A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 7

[1]  Ming-Rong Zhang,et al.  Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain , 2020, bioRxiv.

[2]  Ana Martínez,et al.  Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition , 2018, Alzheimer's Research & Therapy.

[3]  Ana Martínez,et al.  Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo , 2017, Stem cells.

[4]  S. Dedeurwaerdere,et al.  Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging. , 2015, Nuclear medicine and biology.

[5]  Norbert Schuff,et al.  Bayesian segmentation of brainstem structures in MRI , 2015, NeuroImage.

[6]  F. Faucz,et al.  Clinical and molecular genetics of the phosphodiesterases (PDEs). , 2014, Endocrine reviews.

[7]  M. P. Kelly,et al.  Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. , 2014, Cellular signalling.

[8]  Arno Klein,et al.  101 Labeled Brain Images and a Consistent Human Cortical Labeling Protocol , 2012, Front. Neurosci..

[9]  C. Lugnier,et al.  Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments , 2012, British journal of pharmacology.

[10]  E. Karran,et al.  Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues , 2010, Neuropharmacology.

[11]  J. Beavo,et al.  Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use , 2006, Pharmacological Reviews.

[12]  G. Mengod,et al.  Neuronal expression of cAMP-specific phosphodiesterase 7B mRNA in the rat brain , 2005, Neuroscience.

[13]  Jeih-San Liow,et al.  Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  Robert B. Innis,et al.  Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  A. Dale,et al.  Whole Brain Segmentation Automated Labeling of Neuroanatomical Structures in the Human Brain , 2002, Neuron.

[16]  J. Palacios,et al.  Differential distribution of cAMP‐specific phosphodiesterase 7A mRNA in rat brain and peripheral organs , 2001, Synapse.

[17]  Robert B. Innis,et al.  Kinetic and equilibrium analyses of [123I]epidepride binding to striatal and extrastriatal dopamine D2 receptors , 1999 .

[18]  David J. Schlyer,et al.  Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  M. Phelps,et al.  Effects of Temporal Sampling, Glucose Metabolic Rates, and Disruptions of the Blood—Brain Barrier on the FDG Model with and without a Vascular Compartment: Studies in Human Brain Tumors with PET , 1986, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[20]  H. Akaike.  A new look at the statistical model identification , 1974 .

[21]  R. Ciccocioppo,et al.  Emerging targets for addiction neuropharmacology: From mechanisms to therapeutics. , 2016, Progress in brain research.

[22]  J. Morales-García,et al.  Tissue-Specific Progenitor and Stem Cells Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats , 2015 .