Updating the Evidence for Physical Activity: Summative Reviews of the Epidemiological Evidence, Prevalence, and Interventions to Promote "Active Aging".

PURPOSE OF THE STUDY There is a global imperative to increase awareness of the emerging evidence on physical activity (PA) among older adults. "Healthy aging" has traditionally focused on preventing chronic disease, but greater efforts are required to reduce frailty and dependency and to maintain independent physical and cognitive function and mental health and well-being. DESIGN AND METHODS This integrated review updates the epidemiological data on PA, summarizes the existing evidence-based PA guidelines, describes the global magnitude of inactivity, and finally describes the rationale for action. The first section updates the epidemiological evidence for reduced cardiometabolic risk, reduced risks of falls, the burgeoning new evidence on improved cognitive function and functional capacity, and reduced risk of depression, anxiety, and dementia. This is followed by a summary of population prevalence studies among older adults. Finally, we present a "review of reviews" of PA interventions delivered from community or population settings, followed by a consideration of interventions among the "oldest-old," where efforts are needed to increase resistance (strength) training and balance. RESULTS This review identifies the global importance of considering "active aging" beyond the established benefits attributed to noncommunicable disease prevention alone. IMPLICATIONS Innovative population-level efforts are required to address physical inactivity, prevent loss of muscle strength, and maintain balance in older adults. Specific investment in healthy aging requires global policy support from the World Health Organization and is implemented at the national and regional levels, in order to reduce the burden of disease and disability among older adults.

[1]  Sarah E Lamb,et al.  Interventions for preventing falls in older people living in the community. , 2009, The Cochrane database of systematic reviews.

[2]  D. Hughes,et al.  Is exercise effective in promoting mental well-being in older age? A systematic review , 2010, Aging & mental health.

[3]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[4]  J. Barthélémy,et al.  Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis , 2015, British Journal of Sports Medicine.

[5]  A. Myers,et al.  Tracking Older Participants of Twelve Physical Activity Classes Over a Three-Year Period , 1998 .

[6]  M. Hopman-Rock,et al.  Prevention of onset and progression of basic ADL disability by physical activity in community dwelling older adults: A meta-analysis , 2013, Ageing Research Reviews.

[7]  D. Fick,et al.  Physical activity promotion in primary care targeting the older adult , 2012, Journal of the American Academy of Nurse Practitioners.

[8]  E. Vingård,et al.  The relationship between physical activity and health‐related quality of life: a systematic review of current evidence , 2010 .

[9]  L. Häberle,et al.  Effects of exercise on fracture reduction in older adults , 2013, Osteoporosis International.

[10]  D. Warburton,et al.  A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults , 2010, The international journal of behavioral nutrition and physical activity.

[11]  E. Scherder,et al.  Executive functions of sedentary elderly may benefit from walking: a systematic review and meta-analysis. , 2014, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[12]  B. Franklin,et al.  American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. , 2011, Medicine and science in sports and exercise.

[13]  Michael E. Miller,et al.  A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[14]  Jo-Ana D Chase,et al.  Physical Activity Interventions Among Older Adults: A Literature Review , 2013, Research and Theory for Nursing Practice.

[15]  Catherine Sherrington,et al.  Prevalence and correlates of participation in fall prevention exercise/physical activity by older adults. , 2012, Preventive medicine.

[16]  Janet E. Fulton,et al.  Adult Participation in Aerobic and Muscle-Strengthening Physical Activities — United States, 2011 , 2013, MMWR. Morbidity and mortality weekly report.

[17]  M. Laurant,et al.  Effectiveness of physical activity interventions for older adults: a review. , 2002, American journal of preventive medicine.

[18]  J. Rey-Lopez,et al.  Sedentary behavior and health outcomes among older adults: a systematic review , 2014, BMC Public Health.

[19]  Catherine Sherrington,et al.  Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations. , 2011, New South Wales public health bulletin.

[20]  Marie-Aline Charles,et al.  The effect of fall prevention exercise programmes on fall induced injuries in community dwelling older adults: systematic review and meta-analysis of randomised controlled trials , 2013, British Journal of Sports Medicine.

[21]  J. Millán-Calenti,et al.  Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trials , 2015, BMC Geriatrics.

[22]  B. Hatfield,et al.  Relationship between physical activity level, telomere length, and telomerase activity. , 2008, Medicine and science in sports and exercise.

[23]  L. Rochester,et al.  Exercise for improving balance in older people. , 2007, The Cochrane database of systematic reviews.

