2-Hydroxyethyl Methacrylate (HEMA): Chemical Properties and Applications in Biomedical Fields

Abstract 2-Hydroxyethyl methacrylate is a monomer with numerous applications. More than 1500 publications have been devoted to this product since 1967,2000 publications or patents mention the corresponding polymer, and a greater number of works involve copolymers incorporating this monomer.

[1]  N. Efron,et al.  Visual Decrement with Deposit Accumulation on HEMA Contact Lenses , 1988, American journal of optometry and physiological optics.

[2]  P. Vondracek,et al.  Silicone rubber-hydrogel composites as polymeric biomaterials. I. Biological properties of the silicone rubber-p(HEMA) composite. , 1990, Biomaterials.

[3]  B. Holden,et al.  Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. , 1984, Investigative ophthalmology & visual science.

[4]  H. Ringsdorf,et al.  Self-organization of polymeric lipids with hydrophilic spacers in side groups and main chain: investigation in monolayers and multilayers , 1987 .

[5]  B. Tighe,et al.  Requirements for cell spreading on polyHEMA coated culture substrates. , 1984, Cell biology international reports.

[6]  T. Tsuruta,et al.  Reactivity of a polyamine macromonomer in radical copolymerization with 2-hydroxyethyl methacrylate† , 1989 .

[7]  F. Macritchie.  Proteins at interfaces. , 1978, Advances in protein chemistry.

[8]  A. Gourdenne,et al.  Activation of radical polymerization by microwaves—I. Polymerization of 2-hydroxyethyl methacrylate , 1983 .

[9]  M. A. D. Silva,et al.  Photosensitized grafting of acrylamide and hydroxyethyl methacrylate onto cellulose , 1987 .

[10]  E. Pişkin,et al.  Swelling of PHEMA based membranes in ethanol and their nitroglycerin permeabilities. , 1990, Biomaterials, artificial cells, and artificial organs.

[11]  P. M. Kildea,et al.  A histologic comparison of Hydron and zinc oxide-eugenol as endodontic filling materials in the primary teeth of dogs. , 1984, Oral surgery, oral medicine, and oral pathology.

[12]  M. Kumakura.  Mechanical properties of polymeric membranes obtained by radiation cast-polymerization of hydroxyalkyl and hydroxypolyethyleneglycol methacrylate monomers. , 1986, Journal of biomedical materials research.

[13]  A. Mansingh,et al.  Dielectric study of polyacrylonitrile, poly-2-hydroxyethyl methacrylate and their copolymers , 1979 .

[14]  Masaru Yoshida,et al.  Controlled Release of 5-Fluorouracil from Adsorbents Containing Matrices Polymerized by Radiation , 1979 .

[15]  E. Eckstein,et al.  The interaction of urea with the generic class of poly(2-hydroxyethyl methacrylate) hydrogels. , 1984, Journal of biomedical materials research.

[16]  Wen-Yen Chiang,et al.  Preparation and properties of photocurable unsaturated oligoester acrylourethanes , 1987 .

[17]  T. Kagiya,et al.  Effect of Acetylene on the γ-Ray Crosslinking Polymerization of Various Kinds of Acrylic Monomers , 1976 .

[18]  R. Molday,et al.  Synthesis and Reactions of Hydrophilic Functional Microspheres for Immunological Studies , 1979 .

[19]  K. Itoh,et al.  Investigation of self-etching dentin primers. , 1989, Dental materials : official publication of the Academy of Dental Materials.

[20]  M. Sefton,et al.  Insulin permeability of hydrophilic polyacrylate membranes. , 1980, Journal of pharmaceutical sciences.

[21]  J. Andrade,et al.  Adsorption of low density lipoproteins onto selected biomedical polymers. , 1987, Journal of biomedical materials research.

[22]  Y. Avny,et al.  The in situ polymerization of vinyl monomers in polyester yarns , 1978 .

[23]  G. Cope.  Low-temperature embedding in water-miscible methacrylates after treatment with antifreezes. , 1968, Journal. Royal Microscopical Society.

[24]  J. Šulc,et al.  Physicochemical aspects of the giant multinucleate cell formation. , 1987, Experimental and molecular pathology.

[25]  D. Chappard.  Uniform polymerization of large blocks in glycol methacrylate at low temperature with special reference to enzyme histochemistry , 1985 .

[26]  A. Denizli,et al.  Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure. , 1988, Biomaterials.

