The FACT-targeted drug CBL0137 enhances the effects of rituximab to inhibit B-cell non-Hodgkin’s lymphoma tumor growth by promoting apoptosis and autophagy
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Juan Wang | Jian-zhong Wu | Jifeng Feng | Kening Li | Rong Ma | Xiao Ma | Yuxin Du | Y-F Teng | Tongde Du | Yuxin Ma | Weiyan Tang | Jian-qiu Wu | Yan Lv | Jianzhong Wu
[1] Eutteum Jeong,et al. The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3 , 2022, Autophagy.
[2] OUP accepted manuscript , 2022, Nucleic Acids Research.
[3] K. Bhakat,et al. The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy. , 2021, DNA repair.
[4] K. Bhakat,et al. Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation. , 2021, Cancer letters.
[5] J. Pettitt,et al. Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma , 2021, Clinical Cancer Research.
[6] A. Rosenwald,et al. Rituximab plus high-dose chemotherapy (MegaCHOEP) or conventional chemotherapy (CHOEP-14) in young, high-risk patients with aggressive B-cell lymphoma: 10-year follow-up of a randomised, open-label, phase 3 trial. , 2021, The Lancet. Haematology.
[7] A. Marczak,et al. Two Faces of Autophagy in the Struggle against Cancer , 2021, International journal of molecular sciences.
[8] Ruikun Hu,et al. Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish. , 2021, Journal of genetics and genomics = Yi chuan xue bao.
[9] M. Taheri,et al. The emerging role of non-coding RNAs in the regulation of PI3K/AKT pathway in the carcinogenesis process. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[10] Anurag K. Singh,et al. Stimulation of an anti-tumor immune response with “chromatin-damaging” therapy , 2021, Cancer Immunology, Immunotherapy.
[11] G. Chamberlain,et al. Induction , 2015, A Warning for Fair Women.
[12] Yujie Tang,et al. Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 , 2020, Cell Death & Disease.
[13] G. Stark,et al. CBL0137 increases the targeting efficacy of Rovalpituzumab tesirine against tumour-initiating cells in small cell lung cancer , 2020, British Journal of Cancer.
[14] W. Stevens,et al. Molecular Genetics of Relapsed Diffuse Large B-Cell Lymphoma: Insight into Mechanisms of Therapy Resistance , 2020, Cancers.
[15] K. Huntoon,et al. The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma. , 2020, Cancer letters.
[16] M. Komatsu,et al. Monitoring Autophagy Flux and Activity: Principles and Applications , 2020, BioEssays : news and reviews in molecular, cellular and developmental biology.
[17] D. Scott,et al. Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma. , 2020, Cancer discovery.
[18] F. Speleman,et al. PRL3 enhances T cell acute lymphoblastic leukemia growth through suppressing T cell signaling pathways and apoptosis , 2020, Leukemia.
[19] Ali F. Alsulami,et al. Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target , 2020, Haematologica.
[20] John G Doench,et al. MYC Controls the Epstein-Barr Virus Lytic Switch. , 2020, Molecular cell.
[21] W. El-Deiry,et al. Targeting apoptosis in cancer therapy , 2020, Nature Reviews Clinical Oncology.
[22] H. Maecker,et al. IMPAIRED IMMUNE HEALTH IN SURVIVORS OF DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL): A LARGE POPULATION‐BASED STUDY , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[23] Dongqing Wei,et al. Identification of chlorprothixene as a potential drug that induces apoptosis and autophagic cell death in acute myeloid leukemia cells , 2020, The FEBS journal.
[24] U. Kees,et al. Potent antileukemic activity of curaxin CBL0137 against MLL‐rearranged leukemia , 2020, International journal of cancer.
[25] Sina Salari,et al. C-Myc inhibition sensitizes pre-B ALL cells to the anti-tumor effect of vincristine by altering apoptosis and autophagy: Proposing a probable mechanism of action for 10058-F4. , 2019, European journal of pharmacology.
[26] M. Perales,et al. Modern management of relapsed and refractory aggressive B-cell lymphoma: A perspective on the current treatment landscape and patient selection for CAR T-cell therapy. , 2019, Blood reviews.
[27] A. Feldman,et al. Coactivation of NF-κB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion. , 2019, Blood.
[28] I. Ng,et al. Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression , 2019, Gut.
[29] Xiaodong Zhao,et al. The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells , 2019, International journal of cancer.
[30] Wei-Lin Jin,et al. Curaxin CBL0137 Exerts Anticancer Activity via Diverse Mechanisms , 2018, Front. Oncol..
[31] B. Manavathi,et al. Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer , 2018, Cell Death & Disease.
[32] E. Baehrecke,et al. Life, death and autophagy , 2018, Nature Cell Biology.
