Liver pathology in chronic hepatitis C virus infection associated with extrahepatic manifestations

We analyzed microscopic changes in the liver from ten patients infected by hepatitis C virus. All patients developed chronic hepatitis and extrahepatic manifestations as cryoglobulinemia, polyneuropathy, purpura cutanea, Sjogren syndrome and nephritic syndrome. The most severe microscopical changes in the liver were connected with cryoglobulinemia and cutaneous manifestations together with Sjogren syndrome and represented intensive inflammatory lymphoid infiltrates in the lobules, portal spaces with prominent interface hepatitis and septal fibrosis with architectural distortion.