[27]  J. Antonucci,et al.  Formation of hydroxyapatite in hydrogels from tetracalcium phosphate/dicalcium phosphate mixtures. , 1989, The Journal of Nihon University School of Dentistry.

[28]  M. Blumenthal,et al.  Preliminary study of hydrophilic hydrogel intraocular lens implants in cats. , 1984, Journal - American Intra-Ocular Implant Society.

[29]  M. Miyata,et al.  Functional monomers and polymers, 115. Permeability of hydrogel membranes consisting of copolymers containing pendant nucleic acid bases , 1984 .

[30]  H. Yasuda.  Basic consideration of permeability of polymer membrane to dissolved oxygen , 1967 .

[31]  H. Yamanaka,et al.  Biodegradable implant composites for local therapy , 1987 .

[32]  B. Ratner,et al.  Interaction of urea with poly(2‐hydroxyethyl methacrylate) hydrogels , 1972 .

[33]  S. Yoshikawa,et al.  Complement-induced thrombus formation on the surface of poly(N-vinylpyrrolidone)-grafted polyethylene. , 1987, Biomaterials.

[34]  Y. Itoh,et al.  Synthesis of an electron‐acceptor polymer and its charge transfer complex with an electron‐donor polymer , 1985 .

[35]  D. Bombick,et al.  Acrylate polymers containing a carbamate-linked herbicide substituent , 1982 .

[36]  P. Hall,et al.  Steroidogenesis in adrenal tumor cells: influence of cell shape. , 1987, Endocrinology.

[37]  A. Mikos,et al.  Prediction of feed comonomer and solvent composition for monomer-free polymer production. , 1987, Biomaterials.

[38]  Makoto Tanaka,et al.  Cation binding properties of poly(crown ether)s with photodimerizable groups. Enhanced cation binding ability via a photochemical template effect , 1985 .

[39]  J. Andrade,et al.  Thermal and pulse NMR analysis of water in poly(2-hydroxyethyl methacrylate) , 1981 .

[40]  C. Frank,et al.  Twisted Intramolecular Charge-Transfer Phenomenon as a Fluorescence Probe of Microenvironment: Effect of Polymer Concentration on Local Viscosity and Microscopic Polarity around a Polymer Chain of Poly(methyl methacrylate) , 1987 .

[41]  T. P. Davis,et al.  Copolymerizations involving N-vinyl-2-pyrrolidone , 1985 .

[42]  F. Lockwood,et al.  Polymerization in nonaqueous lyotropic liquid crystals with a polymerizable solvent , 1987 .

[43]  L. Fishbein,et al.  Gas chromatography of hydroxyethyl derivatives. , 1967, Journal of chromatography.

[44]  H. Edelhauser,et al.  Drug uptake and release by a hydrogel intraocular lens and the human crystalline lens , 1989, Journal of cataract and refractive surgery.

[45]  C. J. Lee,et al.  Preparation of spherical encapsulation of activated carbons and their adsorption capacity of typical uremic toxins. , 1990, Journal of biomedical materials research.

[46]  W. Dobelle,et al.  Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility. , 1983, Journal of biomedical materials research.

[47]  B. Levy.  Calcium deposits on glyceryl methyl methacrylate and hydroxyethyl methacrylate contact lenses. , 1984, American Journal of Optometry and Physiological Optics.

[48]  R. L. Broughton,et al.  Microencapsulation of CHO cells in a hydroxyethyl methacrylate-methyl methacrylate copolymer. , 1987, Biomaterials.

[49]  L. Nicolais,et al.  Physical characterization of microporous poly(2-hydroxyethyl methacrylate) gels. , 1981, Journal of biomedical materials research.

[50]  G. Barrett,et al.  Multicenter trial of an intraocular hydrogel lens implant , 1987, Journal of cataract and refractive surgery.

[51]  N. Peppas,et al.  The structure of highly crosslinked poly(2-hydroxyethyl methacrylate) hydrogels. , 1985, Journal of biomedical materials research.

[52]  J. Vairon,et al.  Reversible immobilization of drugs on a hydrogel matrix, 1. Synthesis of unsaturated chloramphenicol derivatives and copolymerization with 2-hydroxyethyl methacrylate , 1986 .

[53]  M Yoshida,et al.  Controlled slow release of chemotherapeutic drugs for cancer from matrices prepared by radiation polymerization at low temperatures. , 1980, Journal of biomedical materials research.

