Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants

controls. The design called for any variant with P 1% frequency) for association with MI; none met the prespecified threshold for replication testing (P 65 years old, 5-10% of new MIs occur in younger patients and these events are associated with substantially greater heritability 5,6 . Thus, early-onset MI is a promising phenotype for genetic mapping. Genome-wide association studies (GWASs) of common SNPs have been reported for MI and coronary artery disease 1-3,7 , with each study finding common SNPs on chromosome 9p21.3 associated with MI or coronary artery disease. In addition to 9p21.3, these papers proposed at least eight other loci as harboring SNPs associated with coronary artery disease. Some of these loci await definitive replication, but even if all were valid they would explain a small fraction of the risk of MI.