Anatomic Clinical Trial Endpoints for Nonexudative Age-Related Macular Degeneration.

[1]  Sina Farsiu,et al.  Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration. , 2016, Ophthalmology.

[2]  G. Virgili,et al.  Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. , 2015, The Cochrane database of systematic reviews.

[3]  Christoph K. Hitzenberger,et al.  Identification of Drusen Characteristics in Age-Related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography , 2015, American journal of ophthalmology.

[4]  P. Rosenfeld,et al.  Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits. , 2015, Ophthalmic surgery, lasers & imaging retina.

[5]  P. Rosenfeld,et al.  Comparison of Geographic Atrophy Growth Rates Using Different Imaging Modalities in the COMPLETE Study. , 2015, Ophthalmic surgery, lasers & imaging retina.

[6]  D. Palanker,et al.  NONDAMAGING PHOTOTHERMAL THERAPY FOR THE RETINA: Initial Clinical Experience With Chronic Central Serous Retinopathy , 2015, Retina.

[7]  C. Luu,et al.  Nanosecond laser therapy reverses pathologic and molecular changes in age‐related macular degeneration without retinal damage , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  Jiayan Huang,et al.  Association of OCT-Derived Drusen Measurements with AMD-Associated Genotypic SNPs in the Amish Population , 2015, Journal of clinical medicine.

[9]  G. Ying,et al.  Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials. , 2015, Ophthalmology.

[10]  D. Rodger,et al.  Drusen and RPE atrophy automated quantification by optical coherence tomography in an elderly population , 2015, Eye.

[11]  R. Spaide.  COLOCALIZATION OF PSEUDODRUSEN AND SUBRETINAL DRUSENOID DEPOSITS USING HIGH-DENSITY EN FACE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY , 2014, Retina.

[12]  Lauren N Ayton,et al.  Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration. , 2014, Ophthalmology.

[13]  William J Feuer,et al.  Change in drusen area over time compared using spectral-domain optical coherence tomography and color fundus imaging. , 2014, Investigative ophthalmology & visual science.

[14]  Robert Tibshirani,et al.  Quantitative SD-OCT imaging biomarkers as indicators of age-related macular degeneration progression. , 2014, Investigative ophthalmology & visual science.

[15]  A. Merkur,et al.  Optical coherence tomography-based measurement of drusen load predicts development of advanced age-related macular degeneration. , 2014, American journal of ophthalmology.

[16]  Christian Simader,et al.  A longitudinal comparison of spectral-domain optical coherence tomography and fundus autofluorescence in geographic atrophy. , 2014, American journal of ophthalmology.

[17]  Danielle B. Gutierrez,et al.  Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium. , 2014, Investigative ophthalmology & visual science.

[18]  Felipe A Medeiros,et al.  Biomarkers and surrogate endpoints in glaucoma clinical trials , 2014, British Journal of Ophthalmology.

[19]  A. Vingrys,et al.  Nanosecond‐laser application in intermediate AMD: 12‐month results of fundus appearance and macular function , 2014, Clinical & experimental ophthalmology.

[20]  Steffen Schmitz-Valckenberg,et al.  Geographic atrophy: clinical features and potential therapeutic approaches. , 2014, Ophthalmology.

[21]  Daniel L Rubin,et al.  AN IMPROVED OPTICAL COHERENCE TOMOGRAPHY–DERIVED FUNDUS PROJECTION IMAGE FOR DRUSEN VISUALIZATION , 2014, Retina.

[22]  Kang Zhang,et al.  Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study. , 2014, Ophthalmology.

[23]  A. Bird,et al.  Geographic atrophy: a histopathological assessment. , 2014, JAMA ophthalmology.

[24]  E. Agrón,et al.  Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36. , 2014, JAMA ophthalmology.

[25]  P. Rosenfeld,et al.  OCT minimum intensity as a predictor of geographic atrophy enlargement. , 2014, Investigative ophthalmology & visual science.

