Towards a holistic and solution-oriented monitoring of chemical status of European water bodies: how to support the EU strategy for a non-toxic environment?

[1]  Rolf Altenburger,et al.  Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays. , 2014, Environmental science & technology.

[2]  Hiroshi Ohba,et al.  Isolation and identification of non-chlorinated phenylbenzotriazole (non-ClPBTA)-type mutagens in the Ho River in Shizuoka Prefecture, Japan. , 2006, Mutation research.

[3]  Jin Hwan Do,et al.  Clustering approaches to identifying gene expression patterns from DNA microarray data. , 2008, Molecules and cells.

[4]  Pim E. G. Leonards,et al.  Identification strategy for unknown pollutants using high-resolution mass spectrometry: Androgen-disrupting compounds identified through effect-directed analysis , 2011, Analytical and bioanalytical chemistry.

[5]  Timo Hamers,et al.  Challenges in effect-directed analysis with a focus on biological samples , 2015 .

[6]  E. Simon,et al.  Screening and risk management solutions for steroidal estrogens in surface and wastewater , 2018 .

[7]  W. Brack.  Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures? , 2003, Analytical and bioanalytical chemistry.

[8]  H. Hollert,et al.  Toward Streamlined Identification of Dioxin-like Compounds in Environmental Samples through Integration of Suspension Bioassay. , 2017, Environmental science & technology.

[9]  M. Lamoree,et al.  Masking effect of anti-androgens on androgenic activity in European river sediment unveiled by effect-directed analysis , 2009, Analytical and bioanalytical chemistry.

[10]  Thomas Backhaus,et al.  Predictive environmental risk assessment of chemical mixtures: a conceptual framework. , 2012, Environmental science & technology.

[11]  T. Christiansen,et al.  European waters assessment of status and pressures 2018. , 2012 .

[12]  Edward J. Perkins,et al.  The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment , 2017, Toxicological sciences : an official journal of the Society of Toxicology.

[13]  R. Triebskorn,et al.  Efficiency of advanced wastewater treatment technologies for the reduction of hormonal activity in effluents and connected surface water bodies by means of vitellogenin analyses in rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta f. fario) , 2015, Environmental Sciences Europe.

[14]  G. Bidoglio,et al.  EU-wide survey of polar organic persistent pollutants in European river waters. , 2009, Environmental pollution.

[15]  M. Grote,et al.  Organic chemicals jeopardize the health of freshwater ecosystems on the continental scale , 2014, Proceedings of the National Academy of Sciences.

[16]  Helmut Segner,et al.  The SOLUTIONS project: challenges and responses for present and future emerging pollutants in land and water resources management. , 2015, The Science of the total environment.

[17]  Florian Leese,et al.  Potenzial genetischer Methoden für das Biomonitoring der Wasserrahmenrichtlinie , 2017, WASSERWIRTSCHAFT.

[18]  Emma L. Schymanski,et al.  Open Science for Identifying "Known Unknown" Chemicals. , 2017, Environmental science & technology.

[19]  Timo Hamers,et al.  Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring. , 2016, Water research.

[20]  Philippe Esling,et al.  Predicting the Ecological Quality Status of Marine Environments from eDNA Metabarcoding Data Using Supervised Machine Learning. , 2017, Environmental science & technology.

[21]  M. Liess,et al.  Culmination of Low-Dose Pesticide Effects , 2013, Environmental science & technology.

[22]  S. Ping.  STOCKHOLM CONVENTION and Persistent Organic Pollutants (POPs) , 2005 .

[23]  E. Simon,et al.  Effect-based tools for monitoring estrogenic mixtures: Evaluation of five in vitro bioassays. , 2017, Water research.

[24]  Rolf Altenburger,et al.  Pollution-Induced Community Tolerance To Diagnose Hazardous Chemicals in Multiple Contaminated Aquatic Systems. , 2015, Environmental science & technology.

[25]  T. Braunbeck,et al.  Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine — a mass balance approach using in vitro methods and chemical analysis , 2008, Environmental science and pollution research international.

[26]  Martin Krauss,et al.  Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect-based analysis. , 2017, The Science of the total environment.

[27]  Martin Krauss,et al.  Linking mutagenic activity to micropollutant concentrations in wastewater samples by partial least square regression and subsequent identification of variables. , 2015, Chemosphere.

[28]  T. Ternes,et al.  Advancing Biological Wastewater Treatment: Extended Anaerobic Conditions Enhance the Removal of Endocrine and Dioxin-like Activities. , 2016, Environmental science & technology.

[29]  Ingvar Eide,et al.  Toxicological evaluation of complex mixtures: fingerprinting and multivariate analysis. , 2004, Environmental toxicology and pharmacology.