[54]  J. Andrade,et al.  Thermal and dynamic mechanical relaxation behavior of stereoregular poly(2‐hydroxyethyl methacrylate) , 1980 .

[55]  A. Hoffman,et al.  Cell adhesion to polymeric materials: implications with respect to biocompatibility. , 1975, Journal of biomedical materials research.

[56]  V. Trinkaus-Randall,et al.  Modified hydroxyethylmethacrylate hydrogels as a modelling tool for the study of cell-substratum interactions. , 1989, Journal of cell science.

[57]  C. Skorpik,et al.  Evaluation of the first 60 cases of poly HEMA posterior chamber lenses implanted in the sulcus , 1989, Journal of cataract and refractive surgery.

[58]  T. Iizawa,et al.  Study of photopolymers. XVI. Novel syntheses of the polymers with azidonitrobenzoyl groups and their photochemical and thermochemical reactions , 1981 .

[59]  J. Kálal.  The use of methacrylic polymers in medicine , 1984 .

[60]  J. Feijen,et al.  Adhesion of coagulase-negative staphylococci to methacrylate polymers and copolymers. , 1986, Journal of biomedical materials research.

[61]  M. Reinecke.  Neurotensin. Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone. , 1985, Progress in histochemistry and cytochemistry.

[62]  B. Jansen,et al.  Modification of polyetherurethane for biomedical application by radiation-induced grafting. I. Grafting procedure, determination of mechanical properties, and chemical modification of grafted films. , 1985, Journal of biomedical materials research.

[63]  J. Rázga,et al.  Thermal degradation of poly-2-hydroxyethyl methacrylate by pyrolysis gas chromatography , 1975 .

[64]  T. Nakaya,et al.  Synthesis and properties of polymers containing 4‐ or 4′‐chalconecarbonyl groups in side chains , 1975 .

[65]  A. Hirao,et al.  Polymerization of monomers containing functional groups protected by trialkylsilyl groups. 5. Synthesis of poly(2-hydroxyethyl methacrylate) with a narrow molecular weight distribution by means of anionic living polymerization , 1986 .

[66]  Yoshihiro Ito,et al.  Design and Synthesis of Biocompatible Polymeric Materials , 1988 .

[67]  D. Chappard,et al.  Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies. , 1983, Basic and applied histochemistry.

[68]  B D Ratner,et al.  Glucose-sensitive membranes containing glucose oxidase: activity, swelling, and permeability studies. , 1985, Journal of biomedical materials research.

[69]  E. Eckstein,et al.  The interaction of calcium with HEMA/MAA copolymers , 1987 .

[70]  R. M. Franklin,et al.  A simple procedure for extracting methacrylic acid from water-miscible methacrylates. , 1981, Stain technology.

[71]  W. Bernhard,et al.  Recent modifications of the glycol methacrylate embedding procedure. , 1967, Journal of ultrastructure research.

[72]  P. Vasudevan,et al.  Effect of anionic polymeric hydrogels on spermatozoa motility. , 1984, Biomaterials.

[73]  B. Polak,et al.  Deep corneal stromal opacities in long-term contact lens wear. , 1990, Ophthalmology.

[74]  M. Refojo.  Hydrophobic interaction in poly(2-hydroxyethyl methacrylate) homogeneous hydrogel. , 1967, Journal of polymer science. Part A-1, Polymer chemistry.

[75]  Determination of the apparent activation energy of dielectric relaxation phenomena by means of the representation of ∊'' as a function of T at constant frequency , 1984 .

[76]  C. Pinazzi,et al.  Polymerisation de monomeres a structures biologiques , 1978 .

[77]  E. Asmussen,et al.  Materials Science Bond Strength Between Dentin and Restorative Resins Mediated by Mixtures of HEMA and Glutaraldehyde , 1984, Journal of dental research.

[78]  O. Wichterle,et al.  Water-Soluble Methacrylates as Embedding Media for Preparation of Ultra-Thin Sections , 1960, Nature.

[79]  G. Johnson,et al.  Cell responses to biomaterials. I: Adhesion and growth of vascular endothelial cells on poly(hydroxyethyl methacrylate) following surface modification by hydrolytic etching. , 1987, Journal of biomedical materials research.

[80]  N. B. Dobrova,et al.  Polyethylene/hydrophilic polymer blends for biomedical applications. , 1987, Biomaterials.

[81]  S. Lora,et al.  Low temperature radiation-induced polymerization of 2-hydroxyethyl methacrylate for polymer matrix preparation , 1987 .

