Biobased production of alkanes and alkenes through metabolic engineering of microorganisms

[1]  V. Siewers,et al.  Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories , 2016, Nature Communications.

[2]  J. Keasling,et al.  Engineering Cellular Metabolism , 2016, Cell.

[3]  George M Church,et al.  Genetically encoded sensors enable real-time observation of metabolite production , 2016, Proceedings of the National Academy of Sciences.

[4]  J. Keasling,et al.  Whole‐cell biocatalytic and de novo production of alkanes from free fatty acids in Saccharomyces cerevisiae , 2016, Biotechnology and bioengineering.

[5]  J. Nielsen,et al.  Advancing metabolic engineering through systems biology of industrial microorganisms. , 2015, Current opinion in biotechnology.

[6]  Wei Huang,et al.  Discovery of a Family of Desaturase-Like Enzymes for 1-Alkene Biosynthesis , 2015 .

[7]  Huimin Zhao,et al.  Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid synthase in E. coli. , 2015, Molecular bioSystems.

[8]  A. Mukhopadhyay Tolerance engineering in bacteria for the production of advanced biofuels and chemicals. , 2015, Trends in microbiology.

[9]  Dong-Yup Lee,et al.  Combinatorial metabolic engineering of Saccharomyces cerevisiae for terminal alkene production , 2015, bioRxiv.

[10]  A. Dennig,et al.  Oxidative Decarboxylation of Short-Chain Fatty Acids to 1-Alkenes. , 2015, Angewandte Chemie.

[11]  Xiaoming Tan,et al.  Genetically assembled fluorescent biosensor for in situ detection of bio-synthesized alkanes , 2015, Scientific Reports.

[12]  J. Nielsen,et al.  Long-chain alkane production by the yeast Saccharomyces cerevisiae. , 2015, Biotechnology and bioengineering.

[13]  Qian Liu,et al.  Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. , 2015, Metabolic engineering.

[14]  A. Krivoruchko,et al.  Microbial acetyl-CoA metabolism and metabolic engineering. , 2015, Metabolic engineering.

[15]  N. D. Da Silva,et al.  Overproduction and secretion of free fatty acids through disrupted neutral lipid recycle in Saccharomyces cerevisiae. , 2015, Metabolic engineering.

[16]  Aditya M. Kunjapur,et al.  Microbial Engineering for Aldehyde Synthesis , 2015, Applied and Environmental Microbiology.

[17]  Jamie H. D. Cate,et al.  Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase , 2014, Proceedings of the National Academy of Sciences.

[18]  G. Rimmelzwaan,et al.  An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines , 2014, Microbial Cell Factories.

[19]  Jens Nielsen,et al.  Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast , 2014, mBio.

[20]  K. Benjamin,et al.  Engineering Acetyl Coenzyme A Supply: Functional Expression of a Bacterial Pyruvate Dehydrogenase Complex in the Cytosol of Saccharomyces cerevisiae , 2014, mBio.

[21]  Qiong Wu,et al.  A seawater-based open and continuous process for polyhydroxyalkanoates production by recombinant Halomonas campaniensis LS21 grown in mixed substrates , 2014, Biotechnology for Biofuels.

[22]  Jens Nielsen,et al.  Improved production of fatty acid ethyl esters in Saccharomyces cerevisiae through up-regulation of the ethanol degradation pathway and expression of the heterologous phosphoketolase pathway , 2014, Microbial Cell Factories.

[23]  Christopher A. Voigt,et al.  Realizing the potential of synthetic biology , 2014, Nature Reviews Molecular Cell Biology.

[24]  Jens Nielsen,et al.  Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae. , 2014, Metabolic engineering.

[25]  Lei Chen,et al.  Engineering biofuel tolerance in non-native producing microorganisms. , 2014, Biotechnology advances.

[26]  Wei Zhang,et al.  Hydrogen peroxide-independent production of α-alkenes by OleTJE P450 fatty acid decarboxylase , 2014, Biotechnology for Biofuels.