[33] Jiajun Fan,et al. Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E , 2018, Front. Immunol..
[34] Stefano Monti,et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes , 2018, Nature Medicine.
[35] G. Stark,et al. The FACT inhibitor CBL0137 Synergizes with Cisplatin in Small-Cell Lung Cancer by Increasing NOTCH1 Expression and Targeting Tumor-Initiating Cells. , 2018, Cancer research.
[36] Maozhi Hu,et al. w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway , 2017, Autophagy.
[37] S. Nakajima,et al. SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. , 2017, Cancer research.
[38] A. Gudkov,et al. Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma , 2016, Neuro-oncology.
[39] A. Gudkov,et al. Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas. , 2016, Cancer research.
[40] Wei Li,et al. Blockage of SSRP1/Ets-1/Pim-3 signalling enhances chemosensitivity of nasopharyngeal carcinoma to docetaxel in vitro. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[41] Qiulian Wu,et al. Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models. , 2016, Cancer research.
[42] Chunxia Xiao,et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. , 2016, Free radical biology & medicine.
[43] Chien-Ju Lin,et al. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration. , 2016, Cancer letters.
[44] F. Speleman,et al. Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma , 2015, Science Translational Medicine.
[45] Feng Wang,et al. Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway , 2015, International journal of immunopathology and pharmacology.
[46] P. Schumacker,et al. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? , 2014, Nature Reviews Cancer.
[47] B. Bonavida. Postulated mechanisms of resistance of B-cell non-Hodgkin lymphoma to rituximab treatment regimens: strategies to overcome resistance. , 2014, Seminars in oncology.
[48] Iannis Aifantis,et al. Notch signaling: switching an oncogene to a tumor suppressor. , 2014, Blood.
[49] Zhihua Yang,et al. Protection of neurons from high glucose-induced injury by deletion of MAD2B , 2014, Journal of cellular and molecular medicine.
[50] J. Puyal,et al. A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis , 2014, Autophagy.
[51] W. Zong,et al. Chinese a Nti鄄 Cancer a Ssociation , 2022 .
[52] F. Minutolo,et al. Curaxins: A New Family of Non‐genotoxic Multitargeted Anticancer Agents , 2011, ChemMedChem.
[53] A. Komar,et al. Curaxins: Anticancer Compounds That Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT , 2011, Science Translational Medicine.
[54] J. Cowell,et al. Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease. , 2011, Blood.
[55] Z. Elazar,et al. Regulation of autophagy by ROS: physiology and pathology. , 2011, Trends in biochemical sciences.
[56] B. Sobhian,et al. Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin , 2011, Molecular Cancer.
[57] W. Yung,et al. Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. , 2010, Neuro-oncology.
[58] Jia Liu,et al. Cyclin E Is Stabilized in Response to Replication Fork Barriers Leading to Prolonged S Phase Arrest* , 2009, The Journal of Biological Chemistry.
[59] E. White,et al. The Double-Edged Sword of Autophagy Modulation in Cancer , 2009, Clinical Cancer Research.
[60] P. Kaldis,et al. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms , 2009, Oncogene.
[61] J. León,et al. Inhibition of cell differentiation: A critical mechanism for MYC-mediated carcinogenesis? , 2009, Cell cycle.
[62] Yufang Shi,et al. Apoptosis signaling pathways and lymphocyte homeostasis , 2007, Cell Research.
[63] A. Ng,et al. Diffuse large B-cell lymphoma. , 2007, Seminars in radiation oncology.
[64] G. Evan,et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. , 2007, The Journal of clinical investigation.
[65] Jinho Kim,et al. YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases. , 2006, Cancer research.
[66] I. Landais,et al. Coupling caspase cleavage and ubiquitin–proteasome-dependent degradation of SSRP1 during apoptosis , 2006, Cell Death and Differentiation.
[67] D. Reinberg,et al. Facts about FACT and transcript elongation through chromatin. , 2004, Current opinion in genetics & development.
[68] F. Levi-Schaffer,et al. Role of reactive oxygen species (ROS) in apoptosis induction , 2000, Apoptosis.
[69] Mitchell R. Smith. Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance , 2003, Oncogene.
[70] Hilde van der Togt,et al. Publisher's Note , 2003, J. Netw. Comput. Appl..
[71] J. Massagué,et al. Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage , 2002, Nature.
[72] J. Massagué,et al. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. , 2002, Nature.
[73] Cynthia A. Schandl,et al. Major DNA Fragmentation Is a Late Event in Apoptosis , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[74] T. Hunter,et al. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age , 1994, Cell.
[75] J. Puyal,et al. Title : A critical role of autophagy in antileukemia / lymphoma effects of APO 866 , an inhibitor of NAD biosynthesis , 2022 .