The Binding Avidity of a Nanoparticle-based Multivalent Targeted Drug Delivery Platform

[1]  Rudy M. Baum,et al.  The Chemistry Of Biology , 2008 .

[2]  Seungpyo Hong,et al.  Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. , 2006, Bioconjugate chemistry.

[3]  Jason E Gestwicki,et al.  Synthetic multivalent ligands as probes of signal transduction. , 2006, Angewandte Chemie.

[4]  Philip S Low,et al.  Folate receptor-mediated drug targeting: from therapeutics to diagnostics. , 2005, Journal of pharmaceutical sciences.

[5]  D. Jaillard,et al.  Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments. , 2005, Bioconjugate chemistry.

[6]  Peter H. Seeberger,et al.  Automated synthesis of oligosaccharides as a basis for drug discovery , 2005, Nature Reviews Drug Discovery.

[7]  Thommey P. Thomas,et al.  Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy. , 2005, Journal of medicinal chemistry.

[8]  I. Majoros,et al.  HPLC analysis of PAMAM dendrimer based multifunctional devices. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[9]  Lennart Björck,et al.  Affinity and rate constants for interactions of bovine folate-binding protein and folate derivatives determined by optical biosensor technology. Effect of stereoselectivity. , 2005, Journal of agricultural and food chemistry.

[10]  Thommey P. Thomas,et al.  Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. , 2005, Cancer research.

[11]  Thommey P. Thomas,et al.  Targeting and inhibition of cell growth by an engineered dendritic nanodevice. , 2005, Journal of medicinal chemistry.

[12]  Thommey P. Thomas,et al.  Synthesis and functional evaluation of DNA-assembled polyamidoamine dendrimer clusters for cancer cell-specific targeting. , 2005, Chemistry & biology.

[13]  Thommey P. Thomas,et al.  In vitro targeting of synthesized antibody-conjugated dendrimer nanoparticles. , 2004, Biomacromolecules.

[14]  Alessandra Semenzato,et al.  Specific antitumor targetable beta-cyclodextrin-poly(ethylene glycol)-folic acid drug delivery bioconjugate. , 2004, Bioconjugate chemistry.

[15]  Ruth Duncan,et al.  Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation , 2004, Nature Biotechnology.

[16]  Seungpyo Hong,et al.  Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. , 2004, Bioconjugate chemistry.

[17]  B. Orr,et al.  Deformability of poly(amidoamine) dendrimers , 2004, The European physical journal. E, Soft matter.

[18]  J. Reddy,et al.  Folate-targeted chemotherapy. , 2004, Advanced drug delivery reviews.

[19]  D. Kranz,et al.  Folate-mediated targeting of T cells to tumors. , 2004, Advanced drug delivery reviews.

[20]  Thommey P. Thomas,et al.  Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor , 2002, Pharmaceutical Research.

[21]  Yuan-chuan Lee,et al.  Affinity enhancement by multivalent lectin–carbohydrate interaction , 2000, Glycoconjugate Journal.

[22]  P. Low,et al.  Folate receptor-mediated targeting of liposomal drugs to cancer cells. , 2004, Methods in enzymology.

[23]  P. Kitov,et al.  On the nature of the multivalency effect: a thermodynamic model. , 2003, Journal of the American Chemical Society.

[24]  I. Majoros,et al.  Acetylation of Poly(amidoamine) Dendrimers , 2003 .

[25]  David M. Gooden,et al.  Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction. , 2003, Journal of the American Chemical Society.

[26]  Ravi S Kane,et al.  Using bifunctional polymers presenting vancomycin and fluorescein groups to direct anti-fluorescein antibodies to self-assembled monolayers presenting d-alanine-d-alanine groups. , 2003, Journal of the American Chemical Society.

[27]  Philip S Low,et al.  Folate-mediated delivery of macromolecular anticancer therapeutic agents. , 2002, Advanced drug delivery reviews.

[28]  Anil K Patri,et al.  Dendritic polymer macromolecular carriers for drug delivery. , 2002, Current opinion in chemical biology.

[29]  R. M. Owen,et al.  Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. , 2002, Analytical biochemistry.

[30]  George M. Whitesides,et al.  Designing a polyvalent inhibitor of anthrax toxin , 2001, Nature Biotechnology.

[31]  P. Couvreur,et al.  Design of folic acid-conjugated nanoparticles for drug targeting. , 2000, Journal of pharmaceutical sciences.

[32]  J. Holm,et al.  High-affinity folate receptor in human ovary, serous ovarian adenocarcinoma, and ascites: radioligand binding mechanism, molecular size, ionic properties, hydrophobic domain, and immunoreactivity. , 1999, Archives of biochemistry and biophysics.

[33]  J. Baker,et al.  Inhibition of viral adhesion and infection by sialic-acid-conjugated dendritic polymers. , 1999, Bioconjugate chemistry.

[34]  George M Whitesides,et al.  Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors. , 1998, Angewandte Chemie.

[35]  G M Whitesides,et al.  A trivalent system from vancomycin.D-ala-D-Ala with higher affinity than avidin.biotin. , 1998, Science.

[36]  G. Whitesides,et al.  A trivalent system from vancomycin center dot D-Ala-D-Ala with higher affinity than avidin center dot biotin , 1998 .

[37]  M. Spinella,et al.  Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Yuan-chuan Lee,et al.  Carbohydrate-Protein Interactions: Basis of Glycobiology , 1995 .

[39]  J. Ross,et al.  Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications , 1994, Cancer.

[40]  P. Low,et al.  Selective targeting of malignant cells with cytotoxin-folate conjugates. , 1994, Journal of drug targeting.

[41]  R W Glaser,et al.  Antigen-antibody binding and mass transport by convection and diffusion to a surface: a two-dimensional computer model of binding and dissociation kinetics. , 1993, Analytical biochemistry.

[42]  V. Zurawski,et al.  Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis. , 1992, Cancer research.

[43]  L R Coney,et al.  Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. , 1992, Cancer research.

[44]  W. Foulkes,et al.  Folate-binding protein is a marker for ovarian cancer. , 1991, Cancer research.

[45]  P. Elwood,et al.  Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells. , 1988, The Journal of clinical investigation.