Use of monitoring levels of soluble forms of cytokeratin 18 in the urine of patients with superficial bladder cancer following intravesical Ad-IFNα/Syn3 treatment in a Phase l study

[1]  C. Dinney,et al.  Phase I trial of intravesical recombinant adenovirus mediated interferon-α2b formulated in Syn3 for Bacillus Calmette-Guérin failures in nonmuscle invasive bladder cancer. , 2013, The Journal of urology.

[2]  C. Dinney,et al.  Direct cytotoxicity produced by adenoviral-mediated interferon α gene transfer in interferon-resistant cancer cells involves ER stress and caspase 4 activation , 2011, Cancer Gene Therapy.

[3]  W. Benedict,et al.  Direct gene transfer of adenoviral-mediated interferon α into human bladder cancer cells but not the bystander factors produced induces endoplasmic reticulum stress-related cytotoxicity , 2011, Cancer Gene Therapy.

[4]  W. Benedict,et al.  Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon α: possible use as a surrogate marker 1 , 2009, Cancer Gene Therapy.

[5]  E. D. de Vries,et al.  Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer. , 2008, Neoplasia.

[6]  W. Benedict,et al.  Conditioned medium from Ad-IFN-α-infected bladder cancer and normal urothelial cells is cytotoxic to cancer cells but not normal cells: further evidence for a strong bystander effect , 2008, Cancer Gene Therapy.

[7]  S. Linder Cytokeratin Markers Come of Age , 2007, Tumor Biology.

[8]  W. Benedict,et al.  Adenoviral-mediated interferon α overcomes resistance to the interferon protein in various cancer types and has marked bystander effects , 2007, Cancer Gene Therapy.

[9]  C. Dinney,et al.  Efficacy of a single intravesical treatment with Ad-IFN/Syn 3 is dependent on dose and urine IFN concentration obtained: implications for clinical investigation , 2006, Cancer Gene Therapy.

[10]  R. Millikan,et al.  Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Interferon-Induced Apoptosis in Human Bladder Cancer Cells , 2004, Cancer Research.

[11]  C. Dinney,et al.  Intravesical Ad-IFNα Causes Marked Regression of Human Bladder Cancer Growing Orthotopically in Nude Mice and Overcomes Resistance to IFN-α Protein , 2004 .

[12]  C. Dinney,et al.  Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.