[24]  Robert W Motl,et al.  Physical activity, disability, and quality of life in older adults. , 2010, Physical medicine and rehabilitation clinics of North America.

[25]  Peter R. Cavanagh,et al.  Exercise and physical activity for older adults , 1998 .

[26]  Luc Vanhees,et al.  Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. , 2008, The Cochrane database of systematic reviews.

[27]  P. Sachdev,et al.  The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. , 2013, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[28]  Maria Giné-Garriga,et al.  Physical exercise interventions for improving performance-based measures of physical function in community-dwelling, frail older adults: a systematic review and meta-analysis. , 2014, Archives of physical medicine and rehabilitation.

[29]  Leocadio Rodríguez-Mañas,et al.  Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. , 2013, Rejuvenation research.

[30]  S. Fraser,et al.  Resistance training improves metabolic health in type 2 diabetes: a systematic review. , 2009, Diabetes research and clinical practice.

[31]  G. Batty,et al.  Physical activity and coronary heart disease in older adults. A systematic review of epidemiological studies. , 2002, European journal of public health.

[32]  V. Baert,et al.  Motivators and barriers for physical activity in the oldest old: A systematic review , 2011, Ageing Research Reviews.

[33]  S. Mackintosh,et al.  Does the 'Otago exercise programme' reduce mortality and falls in older adults?: a systematic review and meta-analysis. , 2010, Age and ageing.

[34]  G. Windle Exercise, physical activity and mental well-being in later life , 2014 .

[35]  J. Jakicic,et al.  The influence of exercise and BMI on injuries and illnesses in overweight and obese individuals: a randomized control trial , 2010, The international journal of behavioral nutrition and physical activity.

[36]  A. King,et al.  Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. , 2007, Medicine and science in sports and exercise.

[37]  Jian-Wen Gu,et al.  Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2014, PloS one.

[38]  D Kromhout,et al.  Physical activity and stroke. A meta-analysis of observational data. , 2004, International journal of epidemiology.

[39]  Aline A Scianni,et al.  Progressive resistance exercise improves strength and physical performance in people with mild to moderate Parkinson's disease: a systematic review. , 2013, Journal of physiotherapy.

[40]  Chunhua Shi Interventions for preventing falls in older people in care facilities and hospitals. , 2014, Orthopedic nursing.

[41]  W. Brooks,et al.  Reduced lean mass in early Alzheimer disease and its association with brain atrophy. , 2010, Archives of neurology.

[42]  M. Kreuter,et al.  Social environment and physical activity: a review of concepts and evidence. , 2006, Social science & medicine.

[43]  Y. Wu,et al.  Effect of exercise on physical function, daily living activities, and quality of life in the frail older adults: a meta-analysis. , 2012, Archives of physical medicine and rehabilitation.

[44]  Mary Duggan,et al.  New Canadian physical activity guidelines. , 2011, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[45]  R. Sigal,et al.  Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials , 2015, Acta Diabetologica.

[46]  D. Boldy,et al.  A Systematic Review of Physical Activity Programs for Older People Receiving Home Care Services. , 2015, Journal of aging and physical activity.

[47]  J. Manson,et al.  Muscle-Strengthening and Conditioning Activities and Risk of Type 2 Diabetes: A Prospective Study in Two Cohorts of US Women , 2014, PLoS medicine.

[48]  Louis Bherer,et al.  Cognitive plasticity in older adults: effects of cognitive training and physical exercise , 2015, Annals of the New York Academy of Sciences.

[49]  Simon Briscoe,et al.  Exercise-based rehabilitation for heart failure: systematic review and meta-analysis , 2015, Open Heart.

[50]  Betsy Jane Becker,et al.  Physical activity and psychological well-being in advanced age: a meta-analysis of intervention studies. , 2005, Psychology and aging.

[51]  Nancy K Latham,et al.  Progressive resistance strength training for improving physical function in older adults. , 2009, The Cochrane database of systematic reviews.

[52]  M. Fiatarone Singh,et al.  Exercise, nutrition and managing hip fracture in older persons , 2014, Current opinion in clinical nutrition and metabolic care.

[53]  A F Kramer,et al.  Social relations, physical activity, and well-being in older adults. , 2000, Preventive medicine.

[54]  Ananda Sen,et al.  Influence of resistance exercise on lean body mass in aging adults: a meta-analysis. , 2011, Medicine and science in sports and exercise.

[55]  Organización Mundial de la Salud Global Health and Aging , 2011 .

