论文信息 - RNAcentral 2021: secondary structure integration, improved sequence search and new member databases - 字舞流文

RNAcentral 2021: secondary structure integration, improved sequence search and new member databases

Abstract RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world’s largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org.

Robert D. Finn | Alex Bateman | Artemis G. Hatzigeorgiou | Jan Gorodkin | Zasha Weinberg | Shuai Weng | Jamie J. Cannone | Robin Ray Gutell | David Hoksza | Sam Griffiths-Jones | Jonathan M. Mudge | Sridhar Ramachandran | Eric P. Nawrocki | Wojciech M. Karlowski | Michelle S. Scott | Steven J. Marygold | Dimitra Karagkouni | Simona Panni | Pieter-Jan Volders | Anton I. Petrov | Simon Kay | Patricia P. Chan | Todd M. Lowe | Simon Fishilevich | Ruth C. Lovering | Stefan E. Seemann | Elspeth A. Bruford | Pablo Porras | Adam Frankish | Ioanna Kalvari | Pieter Mestdagh | Bastian Fromm | Ruth L. Seal | Lina Ma | Barbara Kramarz | Prita Mani | Blake A. Sweeney | Gilberto dos Santos | Maciej Szymanski | Ruth Barshir | Anton S. Petrov | Zhang Zhang | Lauren M. Lui | Carlos Eduardo Ribas | Kevin J. Peterson | Philia Bouchard-Bourelle | A. Frankish | R. Gutell | J. Gorodkin | R. Finn | A. Bateman | T. Lowe | A. Hatzigeorgiou | R. Lovering | S. Griffiths-Jones | S. Weng | J. Cannone | E. Bruford | S. Seemann | P. Porras | Z. Weinberg | S. Ramachandran | W. Karłowski | G. D. Santos | B. Kramarz | K. Peterson | Simon Fishilevich | Zhang Zhang | B. Sweeney | B. Fromm | P. Mestdagh | A. Petrov | Ruth Barshir | P. Volders | P. Mani | D. Hoksza | Lina Ma | Philia Bouchard-Bourelle | M. Szymanski | S. Panni | Simon Kay | Ioanna Kalvari | P. Chan | L. Lui | D. Karagkouni | C. E. Ribas | Bastian Fromm | C. Ribas | Prita Mani | Robin Gutell

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