[82]  R. Greenley.  An Expanded Listing of Revised Q and e Values , 1980 .

[83]  T. Okano,et al.  Control of drug concentration-time profiles in vivo by zero-order transdermal delivery systems , 1987 .

[84]  D. Attwood,et al.  The influence of gel formulation on the diffusion of salicylic acid in polyHEMA hydrogels , 1982, The Journal of pharmacy and pharmacology.

[85]  J. Benoit,et al.  Synthese de polymeres porteurs d'un antivitamine k, la phenindione , 1979 .

[86]  S. Kim,et al.  Progestin permeation through polymer membrane V: Progesterone release from monolithic hydrogel devices. , 1981, Journal of pharmaceutical sciences.

[87]  C. P. Sharma,et al.  Permeability of PEUU Membranes: Their Modification Towards Blood Compatibility , 1988, Journal of biomaterials applications.

[88]  G. Moad,et al.  Influences of the initiation and termination reactions on the molecular weight distribution and compositional heterogeneity of functional copolymers: an application of Monte Carlo simulation , 1987 .

[89]  D. Kristol,et al.  Preparation of new blocked diisocyanate for dental application , 1987 .

[90]  S. W. Kim,et al.  Preformulation of an Ara-A transdermal delivery system: Membrane fabrication and characterization , 1987 .

[91]  K. Ishihara,et al.  Preparation of polymer membranes with responsive function for amino compounds , 1982 .

[92]  P. J. Shannon.  Photopolymerization in Cholesteric Mesophases , 1984 .

[93]  I. K. Varma,et al.  Copolymerization of 2-hydroxyethyl methacrylate with alkyl acrylates , 1976 .

[94]  O. Wichterle,et al.  Hydrophilic Gels for Biological Use , 1960, Nature.

[95]  Koichi Ito,et al.  Solvent Effects in Radical Copolymerization between Hydrophilic and Hydrophobic Monomers; 2-Hydroxyethyl Methacrylate and Lauryl Methacrylate , 1985 .

[96]  T. Nakaya,et al.  Polymeric phospholipid analogues, 14. The convenient preparation of a vinyl monomer containing a phospholipid analogue , 1982 .

[97]  Jindřich Kopeček,et al.  Permeability of membranes containing ionogenic groups , 1971 .

[98]  E. Asmussen,et al.  Dentin-polymer bond mediated by glutaraldehyde/HEMA. , 1985, Scandinavian journal of dental research.

[99]  K. Fischer,et al.  Synthesis and properties of acrylic polymers with ω-functionalized side chains† , 1988 .

[100]  Isao Kaetsu,et al.  Immobilization of microbial cells in membrane form by radiation‐induced cast‐polymerization , 1983 .

[101]  Y. Avny,et al.  The initiation of in situ polymerization of vinyl monomers in polyester by glow discharge , 1980 .

[102]  R. Greer,et al.  Evaluation of in vivo adsorption of blood elements onto hydrogel-coated silicone rubber by scanning electron microscopy and fourier transform infrared spectroscopy. , 1985, Journal of biomedical materials research.

[103]  M. Fusek,et al.  Synthesis of high-capacity immunoaffinity sorbents with oriented immobilized immunoglobulins or their Fab' fragments for isolation of proteins. , 1988, Journal of chromatography.

[104]  H. Junginger,et al.  The physico-chemical characterization of poly (2-hydroxyethyl methacrylate-co-methacrylic acid: 2. Effect of water, PEG 400 and PEG 6000 on the glass transition temperature , 1989 .

[105]  V. Cermak,et al.  Solution copolymerization of styrene and 2-hydroxyethyl mechacrylate. , 1986 .

[106]  N. Peppas,et al.  Effect of degree of crosslinking on water transport in polymer microparticles , 1985 .

[107]  B. Sedláček,et al.  Turbidity of transparent swollen gels , 1982 .

[108]  R. Arshady,et al.  Copolymerization of N-vinyl-2-pyrrolidone with 2,4,5-trichlorophenyl acrylate and with 2-hydroxyethyl methacrylate. Reactivity ratios and molecular weights , 1985 .

[109]  M. Novák,et al.  The initial stage of calcification in porous hydrophilic polymers. , 1981, Journal of biomedical materials research.

[110]  Jen-Ming Yang,et al.  Preparation and properties of a biomaterial: HEMA grafted SBS by γ-ray irradiation , 1988 .