[27]  Jian Zhang,et al.  Helically agitated mixing in dry dilute acid pretreatment enhances the bioconversion of corn stover into ethanol , 2014, Biotechnology for Biofuels.

[28]  J. Keasling,et al.  Engineering dynamic pathway regulation using stress-response promoters , 2013, Nature Biotechnology.

[29]  E. Marsh,et al.  Aldehyde Decarbonylases: Enigmatic Enzymes of Hydrocarbon Biosynthesis. , 2013, ACS catalysis.

[30]  Y. Choi,et al.  Microbial production of short-chain alkanes , 2013, Nature.

[31]  Jens Nielsen,et al.  Economic and environmental impacts of microbial biodiesel , 2013, Nature Biotechnology.

[32]  Binbin Chen,et al.  Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance , 2013, Biotechnology for Biofuels.

[33]  Nigel S Scrutton,et al.  Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase , 2013, Chembiochem : a European journal of chemical biology.

[34]  Xuefeng Lu,et al.  Engineering cyanobacteria to improve photosynthetic production of alka(e)nes , 2013, Biotechnology for Biofuels.

[35]  Rob Lee,et al.  Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli , 2013, Proceedings of the National Academy of Sciences.

[36]  M. Chang,et al.  Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae , 2013, Biotechnology for Biofuels.

[37]  L. Chai,et al.  Characterization and genomic analysis of kraft lignin biodegradation by the beta-proteobacterium Cupriavidus basilensis B-8 , 2013, Biotechnology for Biofuels.

[38]  Patrik R. Jones,et al.  Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities , 2012, Proceedings of the National Academy of Sciences.

[39]  C. Krebs,et al.  Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases. , 2012, Biochemistry.

[40]  Y. Jang,et al.  Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches. , 2012, Biotechnology advances.

[41]  T. Fricaux,et al.  An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis , 2012, Proceedings of the National Academy of Sciences.

[42]  J. Keasling,et al.  Microbial engineering for the production of advanced biofuels , 2012, Nature.

[43]  J. Napier,et al.  Reconstitution of Plant Alkane Biosynthesis in Yeast Demonstrates That Arabidopsis ECERIFERUM1 and ECERIFERUM3 Are Core Components of a Very-Long-Chain Alkane Synthesis Complex[C][W] , 2012, Plant Cell.

[44]  Jens Nielsen,et al.  Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production , 2012, Biotechnology for Biofuels.

[45]  S. Baker,et al.  A versatile toolkit for high throughput functional genomics with Trichoderma reesei , 2012, Biotechnology for Biofuels.

[46]  Yi He,et al.  Whole‐cell bacterial bioreporter for actively searching and sensing of alkanes and oil spills , 2011, Microbial biotechnology.

[47]  M. Dunlop Engineering microbes for tolerance to next-generation biofuels , 2011, Biotechnology for biofuels.

[48]  T. Bobik,et al.  Coproduction of Acetaldehyde and Hydrogen during Glucose Fermentation by Escherichia coli , 2011, Applied and Environmental Microbiology.

[49]  Brian F. Pfleger,et al.  Modular Synthase-Encoding Gene Involved in α-Olefin Biosynthesis in Synechococcus sp. Strain PCC 7002 , 2011, Applied and Environmental Microbiology.

[50]  D. Roby,et al.  Overexpression of Arabidopsis ECERIFERUM1 Promotes Wax Very-Long-Chain Alkane Biosynthesis and Influences Plant Response to Biotic and Abiotic Stresses1[W] , 2011, Plant Physiology.

[51]  M. Himmel,et al.  In planta expression of A. cellulolyticus Cel5A endocellulase reduces cell wall recalcitrance in tobacco and maize , 2011, Biotechnology for biofuels.

