphthoquine on the Ultrastructure of Plasmodium berghei ANKA Strain in Erythrocytic Stage , 2000 .

[74]  Shao Ping,et al.  The effect of naphthoquine phosphate on the DNA content of Plasmodium yoelii yoelii: an analysis by flow cytometry. , 2000 .

[75]  D. Rong.  RECENT PROGRESS IN RESEARCH ON ANTIMALARIALS IN CHINA , 1989 .

[76]  J. D. Yang,et al.  [Studies on antimalarials synthesis of 4-arylamino-tert-butylaminomethyl phenols (author's transl)]. , 1982, Yao xue xue bao = Acta pharmaceutica Sinica.