[30]  Martin Krauss,et al.  Identification of Unknown Antiandrogenic Compounds in Surface Waters by Effect-Directed Analysis (EDA) Using a Parallel Fractionation Approach. , 2018, Environmental science & technology.

[31]  É. Fetter,et al.  Knotting nets: Molecular junctions of interconnecting endocrine axes identified by application of the adverse outcome pathway concept , 2018, Environmental toxicology and chemistry.

[32]  pflegebildung , 2019, ProCare.

[33]  H. Köhler,et al.  SchussenAktivplus: reduction of micropollutants and of potentially pathogenic bacteria for further water quality improvement of the river Schussen, a tributary of Lake Constance, Germany , 2013, Environmental Sciences Europe.

[34]  Timo Hamers,et al.  Continuous fraction collection of gas chromatographic separations with parallel mass spectrometric detection applied to cell-based bioactivity analysis. , 2017, Talanta.

[35]  Emma L. Schymanski,et al.  Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go? , 2017, Environmental science & technology.

[36]  M. Junghans,et al.  How a complete pesticide screening changes the assessment of surface water quality. , 2014, Environmental science & technology.

[37]  Rolf Altenburger,et al.  Mixture effects in samples of multiple contaminants - An inter-laboratory study with manifold bioassays. , 2018, Environment international.

[38]  W. Brack,et al.  Identification of Mutagenic Aromatic Amines in River Samples with Industrial Wastewater Impact. , 2017, Environmental science & technology.

[39]  Kristian Fog Nielsen,et al.  Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking , 2016, Nature Biotechnology.

[40]  M. Liess,et al.  Analyzing effects of pesticides on invertebrate communities in streams , 2005, Environmental toxicology and chemistry.

[41]  Roman Ashauer,et al.  Post-ozonation in a municipal wastewater treatment plant improves water quality in the receiving stream , 2016, Environmental Sciences Europe.

[42]  Helmut Segner,et al.  Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management. , 2015, The Science of the total environment.

[43]  G. A. Burton,et al.  In situ microbiota distinguished primary anthropogenic stressor in freshwater sediments. , 2018, Environmental pollution.

[44]  Michael G. Weller,et al.  A Unifying Review of Bioassay-Guided Fractionation, Effect-Directed Analysis and Related Techniques , 2012, Sensors.

[45]  Benno Schwikowski,et al.  From the exposome to mechanistic understanding of chemical-induced adverse effects. , 2017, Environment international.

[46]  W. Brack,et al.  Characterization and risk assessment of seasonal and weather dynamics in organic pollutant mixtures from discharge of a separate sewer system. , 2018, Water research.

[47]  Rolf Altenburger,et al.  Pollution‐induced community tolerance as a measure of species interaction in toxicity assessment , 2008 .

[48]  Werner Brack,et al.  Read‐Across Prediction of the Acute Toxicity of Organic Compounds toward the Water Flea Daphnia magna , 2013, Molecular informatics.

[49]  Rolf Altenburger,et al.  Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water. , 2017, Water research.

[50]  B. Grung,et al.  Toxicological evaluation of complex mixtures by pattern recognition: correlating chemical fingerprints to mutagenicity. , 2002, Environmental health perspectives.

[51]  David M. Reif,et al.  In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project , 2009, Environmental health perspectives.

[52]  Ralph Kühne,et al.  Quantitative read-across for predicting the acute fish toxicity of organic compounds. , 2011, Environmental science & technology.

[53]  Matthias Liess,et al.  Relative sensitivity distribution of aquatic invertebrates to organic and metal compounds , 2004, Environmental toxicology and chemistry.

[54]  J. Giesy,et al.  In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents. , 2013, Water research.

[55]  Megan P. O’Connor,et al.  Natural Gas Residual Fluids: Sources, Endpoints, and Organic Chemical Composition after Centralized Waste Treatment in Pennsylvania. , 2015, Environmental science & technology.

[56]  W. Brack,et al.  Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis. , 2017, Environmental pollution.

[57]  Werner Brack,et al.  Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect‐directed analysis , 2012, Environmental toxicology and chemistry.

[58]  Gregor Knopp,et al.  Integrated Evaluation Concept to Assess the Efficacy of Advanced Wastewater Treatment Processes for the Elimination of Micropollutants and Pathogens. , 2017, Environmental science & technology.

[59]  Ron van der Oost,et al.  SIMONI (Smart Integrated Monitoring) as a novel bioanalytical strategy for water quality assessment: Part I–model design and effect‐based trigger values , 2017, Environmental toxicology and chemistry.

[60]  Valeria Dulio,et al.  Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive , 2018 .