[26]  S. Sadda,et al.  DRUSEN MEASUREMENTS COMPARISON BY FUNDUS PHOTOGRAPH MANUAL DELINEATION VERSUS OPTICAL COHERENCE TOMOGRAPHY RETINAL PIGMENT EPITHELIAL SEGMENTATION AUTOMATED ANALYSIS , 2014, Retina.

[27]  R. Dalal,et al.  SUBVISIBLE RETINAL LASER THERAPY: Titration Algorithm and Tissue Response , 2014, Retina.

[28]  Kang Zhang,et al.  Change in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degeneration. , 2013, Ophthalmic surgery, lasers & imaging retina.

[29]  Glenn J Jaffe,et al.  Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials. , 2015, Ophthalmology.

[30]  D. Rubin,et al.  Semi-automatic geographic atrophy segmentation for SD-OCT images. , 2013, Biomedical optics express.

[31]  Pearse A Keane,et al.  Optical coherence tomography-based observation of the natural history of drusenoid lesion in eyes with dry age-related macular degeneration. , 2013, Ophthalmology.

[32]  E. Chew,et al.  Circularity index as a risk factor for progression of geographic atrophy. , 2013, Ophthalmology.

[33]  Usha Chakravarthy,et al.  Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial , 2013, The Lancet.

[34]  G. Jaffe,et al.  SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY–DETERMINED MORPHOLOGIC PREDICTORS OF AGE-RELATED MACULAR DEGENERATION–ASSOCIATED GEOGRAPHIC ATROPHY PROGRESSION , 2013, Retina.

[35]  Danielle B. Gutierrez,et al.  Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. , 2013, Investigative ophthalmology & visual science.

[36]  Giovanni Gregori,et al.  Predicting the progression of geographic atrophy in age-related macular degeneration with SD-OCT en face imaging of the outer retina. , 2013, Ophthalmic surgery, lasers & imaging retina.

[37]  Tanya S. Glaser,et al.  Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial. , 2013, Investigative ophthalmology & visual science.

[38]  T. Ach,et al.  Disappearance of central confluent soft drusen following vitrectomy and ILM peeling , 2013, Eye.

[39]  William J Feuer,et al.  Comparison of drusen area detected by spectral domain optical coherence tomography and color fundus imaging. , 2013, Investigative ophthalmology & visual science.

[40]  Usha Chakravarthy,et al.  Clinical classification of age-related macular degeneration. , 2013, Ophthalmology.

[41]  William J Feuer,et al.  Comparison of geographic atrophy measurements from the OCT fundus image and the sub-RPE slab image. , 2013, Ophthalmic surgery, lasers & imaging retina.

[42]  L. Singerman,et al.  INVESTIGATION OF ORAL FENRETINIDE FOR TREATMENT OF GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION , 2013, Retina.

[43]  C. Curcio,et al.  SUBRETINAL DRUSENOID DEPOSITS IN NON-NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Morphology, Prevalence, Topography, and Biogenesis Model , 2013, Retina.

[44]  William J Feuer,et al.  Square root transformation of geographic atrophy area measurements to eliminate dependence of growth rates on baseline lesion measurements: a reanalysis of age-related eye disease study report no. 26. , 2013, JAMA ophthalmology.

[45]  G. Guyatt,et al.  Use and interpretation of composite end points in orthopaedic trials. , 2012, The Journal of bone and joint surgery. American volume.

[46]  D. Pascolini,et al.  Global estimates of visual impairment: 2010 , 2011, British Journal of Ophthalmology.

[47]  Glenn J Jaffe,et al.  Semiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degeneration. , 2011, Investigative ophthalmology & visual science.

[48]  B. Lujan,et al.  Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degeneration. , 2011, Ophthalmology.

[49]  Christian Ahlers,et al.  Performance of automated drusen detection by polarization-sensitive optical coherence tomography. , 2011, Investigative ophthalmology & visual science.

