Gold Catalyzed Decarboxylative Cross-Coupling of Iodoarenes.

This report details a decarboxylative cross-coupling of (hetero)aryl carboxylates with iodoarenes in the presence of a gold cata-lyst (>25 examples, up to 96% yield). This reaction is site specific, which overcomes prior limitations associated with gold cat-alyzed oxidative coupling reactions. The reactivity of the (hetero)aryl carboxylate correlates qualitatively to the field effect pa-rameter (Fortho). Reactions with isolated gold complexes and DFT calculations support a mechanism proceeding through oxida-tive addition at a gold(I) cation with decarboxylation being viable at either gold(I) or silver(I) species.

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