[111]  K. P. Rao,et al.  In vivo biocompatibility of collagen-poly(hydroxyethyl methacrylate) hydrogels. , 1990, Biomaterials.

[112]  P. O. Gerrits,et al.  Glycol methacrylate embedding in histotechnology: the hematoxylin-eosin stain as a method for assessing the stability of glycol methacrylate sections. , 1987, Stain technology.

[113]  W. Dreyer,et al.  Functional polymeric microspheres based on 2-hydroxyethyl methacrylate for immunochemical studies. , 1976, Macromolecules.

[114]  J. G. Ribelles,et al.  The β dielectric relaxation in some methacrylate polymers , 1985 .

[115]  M. Pocci,et al.  Synthesis of tailor-made copolymers containing 1,4-benzodioxane systems for pH controlled selective flocculation of mineral dispersions , 1988 .

[116]  H. Yamanaka,et al.  Studies of the slow releasing of testosterone from radiation-polymerized testicular prostheses implanted subcutaneously in the back of castrated rabbits. , 1987, Biomaterials.

[117]  J. Kálal,et al.  Copolymerizations of 2-hydroxyethylmethacrylate with vinylpyridines and with N-substituted methacrylamides , 1974 .

[118]  T. Okano,et al.  Hydrophilic-hydrophobic microdomain surfaces having an ability to suppress platelet aggregation and their in vitro antithrombogenicity. , 1986, Journal of biomedical materials research.

[119]  T. Okano,et al.  The influence of hydrophilic and hydrophobic domains on water wettability of 2-hydroxyethyl methacrylate-styrene copolymers , 1978 .

[120]  J. Benoit,et al.  Synthèse et polymérisation de polyméthacrylates porteurs de la quinine. Etude comparée de la toxicité et de l'immunogénicité des formes libres et polymériques , 1978 .

[121]  M. Busin,et al.  Sustained gentamicin release by presoaked medicated bandage contact lenses. , 1988, Ophthalmology.

[122]  J. Kopeček,et al.  Mechanismus der Dreidimensionalen Polymerisation von Glykolmethacrylaten , 1967 .

[123]  R. Semba.  Contributions to semithin sectioning on a conventional rotary microtome. , 1979, Stain technology.

[124]  R. L. Broughton,et al.  Preparation and characterization of thermoplastic polymers from hydroxyalkyl methacrylates , 1987 .

[125]  J. Šulc,et al.  Intraocular biocompatibility of hydroxyethyl methacrylate and methacrylic acid copolymer/partially hydrolyzed poly(2-hydroxyethyl methacrylate). , 1987, Journal of biomedical materials research.

[126]  R. Fort,et al.  Intrinsic viscosity-molecular weight relationships for poly(2-hydroxyethyl methacrylate) , 1976 .

[127]  I. Sakai,et al.  A13C Nuclear Magnetic Resonance Study of Covalently Cross-Linked Gels. Effect of Chemical Composition, Degree of Cross-Linking, and Temperature to Chain Mobility , 1978 .

[128]  E. Asmussen,et al.  Dentine and enamel bonding agents. , 1987, International dental journal.

[129]  B. Tighe,et al.  Synthetic hydrogels: 1. Hydroxyalkyl acrylate and methacrylate copolymers - water binding studies , 1987 .

[130]  P. Gerrits,et al.  A new, less toxic polymerization system for the embedding of soft tissues in glycol methacrylate and subsequent preparing of serial sections , 1983, Journal of microscopy.

[131]  R. D. Calleja.  Dielectric γ relaxation in poly(2‐hydroxyethyl methacrylate) , 1979 .

[132]  H. Höcker,et al.  Electrocoating of carbon fibres with polyaniline and poly(hydroxyalkyl methacrylates) , 1989 .

[133]  M. Kumakura,et al.  Initial stage in radiation polymerization of hydroxyethyl methacrylate-water system at low temperatures , 1983 .

[134]  A. Ben-Ze'ev,et al.  Virus replication in infected epithelial cells is coupled to cell shape‐responsive metabolic controls , 1983, Journal of cellular physiology.

[135]  M. Štol,et al.  Poly(2-hydroxyethyl methacrylate)--collagen composites which promote muscle cell differentiation in vitro. , 1985, Biomaterials.

[136]  V. Hasırcı,et al.  Immobilization of glucose oxidase in poly(2-hydroxyethyl methacrylate) membranes. , 1987, Biomaterials.

