Association of plasma sex hormone levels with functional decline in elderly men and women

Aim:  We aimed to determine whether plasma sex hormone levels are associated with activities of daily living (ADL), cognition, depression and vitality in elderly individuals with functional decline.

[1]  A. Araujo,et al.  Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. , 2002, The Journal of clinical endocrinology and metabolism.

[2]  T. Travison,et al.  Association Between Testosterone and Estradiol and Age‐Related Decline in Physical Function in a Diverse Sample of Men , 2008, Journal of the American Geriatrics Society.

[3]  S. Moffat Effects of Testosterone on Cognitive and Brain Aging in Elderly Men , 2005, Annals of the New York Academy of Sciences.

[4]  T. Seeman,et al.  Menopause transition stage and endogenous estradiol and follicle-stimulating hormone levels are not related to cognitive performance: cross-sectional results from the study of women's health across the nation (SWAN). , 2007, Journal of women's health.

[5]  K. Khaw,et al.  Dehydroepiandrosterone sulfate and mortality in elderly men and women. , 2001, The Journal of clinical endocrinology and metabolism.

[6]  S. Cummings,et al.  Endogenous testosterone levels, physical performance, and fall risk in older men. , 2006, Archives of internal medicine.

[7]  S. Resnick,et al.  Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. , 2002, The Journal of clinical endocrinology and metabolism.

[8]  J. Dartigues,et al.  Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[9]  P A Parmelee,et al.  Geriatric Depression Scale , 2002 .

[10]  G. Andriole Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial , 2008 .

[11]  T. Yanase,et al.  Serum concentrations of dehydroepiandrosterone sulfate (DHEA‐S) in oldest old Japanese women correlate with cognitive activity rather than activities of daily living , 2006 .

[12]  L. Woodhouse,et al.  Changes in Muscle Mass, Muscle Strength, and Power but Not Physical Function Are Related to Testosterone Dose in Healthy Older Men , 2008, Journal of the American Geriatrics Society.

[13]  Y. Ouchi,et al.  Vitality Index as a useful tool to assess elderly with dementia , 2002 .

[14]  M. Lawton,et al.  Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living , 1969 .

[15]  J. Berlin,et al.  Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. , 1999, The Journal of clinical endocrinology and metabolism.

[16]  M. Lawton,et al.  Assessment of older people: self-maintaining and instrumental activities of daily living. , 1969, The Gerontologist.

[17]  K. Yaffe,et al.  Serum Estrogen Levels, Cognitive Performance, and Risk of Cognitive Decline in Older Community Women , 1998, Journal of the American Geriatrics Society.

[18]  Matthew T. Haren,et al.  Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women. , 2007, Maturitas.

[19]  H. Perry,et al.  Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. , 1997, The Journal of clinical endocrinology and metabolism.

[20]  S. Mellon,et al.  Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[21]  F. Mahoney,et al.  FUNCTIONAL EVALUATION: THE BARTHEL INDEX. , 2018, Maryland state medical journal.

[22]  A. von zur Mühlen,et al.  Age‐related changes of serum sex hormones, insulin‐like growth factor‐1 and sex‐hormone binding globulin levels in men: cross‐sectional data from a healthy male cohort , 2000, Clinical endocrinology.

[23]  E. Metter,et al.  Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. , 2001, The Journal of clinical endocrinology and metabolism.

[24]  A. Matsumoto,et al.  Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. , 2005, The Journal of clinical endocrinology and metabolism.

[25]  S. Asthana,et al.  Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment , 2005, Neurology.

[26]  S. Barger,et al.  Neuroprotection by dehydroepiandrosterone-sulfate: role of an NFkappaB-like factor. , 1998, Neuroreport.

[27]  J. Dartigues,et al.  Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[28]  F. I. Mahonery Functional evaluation : Barthel index , 1965 .

[29]  E. Barrett-Connor,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study , 2022 .

[30]  T. Bush,et al.  Dehydroepiandrosterone and dehydroepiandrosterone sulfate: their relation to cardiovascular disease. , 1991, Epidemiologic reviews.

[31]  D. Grobbee,et al.  Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women. , 2006, Maturitas.

[32]  Kristine Yaffe,et al.  Sex Hormones and Cognitive Function in Older Men , 2002, Journal of the American Geriatrics Society.

[33]  M. Rowan,et al.  Endogenous sex hormone levels in postmenopausal women with Alzheimer's disease. , 2001, The Journal of clinical endocrinology and metabolism.

[34]  Y. Ouchi,et al.  Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men , 2006, Hypertension Research.

[35]  D. Grobbee,et al.  Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. , 2000, The Journal of clinical endocrinology and metabolism.

[36]  A. Mazur Biosocial models of deviant behavior among male army veterans , 1995, Biological Psychology.

[37]  E. Barrett-Connor,et al.  Endogenous sex hormones and cognitive function in older men. , 1999, The Journal of clinical endocrinology and metabolism.

[38]  M. Visser,et al.  The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women , 2005, Clinical endocrinology.

[39]  Zdenek Kolar,et al.  Distribution of nuclear receptors for steroid hormones in the human brain: a preliminary study. , 2007, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[40]  Diederick E Grobbee,et al.  Endogenous sex hormones in men aged 40-80 years. , 2003, European journal of endocrinology.

[41]  E. D. de Haan,et al.  Endogenous sex hormone levels and cognitive function in aging men , 2005, Neurology.

[42]  Claudio Cobelli,et al.  DHEA in elderly women and DHEA or testosterone in elderly men. , 2006, The New England journal of medicine.

[43]  S. Asthana,et al.  Testosterone supplementation improves spatial and verbal memory in healthy older men , 2001, Neurology.

[44]  N. Goldman,et al.  Sex differences in the relationship between DHEAS and health , 2007, Experimental Gerontology.

[45]  E. Barrett-Connor,et al.  Cognitive Function and Endogenous Sex Hormones in Older Women , 1999, Journal of the American Geriatrics Society.

[46]  A. Araujo,et al.  The Relationship Between Depressive Symptoms and Male Erectile Dysfunction: Cross-Sectional Results From the Massachusetts Male Aging Study , 1998, Psychosomatic medicine.

[47]  E. Metter,et al.  Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men. , 2002, American journal of physiology. Endocrinology and metabolism.

[48]  K. Khaw,et al.  Dehydroepiandrosterone sulphate and Mortality in Elderly Men and Women , 2001 .

[49]  J. Janowsky,et al.  The role of androgens in cognition and brain aging in men , 2006, Neuroscience.

[50]  T. Travison,et al.  The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. , 2007, The Journal of clinical endocrinology and metabolism.

[51]  S. Davis,et al.  Androgen levels in adult females: changes with age, menopause, and oophorectomy. , 2005, The Journal of clinical endocrinology and metabolism.

[52]  S. Wallenstein,et al.  Relationships of sex hormone levels to dependence in activities of daily living in the frail elderly. , 2001, Maturitas.