Rare Syringyl Acylated Flavonol Glycosides from the Aerial Parts of Leonurus japonicus Houtt

Five new syringyl acylated flavonol glycosides, named leonurusoides A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Compounds 1−6 showed triglyceride (TG) accumulation inhibitory effects in free fatty acid-induced HepG2 cells.

[1]  Jian-shuang Jiang,et al.  Hepatoprotective glycosides from Leonurus japonicus Houtt. , 2012, Carbohydrate research.

[2]  S. Kang,et al.  Labdane Diterpenes and Flavonoids from Leonurus japonicus , 2010 .

[3]  Qin Li,et al.  [Chemical constituents and antitumor activity on leukemia K562 cell of Leonurus heterophyllus]. , 2009, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[4]  Yi Zhang,et al.  Bioactive Constituents from Chinese Natural Medicines. XXV. New Flavonol Bisdesmosides, Sarmenosides I, II, III, and IV, with Hepatoprotective Activity from Sedum sarmentosum (Crassulaceae) , 2007 .

[5]  Yi Zhang,et al.  Bioactive Constituents from Chinese Natural Medicines. Part 22. Absolute Structures of New Megastigmane Glycosides, Sedumosides E1 (I), E2, E3 (II), F1, F2, and G, from Sedum sarmentosum (Crassulaceae). , 2007 .

[6]  C. Che,et al.  A new labdane diterpene from Leonurus heterophyllus , 2006, Journal of Asian natural products research.

[7]  M. Alonso-amelot,et al.  Labdane diterpenes from Leonurus japonicus leaves. , 2006, Phytochemistry.

[8]  Cai Xiao-han.  Studies on chemical constituents of Leonurus japonicus , 2006 .

[9]  H. Otsuka,et al.  New bis-spirolabdane-type diterpenoids from Leonurus heterophyllus Sw. , 2005, Chemical & pharmaceutical bulletin.

[10]  H. Otsuka,et al.  New labdane-type diterpenoids from Leonurus heterophyllus SW. , 2005, Chemical & pharmaceutical bulletin.

[11]  Xian Li,et al.  Note: A new flavonoside from Leonurus heterophyllus , 2005, Journal of Asian natural products research.