Safety of emulsifiers in fats and oils

Consumers have come to expect many foods that can be served with minimum effort. Such convenience foods frequently require the use of emulsifiers in their formulations. Emulsifiers enable fatty and aqueous phases to be combined. Various emulsifiers have been developed to meet specific needs and have been judged adequately safe for their intended uses. Safety evaluation programs may include both feeding studies and metabolic studies. Feeding studies establish the levels at which a compound can be fed to experimental animals with no detectable ill effects. From this information, it is possible to estimate quantities that may be consumed safely by humans. Metabolic studies tell how a compound is handled by the body—whether it is burned for energy, stored, or excreted. The choice of studies to use in evaluating a specific compound depends upon the chemical nature of the compound, its similarity to familiar materials, and its intended use. Studies carried out with polysorbates and with monoglycerides are reviewed to illustrate these points and to show how safety testing programs yield the information needed for making sound safety judgments.

[1]  G. Dasher Surface activity of naturally occurring emulsifiers. , 1952, Science.

[2]  M. Gibaldi,et al.  Mechanisms of surfactant effects on drug absorption. , 1970, Journal of pharmaceutical sciences.

[3]  A. Hofmann Micellar Solubilization of Fatty Acids and Monoglycerides by Bile Salt Solutions , 1961, Nature.

[4]  H. Schoolman,et al.  The effect of emulsifying agents (tween 60 and span 60) on the gastrointestinal tract. , 1953, The American journal of digestive diseases.

[5]  E. Eagle,et al.  The oral toxicity and pathology of polyoxyethylene derivatives in rats and hamsters. , 1956 .

[6]  B. Chow,et al.  Effects of basal diets on the response of rats to certain dietary non-ionic surface-active agents. , 1953, The Journal of nutrition.

[7]  P. Gedigk,et al.  SPECIFICATIONS FOR THE IDENTITY AND PURITY OF FOOD ADDITIVES AND THEIR TOXICOLOGICAL EVALUATION: EMULSIFIERS, STABILIZERS, BLEACHING AND MATURING AGENTS. , 1964, World Health Organization technical report series.

[8]  Sur un nouveau type de lipolyse ‘in vitro’ une lipolyse “Génératrice de glycérol” , 1951 .

[9]  R. S. Harris,et al.  COMPARISON OF THE NUTRITIVE VALUES OF MONO‐, DI‐, AND TRIGLYCERIDES BY A MODIFIED PAIR‐FEEDING TECHNIQUEa,b , 1954 .

[10]  F. Mattson,et al.  Intermediates formed during the digestion of triglycerides. , 1952, The Journal of nutrition.

[11]  A. A. Nelson,et al.  Chronic oral toxicities of four stearic acid emulsifiers. , 1959, Toxicology and applied pharmacology.

[12]  G. Hübscher,et al.  Monoglyceride transacylase of rat-intestinal mucosa , 1963 .

[13]  R. Wissler,et al.  Effects of Polyoxyethylene Sorbitan Monolaurate (Tween 20) upon Gastrointestinal Iron Absorption in Hamsters.∗ , 1954, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[14]  A. Frazer,et al.  The formation of mono- and di-glycerides during the hydrolysis of triglyceride by pancreatic lipase. , 1945, The Biochemical journal.

[15]  V. P. Skipski,et al.  The absorption in the rat of a 1,3-dioleyl-2-deuteriostearyl glyceride-C14 and a 1-monodeuteriostearyl glyceride-C14. , 1959, Archives of biochemistry and biophysics.

[16]  F. Mattson,et al.  THE DIGESTION AND ABSORPTION OF TRIGLYCERIDES. , 1964, The Journal of biological chemistry.

[17]  P. L. Harris,et al.  Molecularly distilled monoglycerides. III. Nutritional studies on monoglycerides derived from cottonseed oil , 1951 .

[18]  F. Baur Analytical methodology for emulsifiers used in fatty foods: a review , 1973 .