c‐erbB‐2 proto‐oncogene expression and its relationship to survival in gastric carcinoma: An immunohistochemical study on archival material

The c‐erbB‐2 proto‐oncogene encodes a growth factor receptor which is over‐expressed in a variety of human adenocarcinomas. Recent reports suggest that it may be of value in arriving at prognosis in breast and ovarian cancer. In this study, c‐erbB‐2 expression was investigated in 93 routinely processed cases of gastric carcinoma, using an immunohisto‐chemical technique. c‐erbB‐2 membrane immunoreactivity was observed in 11% (10/93) of tumours, all of whkh were of the well differentiated intestinal type (p < 0.01). Overall, patients with tumours expressing this proto‐oncogene had a significantly improved prognosis (p < 0.05). Within the group of intestinal‐type tumours, those that were c‐erbB‐2‐positive formed a distinct sub‐population which had a better prognosis (p < 0.02), suggesting possible differences in aetiology.

[1]  M. Maltoni,et al.  Heterogeneous protooncogene amplification correlates with tumor progression and presence of metastases in gastric cancer patients. , 1990, Cancer research.

[2]  T. Kameda,et al.  Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification. , 1990, Cancer research.

[3]  M. Ladanyi,et al.  Gene amplification in gastric and esophageal adenocarcinomas. , 1990, Cancer research.

[4]  Teruhiko Yoshida,et al.  K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J. Yokota,et al.  Isolation of an Amplified DNA Sequence in Stomach Cancer , 1990, Japanese journal of cancer research : Gann.

[6]  A. Ullrich,et al.  Expression of the p185 encoded by her2 oncogene in normal and transformed human tissues , 1990, International journal of cancer.

[7]  J. Rhim,et al.  Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas. , 1989, Cancer research.

[8]  D. Barnes.  Breast cancer and a proto-oncogene. , 1989, BMJ.

[9]  W. Gullick,et al.  c‐erbB‐2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study , 1989, The Journal of pathology.

[10]  W Godolphin,et al.  Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. , 1989, Science.

[11]  N. Nomura,et al.  Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. , 1988, Oncogene.

[12]  B. Gusterson,et al.  Immunohistochemical localization of c-erbB-2 in human breast carcinomas. , 1987, Molecular and cellular probes.

[13]  M. Berger,et al.  Expression of the c‐erbB‐2 protein in normal and transformed cells , 1987, International journal of cancer.

[14]  W. Gullick,et al.  OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION , 1987, The Lancet.

[15]  J. Yokota,et al.  AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO , 1986, The Lancet.

[16]  N. Nomura,et al.  Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor , 1986, Nature.

[17]  S. Ming.  Gastric carcinoma: A pathobiological classification , 1977 .

[18]  M. Pike,et al.  Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. , 1977, British Journal of Cancer.

[19]  P. Laurén,et al.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. , 1965, Acta pathologica et microbiologica Scandinavica.