[61]  D. Dix,et al.  The ToxCast program for prioritizing toxicity testing of environmental chemicals. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[62]  W. Brack,et al.  Effect-directed identification of oxygen and sulfur heterocycles as major polycyclic aromatic cytochrome P4501A-inducers in a contaminated sediment. , 2003, Environmental science & technology.

[63]  L Mark Hewitt,et al.  Analytical methods in environmental effects-directed investigations of effluents. , 2005, Mutation research.

[64]  Timo Hamers,et al.  Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive. , 2018, The Science of the total environment.

[65]  J. Lewtas,et al.  Bioassay-directed chemical analysis in environmental research. , 1986, Analytical chemistry.

[66]  W. Thomas,et al.  Dramatic Shifts in Benthic Microbial Eukaryote Communities following the Deepwater Horizon Oil Spill , 2012, PloS one.

[67]  M. Rosenbaum,et al.  Status quo report on wastewater treatment plant, receiving water's biocoenosis and quality as basis for evaluation of large-scale ozonation process. , 2018, Water science and technology : a journal of the International Association on Water Pollution Research.

[68]  Anthony A Chariton,et al.  Metabarcoding of benthic eukaryote communities predicts the ecological condition of estuaries. , 2015, Environmental pollution.

[69]  Marja Lamoree,et al.  Effects‐directed analysis (EDA) and toxicity identification evaluation (TIE): Complementary but different approaches for diagnosing causes of environmental toxicity , 2013, Environmental toxicology and chemistry.

[70]  Rolf Altenburger,et al.  Micropollutants in European rivers: A mode of action survey to support the development of effect‐based tools for water monitoring , 2016, Environmental toxicology and chemistry.

[71]  Thomas Letzel,et al.  Non-target screening with high-resolution mass spectrometry: critical review using a collaborative trial on water analysis , 2015, Analytical and Bioanalytical Chemistry.

[72]  J. Hollender,et al.  Micropollutant-induced tolerance of in situ periphyton: Establishing causality in wastewater-impacted streams. , 2017, Water research.

[73]  T. Backhaus,et al.  Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: Mixtures composed of similarly acting chemicals , 2000 .

[74]  Youzhong Liu,et al.  MetICA: independent component analysis for high-resolution mass-spectrometry based non-targeted metabolomics , 2016, BMC Bioinformatics.

[75]  Wibke Busch,et al.  Screening of Pesticide and Biocide Patterns As Risk Drivers in Sediments of Major European River Mouths: Ubiquitous or River Basin-Specific Contamination? , 2018, Environmental science & technology.

[76]  Sharon Munn,et al.  Advancing the adverse outcome pathway framework—An international horizon scanning approach , 2017, Environmental toxicology and chemistry.

[77]  Antony J. Williams,et al.  The CompTox Chemistry Dashboard: a community data resource for environmental chemistry , 2017, Journal of Cheminformatics.

[78]  Javier R. Viguri,et al.  DNAqua-Net: Developing new genetic tools for bioassessment and monitoring of aquatic ecosystems in Europe , 2016 .

[79]  Tobias Schulze,et al.  Effect-directed analysis supporting monitoring of aquatic environments--An in-depth overview. , 2016, The Science of the total environment.

[80]  Leo Posthuma,et al.  Definition and applications of a versatile chemical pollution footprint methodology. , 2014, Environmental science & technology.

[81]  R. Altenburger,et al.  Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams. , 2017, The Science of the total environment.

[82]  Mario Carere,et al.  In vitro bioassays to screen for endocrine active pharmaceuticals in surface and waste waters. , 2015, Journal of pharmaceutical and biomedical analysis.

[83]  Martin Krauss,et al.  Multicriteria approach to select polyaromatic river mutagen candidates. , 2015, Environmental science & technology.

[84]  Kevin V Thomas,et al.  An assessment of in vitro androgenic activity and the identification of environmental androgens in United Kingdom estuaries , 2002, Environmental toxicology and chemistry.

[85]  W. Brack,et al.  Solid-phase extraction as sample preparation of water samples for cell-based and other in vitro bioassays. , 2018, Environmental science. Processes & impacts.

[86]  Jens C. Otte,et al.  Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos , 2018, Environmental Science and Pollution Research.

[87]  Tobias Porsbring,et al.  The European technical report on aquatic effect-based monitoring tools under the water framework directive , 2015, Environmental Sciences Europe.

[88]  Werner Brack,et al.  Effect‐directed analysis of mutagens and ethoxyresorufin‐O‐deethylase inducers in aquatic sediments , 2005, Environmental toxicology and chemistry.

