Development of a Multi-Array Pressure Sensor Module for Radial Artery Pulse Wave Measurement

This study proposes a new structure for a pressure sensor module that can reduce errors caused by measurement position and direction in noninvasive radial artery pulse wave measurement, which is used for physiological monitoring. We have proposed a structure for a multi-array pressure sensor with a hexagonal arrangement and polydimethylsiloxane that easily fits to the structure of the radial artery, and evaluated the characteristics and pulse wave measurement of the developed sensor by finite element method simulation, a push–pull gauge test, and an actual pulse wave measurement experiment. The developed sensor has a measuring area of 17.6 × 17.6 mm2 and a modular structure with the analog front end embedded on the printed circuit board. The finite element method simulation shows that the developed sensor responds linearly to external pressure. According to the push–pull gauge test results for each channel, there were differences between the channels caused by the unit sensor characteristics and fabrication process. However, the correction formula can minimize the differences and ensure the linearity, and root-mean-squared error is 0.267 kPa in calibrated output. Although additional experiments and considerations on inter-individual differences are required, the results suggested that the proposed multiarray sensor could be used as a radial arterial pulse wave sensor.

[1]  Effects of monolithic silicon postulated as an isotropic material on design of microstructures , 2000 .

[2]  Ali P. Gordon,et al.  Mechanical Property Optimization of FDM PLA in Shear with Multiple Objectives , 2015, JOM.

[3]  Daniel W. Jones,et al.  Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. , 2005, Hypertension.

[4]  A. Sinha,et al.  Incidence and predictors of radial artery occlusion after transradial coronary angioplasty: Doppler-guided follow-up study. , 2015, The Journal of invasive cardiology.

[5]  Robert D. Boehmer,et al.  Continuous, Real-Time, Noninvasive Monitor of Blood Pressure: Peňaz Methodology Applied to the Finger , 1987, Journal of Clinical Monitoring.

[6]  G. Gensini,et al.  Dynamic response of liquid-filled catheter systems for measurement of blood pressure: precision of measurements and reliability of the Pressure Recording Analytical Method with different disposable systems. , 2011, Journal of critical care.

[7]  M. C. Tracey,et al.  Mechanical characterization of bulk Sylgard 184 for microfluidics and microengineering , 2014 .

[8]  T. Schmitz-Rode,et al.  Comparison between radial artery tonometry pulse analyzer and pulsed-Doppler echocardiography derived hemodynamic parameters in cardiac surgery patients: a pilot study , 2017, PeerJ.

[9]  L. Geddes,et al.  Characterization of the oscillometric method for measuring indirect blood pressure , 2006, Annals of Biomedical Engineering.

[10]  PhD Maynard Ramsey III MD,et al.  Blood pressure monitoring: Automated oscillometric devices , 2005, Journal of Clinical Monitoring.

[11]  J. Rinehart,et al.  Impact of non invasive and beat-to-beat arterial pressure monitoring on intraoperative hemodynamic management , 2012, Journal of Clinical Monitoring and Computing.

[12]  D. Webb,et al.  Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis , 1998, Journal of hypertension.

[13]  John E. Dolbow,et al.  Effect of out-of-plane properties of a polyimide film on the stress fields in microelectronic structures , 1996 .

[14]  M. Band,et al.  Peripheral blood pressure measurement is as good as applanation tonometry at predicting ascending aortic blood pressure , 2003, Journal of hypertension.

[15]  K. Johnston,et al.  Predictors of radial artery size in patients undergoing cardiac catheterization: insights from the Good Radial Artery Size Prediction (GRASP) study. , 2012, The Canadian journal of cardiology.

[16]  A. Kankainen,et al.  The radial artery is larger than the ulnar. , 2003, The Annals of thoracic surgery.

[17]  Y. Chua,et al.  Factors Influencing Radial Artery Size , 2007, Asian cardiovascular & thoracic annals.

[18]  J. Nürnberger,et al.  Augmentation index is associated with cardiovascular risk , 2002, Journal of hypertension.

[19]  Berend E. Westerhof,et al.  Noninvasive continuous hemodynamic monitoring , 2012, Journal of Clinical Monitoring and Computing.

[20]  T. Timurkaynak,et al.  Angiographic evaluation of the radial artery diameter in patients who underwent coronary angiography or coronary intervention. , 2013, The Journal of invasive cardiology.

[21]  Denis Chemla,et al.  Clinical review: Interpretation of arterial pressure wave in shock states , 2005, Critical care.

[22]  Charles F Babbs,et al.  The origin of Korotkoff sounds and the accuracy of auscultatory blood pressure measurements. , 2015, Journal of the American Society of Hypertension : JASH.

[23]  J Melbin,et al.  Arterial tonometry: review and analysis. , 1983, Journal of biomechanics.

[24]  Sunil V. Rao,et al.  Radial artery diameter does not correlate with body mass index: A duplex ultrasound analysis of 1706 patients undergoing trans-radial catheterization at three experienced radial centers. , 2017, International journal of cardiology.

[25]  Pekka Kostiainen,et al.  Clinical assessment of a non-invasive wearable MEMS pressure sensor array for monitoring of arterial pulse waveform, heart rate and detection of atrial fibrillation , 2019, npj Digital Medicine.

[26]  Dongkai Shangguan,et al.  A new method to evaluate BGA pad cratering in lead-free soldering , 2008, 2008 58th Electronic Components and Technology Conference.

[27]  Karel H Wesseling,et al.  Finometer, finger pressure measurements with the possibility to reconstruct brachial pressure , 2003, Blood pressure monitoring.