Live‐Cell SERS Endoscopy Using Plasmonic Nanowire Waveguides

Live-cell surface-enhanced Raman spectroscopy (SERS) endoscopy is developed by using plasmonic nanowire waveguides as endoscopic probes. It is demonstrated that the probe insertion does not stress the cell. Opposed to conventional SERS endoscopy, with excitation at the hotspot within the cell, the remote excitation method yields low-background SERS spectra from specific cell compartments with minimal associated photodamage.

[1]  T. Kang,et al.  Electrotriggered, spatioselective, quantitative gene delivery into a single cell nucleus by Au nanowire nanoinjector , 2013 .

[2]  S. Gambhir,et al.  Single-cell photonic nanocavity probes , 2013, CLEO: 2013.

[3]  J. Hofkens,et al.  Silver Nanowires Terminated by Metallic Nanoparticles as Effective Plasmonic Antennas , 2013 .

[4]  Ueli Aebi,et al.  The nanomechanical signature of breast cancer. , 2012, Nature nanotechnology.

[5]  Yury Gogotsi,et al.  Nanoprobes for intracellular and single cell surface-enhanced Raman spectroscopy (SERS) , 2012 .

[6]  Francisco Balzarotti,et al.  Plasmonics meets far-field optical nanoscopy. , 2012, ACS nano.

[7]  Seung-Man Yang,et al.  Nanowire-based single-cell endoscopy. , 2012, Nature nanotechnology.

[8]  J. Hofkens,et al.  Light-assisted nucleation of silver nanowires during polyol synthesis , 2011 .

[9]  Yury Gogotsi,et al.  Multifunctional carbon-nanotube cellular endoscopes. , 2011, Nature nanotechnology.

[10]  C. Du,et al.  Tip-enhanced Raman spectroscopy using single-crystalline Ag nanowire as tip , 2010 .

[11]  Jeremy J. Baumberg,et al.  Understanding the Surface-Enhanced Raman Spectroscopy 'Background' , 2010 .

[12]  J. Hofkens,et al.  Subdiffraction limited, remote excitation of surface enhanced Raman scattering. , 2009, Nano letters.

[13]  Thomas R Huser,et al.  Raman spectroscopy and microscopy of individual cells and cellular components , 2008 .

[14]  N. Halas,et al.  Surface-enhanced Raman spectroscopy of DNA. , 2008, Journal of the American Chemical Society.

[15]  Younan Xia,et al.  Rapid synthesis of silver nanowires through a CuCl- or CuCl2-mediated polyol process , 2008 .

[16]  S. Hell.  Far-Field Optical Nanoscopy , 2007, Science.

[17]  Martin Moskovits,et al.  Surface-enhanced Raman spectroscopy for DNA detection by nanoparticle assembly onto smooth metal films. , 2007, Journal of the American Chemical Society.

[18]  Li Zhang,et al.  Nanorobotic spot welding: controlled metal deposition with attogram precision from copper-filled carbon nanotubes. , 2007, Nano letters.

[19]  Younan Xia,et al.  Observation of plasmon propagation, redirection, and fan-out in silver nanowires. , 2006, Nano letters.

[20]  E. Cocker,et al.  Fiber-optic fluorescence imaging , 2005, Nature Methods.

[21]  C. Plieth,et al.  Calcium: just another regulator in the machinery of life? , 2005, Annals of botany.

[22]  Tuan Vo-Dinh,et al.  Fiber-optic nanosensors for single-cell monitoring , 2005, Analytical and bioanalytical chemistry.

[23]  Marcus Dyba,et al.  Concepts for nanoscale resolution in fluorescence microscopy , 2004, Current Opinion in Neurobiology.

[24]  Byron F. Brehm-Stecher,et al.  Single-Cell Microbiology: Tools, Technologies, and Applications , 2004, Microbiology and Molecular Biology Reviews.

[25]  T. Vo‐Dinh,et al.  Optical sensor for the detection of caspase-9 activity in a single cell. , 2004, Journal of the American Chemical Society.

[26]  Shimon Weiss,et al.  The power and prospects of fluorescence microscopies and spectroscopies. , 2003, Annual review of biophysics and biomolecular structure.

[27]  J Greve,et al.  Nonresonant confocal Raman imaging of DNA and protein distribution in apoptotic cells. , 2003, Biophysical journal.

[28]  Younan Xia,et al.  Large‐Scale Synthesis of Uniform Silver Nanowires Through a Soft, Self‐Seeding, Polyol Process , 2002 .

[29]  Tuan Vo-Dinh,et al.  Antibody-based nanoprobe for measurement of a fluorescent analyte in a single cell , 2000, Nature Biotechnology.

[30]  L. Andrew Lyon,et al.  Unidirectional Plasmon Propagation in Metallic Nanowires , 2000 .

[31]  R. Kopelman,et al.  Submicrometer intracellular chemical optical fiber sensors. , 1992, Science.

[32]  J. T. Syverton,et al.  STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES , 1952, The Journal of experimental medicine.