Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity

[1]  M. Vieth,et al.  Crystal structure of human RIOK2 bound to a specific inhibitor , 2019, Open Biology.

[2]  Jin-jian Lu,et al.  Anticancer drug discovery from Chinese medicinal herbs , 2018, Chinese Medicine.

[3]  Jin-jian Lu,et al.  Downregulation of Cyclin B1 mediates nagilactone E‐induced G2 phase cell cycle arrest in non‐small cell lung cancer cells , 2018, European journal of pharmacology.

[4]  Y. Yamaguchi,et al.  Effect of nagilactone E on cell morphology and glucan biosynthesis in budding yeast Saccharomyces cerevisiae. , 2018, Fitoterapia.

[5]  R. West,et al.  GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma. , 2018, Cancer Research.

[6]  Emily M. Lee,et al.  Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry , 2018, Cell Discovery.

[7]  Xiuping Chen,et al.  New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect , 2018, Journal of Natural Medicines.

[8]  Jin-jian Lu,et al.  Norditerpenoids and Dinorditerpenoids from the Seeds of Podocarpus nagi as Cytotoxic Agents and Autophagy Inducers. , 2017, Journal of natural products.

[9]  A. Tan,et al.  Brusatol overcomes chemoresistance through inhibition of protein translation , 2017, Molecular carcinogenesis.

[10]  F. Gao,et al.  A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice. , 2016, Cardiovascular research.

[11]  Jin-jian Lu,et al.  Effects of alisol B 23-acetate on ovarian cancer cells: G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition. , 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[12]  Hong‐Lin Chen,et al.  High Expression of RIOK2 and NOB1 Predict Human Non-small Cell Lung Cancer Outcomes , 2016, Scientific Reports.

[13]  James Lee,et al.  Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis , 2015, Molecular & Cellular Proteomics.

[14]  D. Kingston,et al.  Antiproliferative Constituents of the Roots of Ethiopian Podocarpus falcatus and Structure Revision of 2α-Hydroxynagilactone F and Nagilactone I. , 2015, Journal of natural products.

[15]  J. T. Dunnen,et al.  Next generation sequencing technology: Advances and applications. , 2014, Biochimica et biophysica acta.

[16]  C. Thermes,et al.  Ten years of next-generation sequencing technology. , 2014, Trends in genetics : TIG.

[17]  Lirong Chen,et al.  Systems pharmacology strategies for anticancer drug discovery based on natural products. , 2014, Molecular bioSystems.

[18]  P. Clemons,et al.  Target identification and mechanism of action in chemical biology and drug discovery. , 2013, Nature chemical biology.

[19]  Olivier Elemento,et al.  Using transcriptome sequencing to identify mechanisms of drug action and resistance , 2011, Nature chemical biology.

[20]  Wenjiao Song,et al.  A metabolic alkene reporter for spatiotemporally controlled imaging of newly synthesized proteins in Mammalian cells. , 2010, ACS chemical biology.

[21]  A. Ciccodicola,et al.  Uncovering the Complexity of Transcriptomes with RNA-Seq , 2010, Journal of biomedicine & biotechnology.

[22]  W. Huber,et al.  which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets , 2011 .

[23]  Davis J. McCarthy,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[24]  Stephen W Michnick,et al.  The connectivity map , 2006, Nature chemical biology.

[25]  Paul A Clemons,et al.  The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease , 2006, Science.

[26]  J. Pelletier,et al.  Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles. , 2004, RNA.

[27]  A. Gingras,et al.  4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family* , 1998, The Journal of Biological Chemistry.

[28]  Ruben Abagyan,et al.  ICM—A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation , 1994, J. Comput. Chem..

[29]  Luis Carrasco,et al.  Enzymic and nonenzymic translocation by yeast polysomes. Site of action of a number of inhibitors. , 1977, Biochemistry.

[30]  L. Siminovitch,et al.  The molecular basis of emetine resistance in chinese hamster ovary cells: Alteration in the 40S ribosomal subunit , 1977, Cell.

[31]  M. Lubin,et al.  Cycloheximide: Aspects of Inhibition of Protein Synthesis in Mammalian Cells , 1964, Science.

[32]  Jin-jian Lu,et al.  Nagilactone E suppresses TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell lung cancer cells. , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[33]  Justin Lamb,et al.  The Connectivity Map: a new tool for biomedical research , 2007, Nature Reviews Cancer.