[52]  L. Wackett,et al.  Purification and Characterization of OleA from Xanthomonas campestris and Demonstration of a Non-decarboxylative Claisen Condensation Reaction* , 2011, The Journal of Biological Chemistry.

[53]  B. Shen,et al.  Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. , 2011, Journal of natural products.

[54]  Andreas Schirmer,et al.  Terminal Olefin (1-Alkene) Biosynthesis by a Novel P450 Fatty Acid Decarboxylase from Jeotgalicoccus Species , 2011, Applied and Environmental Microbiology.

[55]  L. Wackett,et al.  Cloning, purification, crystallization and preliminary X-ray diffraction of the OleC protein from Stenotrophomonas maltophilia involved in head-to-head hydrocarbon biosynthesis. , 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

[56]  A. Schirmer,et al.  Microbial Biosynthesis of Alkanes , 2010, Science.

[57]  K. A. Hunt,et al.  Structure, Function, and Insights into the Biosynthesis of a Head-to-Head Hydrocarbon in Shewanella oneidensis Strain MR-1 , 2010, Applied and Environmental Microbiology.

[58]  L. Wackett,et al.  Widespread Head-to-Head Hydrocarbon Biosynthesis in Bacteria and Role of OleA , 2010, Applied and Environmental Microbiology.

[59]  J. Keasling,et al.  Genes Involved in Long-Chain Alkene Biosynthesis in Micrococcus luteus , 2009, Applied and Environmental Microbiology.

[60]  L. Wackett Metabolic engineering , 2009, Nature biotechnology.

[61]  C. Lan,et al.  Enhancement of lipid production using biochemical, genetic and transcription factor engineering approaches. , 2009, Journal of biotechnology.

[62]  Yajun Yan,et al.  Engineering metabolic systems for production of advanced fuels , 2009, Journal of Industrial Microbiology & Biotechnology.

[63]  R. Jetter,et al.  Plant surface lipid biosynthetic pathways and their utility for metabolic engineering of waxes and hydrocarbon biofuels. , 2008, The Plant journal : for cell and molecular biology.

[64]  Marilyn J Aardema,et al.  Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies. , 2002, Mutation research.

[65]  Y. Kissin CHEMICAL MECHANISMS OF CATALYTIC CRACKING OVER SOLID ACIDIC CATALYSTS: ALKANES AND ALKENES , 2001 .

[66]  J. R. van der Meer,et al.  Development and characterization of a whole-cell bioluminescent sensor for bioavailable middle-chain alkanes in contaminated groundwater samples , 1997, Applied and environmental microbiology.

[67]  B. Poolman,et al.  Mechanisms of membrane toxicity of hydrocarbons. , 1995, Microbiological reviews.

[68]  J. Oró,et al.  Identification of Fatty Acids and Aliphatic Hydrocarbons in Sarcina lutea by Gas Chromatography and Combined Gas Chromatography-Mass Spectrometry , 1967, Journal of bacteriology.

[69]  P. Albro,et al.  LIPIDS OF SARCINA LUTEA. II. HYDROCARBON CONTENT OF THE LIPID EXTRACTS. , 1964, Journal of bacteriology.

[70]  Justin Schwartz Engineering , 1929, Nature.

[71]  Haiying Yu,et al.  Improving alkane synthesis in Escherichia coli via metabolic engineering , 2015, Applied Microbiology and Biotechnology.

[72]  L. Wackett,et al.  Hydrocarbon Biosynthesis in Microorganisms , 2015 .

[73]  Jens Nielsen,et al.  Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism. , 2013, Metabolic engineering.

[74]  G. J. Blomquist,et al.  Ecological, behavioral, and biochemical aspects of insect hydrocarbons. , 2005, Annual review of entomology.

[75]  P. Albro,et al.  The biochemistry of long-chain, nonisoprenoid hydrocarbons. I. Characterization of the hydrocarbons of Sarcina lutea and the isolation of possible intermediates of biosynthesis. , 1969, Biochemistry.