[137]  J. Corliss,et al.  Practical methods in electron microscopy , 1973 .

[138]  J. Hanstede,et al.  The effects of embedding in water‐soluble plastics on the final dimensions of liver sections , 1983, Journal of microscopy.

[139]  C. L. Ruddell.  Embedding media for 1-2 micron sectioning. 2. Hydroxyethyl methacrylate combined with 2-butoxyethanol. , 1967, Stain technology.

[140]  M. Sefton,et al.  The equilibrium water content of some thermoplastic hydroxyalkyl methacrylate polymers , 1988 .

[141]  I. K. Varma,et al.  Copolymerization of 2-hydroxyethyl methacrylate with alkylacrylates. Temperature dependence of monomer reactivity ratios , 1977 .

[142]  W H Dobelle,et al.  Macroporous hydrogel membranes for a hybrid artificial pancreas. I. Synthesis and chamber fabrication. , 1983, Journal of biomedical materials research.

[143]  I. Constable,et al.  Clinical results of hydrogel lens implantation , 1986, Journal of cataract and refractive surgery.

[144]  P. Bartl,et al.  Water-soluble methacrylate as an embedding medium for the preparation of ultrathin sections. , 1960, Journal of ultrastructure research.

[145]  M. Štol,et al.  Calcification of poly(2-hydroxyethyl methacrylate)-collagen composites implanted in rats. , 1987, Biomaterials.

[146]  P. C. Jain,et al.  Copolymerization of acrylonitrile with 2‐hydroxyalkyl methacrylates , 1979 .

[147]  K. Sall,et al.  Effect of the Nd:YAG laser on polymethylmethacrylate, HEMA copolymer, and silicone intraocular materials , 1987, Journal of cataract and refractive surgery.

[148]  C. Bamford,et al.  Studies of the esterification of dextran: routes to bioactive polymers and graft copolymers , 1986 .

[149]  Nikolaos A. Peppas,et al.  Solute diffusion in swollen membranes. IX: Scaling laws for solute diffusion in gels , 1988 .

[150]  C. Bunel,et al.  Reversible immobilization of drugs on a hydrogel matrix, 2. Diffusion of free chloramphenicol from poly(2‐hydroxyethyl methacrylate) hydrogels , 1990 .

[151]  J. Feijen,et al.  Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities. , 1985, Biomaterials.

[152]  N. Peppas,et al.  Correlation between mesh size and equilibrium degree of swelling of polymeric networks. , 1989, Journal of biomedical materials research.

[153]  J. Anderson,et al.  Surface modification of soft contact lenses: silanization, wettability and lysozyme adsorption studies. , 1986, Biomaterials.

[154]  M. Pocci,et al.  Synthesis of tailor‐made copolymers containing 1,3‐benzodioxole systems for selective flocculation of minerals , 1987 .

[155]  J. Kálal,et al.  Hydrogels in endovascular embolization. I. Spherical particles of poly(2-hydroxyethyl methacrylate) and their medico-biological properties. , 1986, Biomaterials.

[156]  Oscillation of electrical current in water-swollen polyelectrolyte gels , 1988 .

[157]  D. Apple,et al.  Activation of complement in human serum by some synthetic polymers used for intraocular lenses. , 1987, Biomaterials.

[158]  C. Bamford,et al.  Studies on functionalizing and grafting to poly(ether-urethanes) , 1983 .

[159]  K. Dušek,et al.  Phase separation in poly(2-hydroxyethyl methacrylate) gels in the presence of water , 1971 .

[160]  Subcutaneous polymeric matrix system p(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). II: Release kinetics. , 1988, Biomaterials.

[161]  H. Junginger,et al.  The physico-chemical characterization of poly (2-hydroxyethyl methacrylate-co-methacrylic acid): 1. Effect of PEG 400 on the tacticity and reactivity ratios , 1989 .

[162]  Y. Nishio,et al.  Morphological studies of liquid‐crystalline cellulose derivatives. I. Liquid‐crystalline characteristics of hydroxypropyl cellulose in 2‐hydroxyethyl methacrylate solutions and in polymer composites prepared by bulk polymerization , 1985 .

[163]  Masaru Yoshida,et al.  Enzyme immobilization by radiation‐induced polymerization of 2‐hydroxyethyl methacrylate at low temperatures , 1979, Biotechnology and bioengineering.

