Enhancing immune response to HIV infection using MPC-based treatment scheduling

icant drop in deaths due to opportunistic infections, it Using recently developed models of the interaction of the human immune system and the Human Immunodeficiency Virus (HIV), we have developed a model predictive control (MPC) based method for determining optimal treatment interruption schedules. These schedules use interruptions of Highly Active AntiRetroviral Therapy (HAART) to induce immune control of the virus without the need for continued treatment, as suggested by the models. In this paper, we discuss the medical motivation for this work, introduce the MPC-based method and show simulation results, and discuss future work necessary to implement the method.

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