Cellular events in protein tolerant inbred rats. I. The fate of thoracic duct lymphocytes and memory cells during tolerance induction to human serum albumin

(AS2 x AS)F1 hybrid rats were made completely or partially tolerant to an adjuvant challenge of human serum albumin (HSA) by prior treatment with fluid HSA (tolerogen). Single doses (10 μg to 200 mg) of fluid HSA failed to elicit a detectable immune response. However, rats made partially tolerant by repeated small doses (10 – 100 μg) synthesized significant quantities of antibody in response to the treatment.

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