[56]  Anthony A. Vandervoort,et al.  The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review , 2011, Journal of aging research.

[57]  T. Valenzuela Efficacy of progressive resistance training interventions in older adults in nursing homes: a systematic review. , 2012, Journal of the American Medical Directors Association.

[58]  L. Diep,et al.  Association of physical activity level and stroke outcomes in men and women: a meta-analysis. , 2010, Journal of women's health.

[59]  S. Blair,et al.  Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy , 2012, BDJ.

[60]  K. Chad,et al.  Home versus center based physical activity programs in older adults. , 2005, The Cochrane database of systematic reviews.

[61]  P. Heyn,et al.  Endurance and strength training outcomes on cognitively impaired and cognitively intact older adults: A meta-analysis , 2008, The journal of nutrition, health & aging.

[62]  B. Schoenfeld,et al.  Muscular adaptations in low- versus high-load resistance training: A meta-analysis , 2016, European journal of sport science.

[63]  D. Warburton,et al.  Physical activity and functional limitations in older adults: a systematic review related to Canada's Physical Activity Guidelines , 2010, The international journal of behavioral nutrition and physical activity.

[64]  Rhonda Orr,et al.  Efficacy of Progressive Resistance Training on Balance Performance in Older Adults , 2008, Sports medicine.

[65]  Adrian Bauman,et al.  Accelerometer-based measures in physical activity surveillance: current practices and issues , 2014, British Journal of Sports Medicine.

[66]  Jerson Laks,et al.  Physical Exercise and Clinically Depressed Patients: A Systematic Review and Meta-Analysis , 2013, Neuropsychobiology.

[67]  A. Holland,et al.  Systematic review of high-intensity progressive resistance strength training of the lower limb compared with other intensities of strength training in older adults. , 2013, Archives of physical medicine and rehabilitation.

[68]  B. Ainsworth,et al.  International physical activity questionnaire: 12-country reliability and validity. , 2003, Medicine and science in sports and exercise.

[69]  F. Sofi,et al.  Physical activity and risk of cognitive decline: a meta‐analysis of prospective studies , 2011, Journal of internal medicine.

[70]  W. Mechelen,et al.  The Functional Effects of Physical Exercise Training in Frail Older People , 2008, Sports medicine.

[71]  Michael J Thun,et al.  Recreational physical activity and risk of Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[72]  M. Pallàs,et al.  Neurophysiological and epigenetic effects of physical exercise on the aging process , 2011, Ageing Research Reviews.

[73]  S. Lamb,et al.  Effect of exercise on depression severity in older people: systematic review and meta-analysis of randomised controlled trials , 2012, British Journal of Psychiatry.

[74]  P. Whincup,et al.  Physical Activity and Falls in Older Men: The Critical Role of Mobility Limitations , 2015, Medicine and science in sports and exercise.

[75]  Physical Activity Guidelines Advisory Committee report, 2008. To the Secretary of Health and Human Services. Part A: executive summary. , 2009, Nutrition reviews.

[76]  M. Rantz,et al.  Integrative Review of Physical Activity Intervention Research with Aging Adults , 2003, Journal of the American Geriatrics Society.

[77]  Q. Xue The frailty syndrome: definition and natural history. , 2011, Clinics in geriatric medicine.

[78]  N. Latham,et al.  Can progressive resistance strength training reduce physical disability in older adults? A meta-analysis study , 2011, Disability and rehabilitation.

[79]  H. Chen,et al.  Physical activity and the risk of Parkinson disease , 2005, Neurology.

[80]  G. Roos,et al.  Stand up for health—avoiding sedentary behaviour might lengthen your telomeres: secondary outcomes from a physical activity RCT in older people , 2014, British Journal of Sports Medicine.

[81]  Ben Godde,et al.  Human Neuroscience , 2009 .

[82]  J. Veerman,et al.  Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies , 2014, BMC Public Health.

[83]  Huong Q. Nguyen,et al.  Physical activity and older adults: expert consensus for a new research agenda. , 2011, The Gerontologist.

[84]  Michael E. Miller,et al.  Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. , 2014, JAMA.

[85]  D. Schoene,et al.  Dose-response relationship of resistance training in older adults: a meta-analysis. , 2010, Medicine and science in sports and exercise.

[86]  Eileen M. Crimmins,et al.  Lifespan and Healthspan: Past, Present, and Promise. , 2015, The Gerontologist.

[87]  R. McClure,et al.  Population-based interventions for the prevention of fall-related injuries in older people. , 2005, The Cochrane database of systematic reviews.

