Determination of Dechlorane Plus in serum from electronics dismantling workers in South China.

Previous studies have reported high serum concentrations of polybrominated diphenyl ethers in residents of an electronic waste (e-waste) dismantling site in Guiyu town, South China. In this study, serum levels of Dechlorane Plus (DP), a chlorinated flame retardant of growing concern, were measured in residents of this region, and compared to those of a matched cohort from a nearby region in Haojiang, where fishing is the dominant industry. DP was detected in all the serum samples, with concentrations ranging from 7.8 to 465 ng/g lipid (median: 42.6 ng/g) and 0.93 to 50.5 ng/g lipid (median: 13.7 ng/g) in Guiyu and Haojiang, respectively. The Pearson's correlation coefficient between DP and decabromodiphenyl ether showed a positive relationship in Guiyu (r = 0.931, p < 0.01), but no correlation in Haojiang (r = 0.321, p = 0.34). The average anti-DP fractional abundances (f(anti) ratio) were 0.58 +/- 0.11 and 0.64 +/- 0.05 for Guiyu and Haojiang, respectively (p < 0.01). Tentatively identified dechlorination product ([-Cl + H]) was found in 19/40 serum samples (11/20 for Guiyu, 8/20 for Haojiang). These results suggest that the Guiyu and Haojiang cohorts experienced different dominant exposure routes. It is also possible that DP could bioaccumulate in a stereoselective manner, and undergo dechlorination metabolism. To the best of our knowledge, this is the first study to report DP levels in human serum. Further studies are needed to confirm the results of this study.

[1]  Heather M Stapleton,et al.  Debromination of polybrominated diphenyl ether congeners BDE 99 and BDE 183 in the intestinal tract of the common carp (Cyprinus carpio). , 2004, Environmental science & technology.

[2]  C. D. de Wit.  An overview of brominated flame retardants in the environment. , 2002, Chemosphere.

[3]  M. Eens,et al.  Accumulation, tissue-specific distribution and debromination of decabromodiphenyl ether (BDE 209) in European starlings (Sturnus vulgaris). , 2007, Environmental pollution.

[4]  E. Braekevelt,et al.  Bioaccumulation, biotransformation, and biochemical effects of brominated diphenyl ethers in juvenile lake trout (Salvelinus namaycush). , 2004, Environmental science & technology.

[5]  Yi-Fan Li,et al.  Levels and isomer profiles of dechlorane plus in Chinese air. , 2008, Environmental science & technology.

[6]  Francis L Martin,et al.  Exposure of electronics dismantling workers to polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in South China. , 2007, Environmental science & technology.

[7]  Jiping Zhu,et al.  Identification and determination of hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO) in residential indoor air and dust: a previously unreported halogenated flame retardant in the environment. , 2008, Environmental science & technology.

[8]  R. Renner.  Government Watch: In U.S., flame retardants will be voluntarily phased out , 2004 .

[9]  L. Hovander,et al.  Identification of Hydroxylated PCB Metabolites and Other Phenolic Halogenated Pollutants in Human Blood Plasma , 2002, Archives of environmental contamination and toxicology.

[10]  C. Marvin,et al.  Isomers of dechlorane plus in Lake Winnipeg and Lake Ontario food webs. , 2007, Environmental science & technology.

[11]  R. Hites,et al.  Measurement of Polybrominated Diphenyl Ethers and Metabolites in Mouse Plasma after Exposure to a Commercial Pentabromodiphenyl Ether Mixture , 2007, Environmental health perspectives.

[12]  Jiping Zhu,et al.  Detection of dechlorane plus in residential indoor dust in the city of Ottawa, Canada. , 2007, Environmental science & technology.

[13]  R. Hites,et al.  Dechlorane plus and other flame retardants in tree bark from the northeastern United States. , 2008, Environmental science & technology.

[14]  Ed Sverko,et al.  Examination of isomer specific bioaccumulation parameters and potential in vivo hepatic metabolites of syn- and anti-Dechlorane Plus isomers in juvenile rainbow trout (Oncorhynchus mykiss). , 2008, Environmental science & technology.

[15]  R. Hites,et al.  Novel flame retardants, 1,2-bis(2,4,6-tribromophenoxy)ethane and 2,3,4,5,6-pentabromoethylbenzene, in United States' environmental samples. , 2005, Environmental science & technology.

[16]  C. Marvin,et al.  Brominated and chlorinated flame retardants in Lake Ontario, Canada, lake trout (Salvelinus namaycush) between 1979 and 2004 and possible influences of food‐web changes , 2009, Environmental toxicology and chemistry.

[17]  Guoying Sheng,et al.  Exposure to polybrominated diphenyl ethers among workers at an electronic waste dismantling region in Guangdong, China. , 2007, Environment international.

[18]  C. Marvin,et al.  Dechlorane plus and other flame retardants in a sediment core from Lake Ontario. , 2007, Environmental science & technology.

[19]  G. Marsh,et al.  Polybrominated Diphenyl Ethers (PBDEs) and Bioaccumulative Hydroxylated PBDE Metabolites in Young Humans from Managua, Nicaragua , 2007, Environmental health perspectives.

[20]  J. Huwe,et al.  Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male sprague-dawley rats following dietary exposure. , 2007, Environmental science & technology.

[21]  R. Letcher,et al.  Current-use flame retardants in the eggs of herring gulls (Larus argentatus) from the Laurentian Great Lakes. , 2007, Environmental science & technology.

[22]  R. Hites,et al.  Dechlorane plus, a chlorinated flame retardant, in the Great Lakes. , 2006, Environmental science & technology.

[23]  C. Marvin,et al.  Dechlorane plus levels in sediment of the lower Great Lakes. , 2008, Environmental science & technology.

[24]  G. Marsh,et al.  Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats. , 2005, Environmental science & technology.