[89]  Jaroslav Slobodnik,et al.  Emerging pollutants in the EU: 10 years of NORMAN in support of environmental policies and regulations , 2018, Environmental Sciences Europe.

[90]  M. Hauschild,et al.  Chemical footprint method for improved communication of freshwater ecotoxicity impacts in the context of ecological limits. , 2014, Environmental science & technology.

[91]  M. Liess,et al.  Indication of pesticide effects and recolonization in streams. , 2018, The Science of the total environment.

[92]  P. Usseglio-Polatera,et al.  Assessing anthropogenic pressures on streams: A random forest approach based on benthic diatom communities. , 2017, The Science of the total environment.

[93]  M. Hecker,et al.  Characterisation of transcriptional responses to dioxins and dioxin-like contaminants in roach (Rutilus rutilus) using whole transcriptome analysis. , 2016, The Science of the total environment.

[94]  Serenella Sala,et al.  Chemical footprint: A methodological framework for bridging life cycle assessment and planetary boundaries for chemical pollution , 2013, Integrated environmental assessment and management.

[95]  M. Waldock,et al.  Characterization of estrogenic compounds in water samples collected from United Kingdom estuaries , 2001, Environmental toxicology and chemistry.

[96]  J. B. Sprague.  Measurement of pollutant toxicity to fish. II. Utilizing and applying bioassay results , 1970 .

[97]  R. Liu,et al.  Removal of novel antiandrogens identified in biological effluents of domestic wastewater by activated carbon. , 2017, The Science of the total environment.

[98]  W. Brack,et al.  Effect-directed analysis (EDA) of Danube River water sample receiving untreated municipal wastewater from Novi Sad, Serbia. , 2018, The Science of the total environment.

[99]  C. Tyler,et al.  An Assessment of the Model of Concentration Addition for Predicting the Estrogenic Activity of Chemical Mixtures in Wastewater Treatment Works Effluents , 2005, Environmental health perspectives.

[100]  M. Liess,et al.  Pesticides reduce regional biodiversity of stream invertebrates , 2013, Proceedings of the National Academy of Sciences.

[101]  Daniel L Villeneuve,et al.  Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment , 2010, Environmental toxicology and chemistry.

[102]  S. Loewe,et al.  Über Kombinationswirkungen , 1926, Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie.

[103]  Emma L. Schymanski,et al.  Strategies to characterize polar organic contamination in wastewater: exploring the capability of high resolution mass spectrometry. , 2014, Environmental science & technology.

[104]  Martin Krauss,et al.  Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling. , 2015, Environmental science & technology.

[105]  M. Loos,et al.  Quantitative target and systematic non-target analysis of polar organic micro-pollutants along the river Rhine using high-resolution mass-spectrometry--Identification of unknown sources and compounds. , 2015, Water research.

[106]  Martin Krauss,et al.  Mutagenicity in Surface Waters: Synergistic Effects of Carboline Alkaloids and Aromatic Amines. , 2017, Environmental science & technology.

[107]  D. de Zwart,et al.  Complex mixture toxicity for single and multiple species: Proposed methodologies , 2005, Environmental toxicology and chemistry.

[108]  H. Blanck,et al.  Pollution-induced community tolerance (PICT): towards an ecologically relevant risk assessment of chemicals in aquatic systems , 2016 .

[109]  R. Altenburger,et al.  Bioassay-Directed Identification of Organic Toxicants in River Sediment in the Industrial Region of Bitterfeld (Germany)—A Contribution to Hazard Assessment , 1999, Archives of environmental contamination and toxicology.

[110]  G. A. Burton,et al.  Prospective mixture risk assessment and management prioritizations for river catchments with diverse land uses , 2018, Environmental toxicology and chemistry.

[111]  M. Hecker,et al.  Toward understanding the impacts of sediment contamination on a native fish species: transcriptional effects, EROD activity, and biliary PAH metabolites , 2016, Environmental Sciences Europe.

[112]  Frederic D L Leusch,et al.  Effect-based trigger values for in vitro bioassays: Reading across from existing water quality guideline values. , 2015, Water research.

[113]  K. Tollefsen,et al.  Effect-directed identification of naphthenic acids as important in vitro xeno-estrogens and anti-androgens in North sea offshore produced water discharges. , 2009, Environmental science & technology.

[114]  Jian Ma,et al.  A network-assisted co-clustering algorithm to discover cancer subtypes based on gene expression , 2014, BMC Bioinformatics.

[115]  Diana H. Wall,et al.  Distributional (In)Congruence of Biodiversity-Ecosystem Functioning , 2012 .

[116]  Werner Brack,et al.  How to confirm identified toxicants in effect-directed analysis , 2008, Analytical and bioanalytical chemistry.