The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.

[1]  M. Colonna,et al.  Phosphatidylinositol 3-Kinase Activation Is Required To Form the NKG2D Immunological Synapse , 2007, Molecular and Cellular Biology.

[2]  Jayajit Das,et al.  The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. , 2007, Immunity.

[3]  Rajat Varma,et al.  T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. , 2006, Immunity.

[4]  A. Kupfer Signaling in the immunological synapse: defining the optimal size. , 2006, Immunity.

[5]  A. Shaw,et al.  Immune synapses in T-cell activation. , 2006, Current opinion in immunology.

[6]  K. Mossman,et al.  Altered TCR Signaling from Geometrically Repatterned Immunological Synapses , 2005, Science.

[7]  Takashi Saito,et al.  Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76 , 2005, Nature Immunology.

[8]  Rajat Varma,et al.  Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling , 2005, The Journal of experimental medicine.

[9]  D. Fremont,et al.  Costimulation through NKG2D Enhances Murine CD8+ CTL Function: Similarities and Differences between NKG2D and CD28 Costimulation1 , 2005, The Journal of Immunology.

[10]  Morgan Huse,et al.  Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity , 2005, Nature.

[11]  M. Alegre,et al.  Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  P. Marrack,et al.  Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Arup K Chakraborty,et al.  The Immunological Synapse Balances T Cell Receptor Signaling and Degradation , 2003, Science.

[14]  Mark M Davis,et al.  Continuous T cell receptor signaling required for synapse maintenance and full effector potential , 2003, Nature Immunology.

[15]  I. Jang,et al.  Negative regulation of TCR signaling and T-cell activation by selective protein degradation. , 2003, Current opinion in immunology.

[16]  G. Bismuth,et al.  Imaging antigen-induced PI3K activation in T cells , 2002, Nature Immunology.

[17]  Mark M. Davis,et al.  Direct observation of ligand recognition by T cells , 2002, Nature.

[18]  D. Cantrell,et al.  Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse , 2002, Nature Immunology.

[19]  D. Zaller,et al.  Staging and resetting T cell activation in SMACs , 2002, Nature Immunology.

[20]  Michael Loran Dustin,et al.  T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.

[21]  G. Griffiths,et al.  The immunological synapse of CTL contains a secretory domain and membrane bridges. , 2001, Immunity.

[22]  Bernard Malissen,et al.  The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations , 2000, Nature Immunology.

[23]  T. Kitamura,et al.  Plat-E: an efficient and stable system for transient packaging of retroviruses , 2000, Gene Therapy.

[24]  Jun Wu,et al.  An activating immunoreceptor complex formed by NKG2D and DAP10. , 1999, Science.

[25]  R. Germain,et al.  Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. , 1999, Journal of immunology.

[26]  D. Fremont,et al.  High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. , 1998, Immunity.

[27]  Colin R. F. Monks,et al.  Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.

[28]  P. Allen,et al.  Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation. , 1998, Science.

[29]  P. Allen,et al.  TCR Transgenic Mice in Which Usage of Transgenic α- and β-Chains Is Highly Dependent on the Level of Selecting Ligand , 1998, The Journal of Immunology.

[30]  R. Germain,et al.  Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. , 1998, Journal of immunology.

[31]  Christoph Wülfing,et al.  Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal , 1997, The Journal of experimental medicine.

[32]  P. Allen,et al.  Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands , 1996, The Journal of experimental medicine.

[33]  Y. Chien,et al.  A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. , 1996, Immunity.

[34]  A. Lanzavecchia,et al.  Serial triggering of many T-cell receptors by a few peptide–MHC complexes , 1995, Nature.

[35]  L. Samelson,et al.  Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists , 1995, Science.

[36]  Paul M. Allen,et al.  Partial T cell signaling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy , 1994, Cell.

[37]  M. Davis,et al.  Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). , 1994, Journal of immunology.

[38]  R. G. Anderson,et al.  Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation , 1993, The Journal of cell biology.

[39]  A. Kong,et al.  p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain. , 1992, Molecular and cellular biology.

[40]  W. Paul,et al.  The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice , 1992, The Journal of experimental medicine.

[41]  Emil R. Unanue,et al.  Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation , 1990, Nature.

[42]  S. Jameson,et al.  Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor , 1989, Nature.

[43]  S. Dzik,et al.  The immunological synapse: A molecular machine controlling T cell activation , 2000 .

[44]  C. Slaughter,et al.  The 21- and 23-kD forms of TCR zeta are generated by specific ITAM phosphorylations. , 2000, Nature immunology.

[45]  P. Allen,et al.  TCR transgenic mice in which usage of transgenic alpha- and beta-chains is highly dependent on the level of selecting ligand. , 1998, Journal of immunology.

[46]  A. Lanzavecchia,et al.  The duration of antigenic stimulation determines the fate of naive and effector T cells. , 1998, Immunity.