Species- and cell type-specific requirements for cellular transformation.

[1]  C. Der,et al.  Distinct requirements for Ras oncogenesis in human versus mouse cells. , 2002, Genes & development.

[2]  Richard A. Ashmun,et al.  Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.

[3]  J. L. Bos,et al.  ras oncogenes in human cancer: a review. , 1989, Cancer research.

[4]  Joseph R. Nevins,et al.  A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells , 2004, Nature Cell Biology.

[5]  Channing J Der,et al.  Increasing complexity of Ras signaling , 1998, Oncogene.

[6]  R. Agami,et al.  The tumor-suppressive functions of the human INK4A locus. , 2003, Cancer cell.

[7]  W. Hahn,et al.  Identification of specific PP2A complexes involved in human cell transformation. , 2004, Cancer cell.

[8]  G. Peters,et al.  Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts , 2002, Molecular and Cellular Biology.

[9]  Wenyi Wei,et al.  Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts , 2001, Molecular and Cellular Biology.

[10]  W. Hahn,et al.  Modelling the molecular circuitry of cancer , 2002, Nature Reviews Cancer.

[11]  G. Peters,et al.  Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes. , 2003, Cancer cell.

[12]  T. Mizukami,et al.  Reconstitution of telomerase activity utilizing human catalytic subunit expressed in insect cells. , 2002, Biochemical and biophysical research communications.

[13]  L. Donehower,et al.  In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. , 1993, Oncogene.

[14]  P. Warne,et al.  Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras , 1997, Cell.

[15]  R. Sager Senescence as a mode of tumor suppression. , 1991, Environmental health perspectives.

[16]  Robert A. Weinberg,et al.  Comparative Biology of Mouse versus Human Cells: Modelling Human Cancer in Mice O P I N I O N , 2022 .

[17]  T. Urano,et al.  Ral‐GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. , 1996, The EMBO journal.

[18]  R. Newbold,et al.  Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens , 1982, Nature.

[19]  R. Wolthuis,et al.  Stimulation of gene induction and cell growth by the Ras effector Rlf , 1997, The EMBO journal.

[20]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[21]  V. Janssens,et al.  Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. , 2001, The Biochemical journal.

[22]  S. Oldham,et al.  Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[23]  T. Jacks,et al.  Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. , 2000, Genes & development.

[24]  A. Berns,et al.  Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice , 2001, Nature.

[25]  J. Pipas,et al.  Requirements for immortalization of primary mouse embryo fibroblasts probed with mutants bearing deletions in the 3' end of SV40 gene A. , 1988, Virology.

[26]  F. McCormick,et al.  The RB and p53 pathways in cancer. , 2002, Cancer cell.

[27]  J. Sedivy,et al.  Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. , 1999, Cancer research.

[28]  D. Carrasco,et al.  Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis , 2001, Nature.

[29]  J. Shay Telomerase in human development and cancer , 1997, Journal of cellular physiology.

[30]  S. Lowe,et al.  Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.

[31]  C. Der,et al.  Understanding Ras: 'it ain't over 'til it's over'. , 2000, Trends in cell biology.

[32]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.

[33]  William C Hahn,et al.  Rules for making human tumor cells. , 2002, The New England journal of medicine.

[34]  J. Hancock,et al.  Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase* , 1998, The Journal of Biological Chemistry.

[35]  Lisa Junker It Ain't Over 'Til It's Over , 2001 .

[36]  W. Hahn,et al.  Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. , 2001, Genes & development.

[37]  Robert A. Weinberg,et al.  Creation of human tumour cells with defined genetic elements , 1999, Nature.

[38]  H. Green,et al.  QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES , 1963, The Journal of cell biology.

[39]  J. Downward Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.

[40]  Charles J. Sherr,et al.  The INK4a/ARF network in tumour suppression , 2001, Nature Reviews Molecular Cell Biology.

[41]  Robert A. Weinberg,et al.  Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation , 2002, Molecular and Cellular Biology.

[42]  S. Benchimol,et al.  Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span , 1998, Current Biology.