[50]  P. Rosenfeld,et al.  Current Clinical Trials in Dry AMD and the Definition of Appropriate Clinical Outcome Measures , 2011, Seminars in ophthalmology.

[51]  U. Schmidt-Erfurth,et al.  Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy , 2011, Acta ophthalmologica.

[52]  William J Feuer,et al.  Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography. , 2011, Ophthalmology.

[53]  B. Lujan,et al.  Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography. , 2011, Ophthalmology.

[54]  George A. Williams,et al.  Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration , 2011, Proceedings of the National Academy of Sciences.

[55]  P. Rosenfeld,et al.  Characteristics of patients losing vision after 2 years of monthly dosing in the phase III ranibizumab clinical trials. , 2011, Ophthalmology.

[56]  Christian Simader,et al.  A systematic comparison of spectral-domain optical coherence tomography and fundus autofluorescence in patients with geographic atrophy. , 2011, Ophthalmology.

[57]  Steffen Schmitz-Valckenberg,et al.  Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration. , 2011, Investigative ophthalmology & visual science.

[58]  F. Ferris,et al.  Treatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trial. , 2010, Investigative ophthalmology & visual science.

[59]  Christian Ahlers,et al.  Performance of drusen detection by spectral-domain optical coherence tomography. , 2010, Investigative ophthalmology & visual science.

[60]  Harald Sattmann,et al.  Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography. , 2010, Journal of biomedical optics.

[61]  Sina Farsiu,et al.  Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs. , 2010, Investigative ophthalmology & visual science.

[62]  Christine Adrion,et al.  Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration. , 2010, Investigative ophthalmology & visual science.

[63]  E. Agrón,et al.  Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28. , 2010, Ophthalmology.

[64]  R. Krishnan,et al.  Regression of soft drusen and drusenoid pigment epithelial detachment following intravitreal anti-vascular endothelial growth factor therapy. , 2010, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[65]  C. Curcio,et al.  Reticular pseudodrusen are subretinal drusenoid deposits. , 2010, Ophthalmology.

[66]  A. Detsky,et al.  Composite end points in randomized trials: there is no free lunch. , 2010, JAMA.

[67]  Michael D. Ober,et al.  Disappearance of drusen after rhegmatogenous retinal detachment. , 2010, Retinal cases & brief reports.

[68]  J. Izatt,et al.  Spectral domain optical coherence tomography imaging of geographic atrophy margins. , 2009, Ophthalmology.

[69]  Frederick L Ferris,et al.  Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26. , 2009, Archives of ophthalmology.

[70]  William J Feuer,et al.  Spectral domain optical coherence tomographic imaging of geographic atrophy. , 2008, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[71]  G. Virgili,et al.  Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. , 2009, The Cochrane database of systematic reviews.

[72]  Aziz A. Khanifar,et al.  Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration. , 2008, Ophthalmology.

[73]  U. Schmidt-Erfurth,et al.  Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. , 2008, Optics express.

[74]  Steffen Schmitz-Valckenberg,et al.  Evaluation of autofluorescence imaging with the scanning laser ophthalmoscope and the fundus camera in age-related geographic atrophy. , 2008, American journal of ophthalmology.

[75]  Thomas S Hwang,et al.  Retinal precursors and the development of geographic atrophy in age-related macular degeneration. , 2008, Ophthalmology.

[76]  Joseph A Izatt,et al.  CORRELATION OF PATHOLOGIC FEATURES IN SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY WITH CONVENTIONAL RETINAL STUDIES , 2008, Retina.

[77]  F. Ferris,et al.  Report from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints Symposium. , 2008, Investigative ophthalmology & visual science.

[78]  G. Ying,et al.  Risk factors for choroidal neovascularization and geographic atrophy in the complications of age-related macular degeneration prevention trial. , 2007, Ophthalmology.

[79]  Pell,et al.  Drusen Measurement from Fundus Photographs Using Computer Image Analysis , 2008 .