[164]  C. Eriksson.  Surface energies and the bone induction principle. , 1985, Journal of biomedical materials research.

[165]  K. Smalla,et al.  Influence of Salts on the Covalent Immobilization of Proteins to Modified Copolymers of 2‐Hydroxyethyl Methacrylate with Ethylene Dimethacrylate , 1988, Biotechnology and applied biochemistry.

[166]  T. Okano,et al.  Suppression of platelet activity on microdomain surfaces of 2-hydroxyethyl methacrylate-polyether block copolymers. , 1986, Journal of biomedical materials research.

[167]  T. P. Davis,et al.  Copolymerisation of 2-hydroxyethyl methacrylate with siloxanyl monomers , 1984 .

[168]  M. Cole.  An “azo” substitute for benzoyl peroxide in polymerizing glycol methacrylate (GMA) , 1979 .

[169]  D. Mirth,et al.  Development and in vitro Evaluation of an Intra-oral Controlled-release Delivery System for Chlorhexidine , 1989, Journal of dental research.

[170]  C. R. Nair,et al.  Copolymerization of diethyl 2‐(methacryloyloxy) ethyl phosphate with alkyl acrylates: Reactivity ratios and glass transition temperatures , 1988 .

[171]  E. Eckstein,et al.  Effects of low levels of methacrylic acid on the swelling behavior of poly(2-hydroxyethyl methacrylate) , 1984 .

[172]  Robert Y. M. Huang,et al.  Synthesis and transport properties of poly(vinyl alcohol) acrylonitrile/2-hydroxyethyl methacrylate membranes. I: Synthesis of poly(vinyl alcohol) acrylonitrile 2-hydroxyethyl methacrylate graft copolymer , 1988 .

[173]  F. Catalina,et al.  Photochemistry of thioxanthones—V. A polymerization, spectroscopic and flash photolysis study on novel water soluble methyl substituted 3-(9-oxo-9H-thioxanthene-2-yloxyl)N,N,N-trimethyl-1-propanaminium salts , 1986 .

[174]  B. Tighe,et al.  Cellular interactions with synthetic polymer surfaces in culture. , 1985, Biomaterials.

[175]  A de Boisfleury-Chevance,et al.  Locomotion of white blood cells: a biophysical analysis. , 1989, Blood cells.

[176]  D. Chappard,et al.  Embedding iliac bone biopsies at low temperature using glycol and methyl methacrylates. , 1983, Stain technology.

[177]  B. Ratner,et al.  Rat peritoneal macrophage adhesion to hydroxyethyl methacrylate-ethyl methacrylate copolymers and hydroxystyrene-styrene copolymers. , 1985, Journal of biomedical materials research.

[178]  A. Jayakrishnan,et al.  Suspension polymerization of 2-hydroxyethyl methacrylate in the presence of polymeric diluents: a novel route to spherical highly porous beads for biomedical applications. , 1990, Journal of biomedical materials research.

[179]  M. Sefton,et al.  Graft copolymer emulsions of sodium alginate with hydroxyalkyl methacrylates for microencapsulation. , 1987, Biomaterials.

[180]  Kunio Nakamura.  Effects of Various Salts on the Mechanical Properties of Homogeneous Poly(2-hydroxyethyl methacrylate) Hydrogels , 1976 .

[181]  J. Andrade,et al.  Preparation and properties of stereoregular poly(hydroxyethyl methacrylate) polymers and hydrogels , 1978 .

[182]  H. Junginger,et al.  Simple gas chromatographic determination of the purity of hydroxyethyl methacrylate. , 1987, Journal of chromatography.

[183]  H. S. Bennett,et al.  Science and art in preparing tissues embedded in plastic for light microscopy, with special reference to glycol methacrylate, glass knives and simple stains. , 1976, Stain technology.

[184]  P. Wright.  Composition and properties of soft lining materials for acrylic dentures. , 1981, Journal of dentistry.

[185]  L. Nicolais,et al.  Dynamic mechanical behavior of poly(2-hydroxyethyl methacrylate)–glass beads composites , 1976 .

[186]  C. McCormick,et al.  Controlled activity polymers. VI: Acrylamide copolymers with structopendent naphthylacetic acid and indoleacetic acid esters: Synthesis and characterization , 1988 .

[187]  T. Horbett,et al.  Complement activation by hydroxyethylmethacrylate-ethylmethacrylate copolymers. , 1987, Journal of biomedical materials research.