Genome-wide association study as a method to analyze the genome architecture in polygenic diseases, with the example of multiple sclerosis

[1]  V. Martinelli,et al.  Genetic burden of common variants in progressive and bout-onset multiple sclerosis , 2014, Multiple sclerosis.

[2]  J. Oksenberg.  Decoding multiple sclerosis: an update on genomics and future directions , 2013, Expert review of neurotherapeutics.

[3]  M. Pirinen,et al.  Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis , 2013, Nature Genetics.

[4]  Miles Parkes,et al.  Genetic insights into common pathways and complex relationships among immune-mediated diseases , 2013, Nature Reviews Genetics.

[5]  Reinhard Schneider,et al.  Unraveling genomic variation from next generation sequencing data , 2013, BioData Mining.

[6]  Jason H. Moore,et al.  Chapter 11: Genome-Wide Association Studies , 2012, PLoS Comput. Biol..

[7]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[8]  Calliope A. Dendrou,et al.  TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis , 2012, Nature.

[9]  O. Favorova,et al.  A Polygenic Approach to the Study 
of Polygenic Diseases , 2012, Acta naturae.

[10]  Adam Kiezun,et al.  Exome sequencing and the genetic basis of complex traits , 2012, Nature Genetics.

[11]  A. Alcina,et al.  Genome-Wide Association Study of Multiple Sclerosis Confirms a Novel Locus at 5p13.1 , 2012, PloS one.

[12]  G. Stewart,et al.  A genome-wide association study in progressive multiple sclerosis , 2012, Multiple sclerosis.

[13]  A. Marian.  Molecular genetic studies of complex phenotypes. , 2012, Translational research : the journal of laboratory and clinical medicine.

[14]  P. Visscher,et al.  Five years of GWAS discovery. , 2012, American journal of human genetics.

[15]  A. Janssens,et al.  Perspectives on the Use of Multiple Sclerosis Risk Genes for Prediction , 2011, PloS one.

[16]  P. D. de Bakker,et al.  Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci , 2011, Annals of neurology.

[17]  Simon C. Potter,et al.  Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis , 2011, Nature.

[18]  Ludwig Kappos,et al.  Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data , 2011, Genome Medicine.

[19]  F. Holsboer,et al.  Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis , 2010, Journal of Neuroimmunology.

[20]  L. Liang,et al.  Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis , 2010, Nature Genetics.

[21]  O. Kulakova,et al.  Multiple sclerosis as a polygenic disease: An update , 2010, Russian Journal of Genetics.

[22]  S. Gabriel,et al.  Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. , 2010, American journal of human genetics.

[23]  Ludwig Kappos,et al.  Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci , 2009, Nature Genetics.

[24]  Pablo Moscato,et al.  Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 , 2009, Nature Genetics.

[25]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[26]  Michael R. Johnson,et al.  Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. , 2009, Human molecular genetics.

[27]  David E. Anderson,et al.  Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses1 , 2009, The Journal of Immunology.

[28]  D. Craig,et al.  Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms , 2008, PloS one.

[29]  M. R. Mickey,et al.  Multiple sclerosis: association with HL-A3. , 2008, Tissue antigens.

[30]  M. McCarthy,et al.  Genome-wide association studies for complex traits: consensus, uncertainty and challenges , 2008, Nature Reviews Genetics.

[31]  P. Donnelly,et al.  Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants , 2007, Nature Genetics.

[32]  K. Sirotkin,et al.  The NCBI dbGaP database of genotypes and phenotypes , 2007, Nature Genetics.

[33]  H. Harbo,et al.  Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis , 2007, Nature Genetics.

[34]  Silke Schmidt,et al.  Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis , 2007, Nature Genetics.

[35]  S. Gabriel,et al.  Risk alleles for multiple sclerosis identified by a genomewide study. , 2007, The New England journal of medicine.

[36]  A. Alcina,et al.  IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility , 2007, Journal of Neurology.

[37]  W. L. Benedict,et al.  Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.

[38]  M. Daly,et al.  A high-density screen for linkage in multiple sclerosis. , 2005, American journal of human genetics.

[39]  J. Kurtzke.  Epidemiology and etiology of multiple sclerosis. , 2005, Physical medicine and rehabilitation clinics of North America.

[40]  P. Kovanen,et al.  New approaches to investigating heterogeneity in complex traits , 2003, Journal of medical genetics.

[41]  M. A. Kelly,et al.  Genetic susceptibility to multiple sclerosis: detection of polymorphic nucleotides and an intron in the 3' untranslated region of the major histocompatibility complex class II transactivator gene. , 2001, Human immunology.

[42]  W. Mcdonald,et al.  B-LYMPHOCYTE ALLOANTIGENS ASSOCIATED WITH MULTIPLE SCLEROSIS , 1976, The Lancet.

[43]  J. Barrett,et al.  How next-generation sequencing is transforming complex disease genetics. , 2013, Trends in genetics : TIG.

[44]  J. Stockman,et al.  Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study , 2009 .

[45]  C. Lindgren,et al.  •Australo-Anglo-American Spondylitis Consortium (TASC), et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 2007 Nov; 39(11):1329-37. * Member of the consortium and T2D analysis subgroup. PMID: 17952073. , 2007 .