[88]  Catherine Sherrington,et al.  Older people's perspectives on participation in physical activity: a systematic review and thematic synthesis of qualitative literature , 2015, British Journal of Sports Medicine.

[89]  I. Aboderin,et al.  Compression of morbidity and active ageing: key priorities for public health policy in the 21st century. , 2002, Bulletin of the World Health Organization.

[90]  J. Chase Interventions to Increase Physical Activity Among Older Adults: A Meta-Analysis. , 2015, The Gerontologist.

[91]  A. Kalache,et al.  Active ageing: a policy framework. , 2003, Advances in gerontology = Uspekhi gerontologii.

[92]  Susan Quine,et al.  Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: a randomized controlled trial. , 2012, Journal of the American Medical Directors Association.

[93]  E. Scherder,et al.  Review of Effects of Physical Activity on Strength, Balance, Mobility and ADL Performance in Elderly Subjects with Dementia , 2010, Dementia and Geriatric Cognitive Disorders.

[94]  Jeffrey C. Valentine,et al.  Interventions to increase physical activity among aging adults: A meta-analysis , 2002, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[95]  Ronald C Petersen,et al.  Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. , 2011, Mayo Clinic proceedings.

[96]  R. Fielding,et al.  Exercise as an intervention for frailty. , 2011, Clinics in geriatric medicine.

[97]  T. Abe,et al.  Home‐based resistance training for older adults: A systematic review , 2014, Geriatrics & gerontology international.

[98]  M. Petrescu-Prahova,et al.  Implementation and Maintenance of a Community-Based Older Adult Physical Activity Program. , 2016, The Gerontologist.

[99]  Dawn A Skelton,et al.  How Sedentary are Older People? A Systematic Review of the Amount of Sedentary Behavior. , 2015, Journal of aging and physical activity.

[100]  Jeffrey R Stout,et al.  Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS) , 2014, Age and ageing.

[101]  M. Fiatarone Singh,et al.  The influence of physical activity on abdominal fat: a systematic review of the literature , 2006, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[102]  S. Leurgans,et al.  Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. , 2009, Archives of neurology.

[103]  J. Gerberding,et al.  Morbidity and Mortality Weekly Report , 2012 .

[104]  S. Thilarajah,et al.  Effectiveness of resistance training on muscle strength and physical function in people with Parkinson’s disease: a systematic review and meta-analysis , 2016, Clinical rehabilitation.

[105]  P. Bréchat,et al.  Health benefits of physical activity in older patients: a review , 2009, International journal of clinical practice.

[106]  E. McAuley,et al.  Exercise training increases size of hippocampus and improves memory , 2011, Proceedings of the National Academy of Sciences.

[107]  A. King,et al.  American College of Sports Medicine and the American Heart Association Physical Activity and Public Health in Older Adults. Recommendation From the , 2007 .

[108]  G. Salem,et al.  American College of Sports Medicine position stand. Exercise and physical activity for older adults. , 2009, Medicine and science in sports and exercise.

[109]  A. Dey World report on ageing and health , 2017, The Indian Journal of Medical Research.

[110]  S. Wannamethee,et al.  Physical Activity and the Prevention of Stroke , 1999, Journal of cardiovascular risk.

[111]  D M Buchner,et al.  Physical activity interventions targeting older adults. A critical review and recommendations. , 1998, American journal of preventive medicine.

[112]  Albert Gollhofer,et al.  Comparison of Traditional and Recent Approaches in the Promotion of Balance and Strength in Older Adults , 2011, Sports medicine.

[113]  Kristine Yaffe,et al.  Potential for primary prevention of Alzheimer's disease: an analysis of population-based data , 2014, The Lancet Neurology.

[114]  A. Farmer,et al.  Resistance Exercise Versus Aerobic Exercise for Type 2 Diabetes: A Systematic Review and Meta-Analysis , 2014, Sports Medicine.

[115]  Judy Kruger,et al.  Trends in strength training - United States, 1998-2004 , 2006 .

[116]  Chris Rissel,et al.  The impact of a home-based walking programme on falls in older people: the Easy Steps randomised controlled trial. , 2015, Age and ageing.

[117]  E. Rimm,et al.  A prospective study of weight training and risk of type 2 diabetes mellitus in men. , 2012, Archives of internal medicine.

[118]  S B Roberts,et al.  Exercise training and nutritional supplementation for physical frailty in very elderly people. , 1994, The New England journal of medicine.