[80]  Frank Eperjesi,et al.  Use of fundus imaging in quantification of age-related macular change. , 2007, Survey of ophthalmology.

[81]  T. Friberg,et al.  Computerized detection and measurement of drusen in age-related macular degeneration. , 2007, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[82]  Jens Dreyhaupt,et al.  Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. , 2007, American journal of ophthalmology.

[83]  Ronald Klein,et al.  Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. , 2007, Ophthalmology.

[84]  Eyal Margalit,et al.  The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials. , 2007, Ophthalmology.

[85]  Paul Mitchell,et al.  Ten-year incidence and progression of age-related maculopathy: the blue Mountains Eye Study. , 2007, Ophthalmology.

[86]  K. Tsubota,et al.  Regression of macular drusen after pars plana vitrectomy in a patient with age-related macular degeneration. , 2007, Retinal cases & brief reports.

[87]  Johanna M Seddon,et al.  Evaluation of the clinical age-related maculopathy staging system. , 2006, Ophthalmology.

[88]  Areds Coordinating.  A simplified severity scale for age-related macular degeneration: AREDS report no.18 , 2006 .

[89]  J. Vander,et al.  The Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration: AREDS Report No 17 , 2006 .

[90]  Ronald Klein,et al.  A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. , 2005, Archives of ophthalmology.

[91]  Matthew D. Davis,et al.  The Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration , 2015 .

[92]  T. Sheidow,et al.  Prospective evaluation of digital non-stereo color fundus photography as a screening tool in age-related macular degeneration. , 2005, American journal of ophthalmology.

[93]  R T Smith,et al.  A method of drusen measurement based on reconstruction of fundus background reflectance , 2004, British Journal of Ophthalmology.

[94]  Leslie Hyman,et al.  A Simplified Severity Scale for Age-Related Macular Degeneration , 2005 .

[95]  P. Jong.  Prevalence of age-related macular degeneration in the United States. , 2004 .

[96]  Benita J. O’Colmain,et al.  Prevalence of age-related macular degeneration in the United States. , 2004, Archives of ophthalmology.

[97]  Paul Mitchell,et al.  Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. , 2003, Archives of ophthalmology.

[98]  R. Klein,et al.  Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study. , 2002, Ophthalmology.

[99]  Paul Mitchell,et al.  Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. , 2002, Ophthalmology.

[100]  Tunde Peto,et al.  Inter- and intra-observer variability in grading lesions of age-related maculopathy and macular degeneration , 2002, Graefe's Archive for Clinical and Experimental Ophthalmology.

[101]  A Hofman,et al.  Incidence and progression rates of age-related maculopathy: the Rotterdam Study. , 2001, Investigative ophthalmology & visual science.

[102]  The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. , 2001, American journal of ophthalmology.

[103]  J S Sunness,et al.  Measuring geographic atrophy in advanced age-related macular degeneration. , 1999, Investigative ophthalmology & visual science.

[104]  L. D. Del Priore,et al.  Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. , 1999, Survey of ophthalmology.

[105]  M. Killingsworth,et al.  Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study , 1999, The British journal of ophthalmology.

[106]  R. Klein,et al.  The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. , 1997, Ophthalmology.

[107]  J M Gibson,et al.  Seven year follow-up of age-related maculopathy in an elderly British population , 1997, Eye.

[108]  M G Maguire,et al.  Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study. , 1995, Archives of ophthalmology.

[109]  P T de Jong,et al.  An international classification and grading system for age-related maculopathy and age-related macular degeneration , 1995 .

[110]  R L Cooper,et al.  Automated extraction and quantification of macular drusen from fundal photographs. , 1994, Australian and New Zealand journal of ophthalmology.

[111]  R. Klein,et al.  Prevalence of age-related maculopathy. The Beaver Dam Eye Study. , 1992, Ophthalmology.

[112]  R. Klein,et al.  The Wisconsin age-related maculopathy grading system. , 1991, Ophthalmology.

[113]  Wei-Hao Wang,et al.  Studies , 1926 .