Double-stranded Let-7 mimics, potential candidates for cancer gene therapy

[1]  Keun-Hwa Jung,et al.  Let-7 microRNA inhibits the proliferation of human glioblastoma cells , 2011, Journal of Neuro-Oncology.

[2]  P. Kaiser,et al.  RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027. , 2010, American journal of ophthalmology.

[3]  Knut Reinert,et al.  Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human Genome , 2010, PLoS pathogens.

[4]  P. Linsley,et al.  The therapeutic potential of microRNA modulation. , 2010, Discovery medicine.

[5]  G. Yousef,et al.  MicroRNAs in clinical oncology: at the crossroads between promises and problems , 2009, Journal of Clinical Pathology.

[6]  Brian D Athey,et al.  New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites. , 2009, Genome research.

[7]  C. Bloomfield,et al.  MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. , 2009, Blood.

[8]  Kathryn A. O’Donnell,et al.  Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model , 2009, Cell.

[9]  Ruian Xu,et al.  Potential uses of microRNA in lung cancer diagnosis, prognosis, and therapy. , 2009, Current cancer drug targets.

[10]  L. Buscail,et al.  let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. , 2009, Human gene therapy.

[11]  Q. Pan,et al.  MicroRNA-143 as a tumor suppressor for bladder cancer. , 2009, The Journal of urology.

[12]  John J. Rossi,et al.  The promises and pitfalls of RNA-interference-based therapeutics , 2009, Nature.

[13]  Andreas Petri,et al.  MicroRNA silencing in primates: towards development of novel therapeutics. , 2009, Cancer research.

[14]  E. Olson,et al.  Toward microRNA-based therapeutics for heart disease: the sense in antisense. , 2008, Circulation research.

[15]  Brian H. Dunford-Shore,et al.  Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.

[16]  G. Parmigiani,et al.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.

[17]  N. Rajewsky,et al.  Widespread changes in protein synthesis induced by microRNAs , 2008, Nature.

[18]  D. Bartel,et al.  The impact of microRNAs on protein output , 2008, Nature.

[19]  Y. Diao,et al.  The design of vectors for RNAi delivery system. , 2008, Current pharmaceutical design.

[20]  J. Melamed,et al.  Antiproliferative Effects by Let-7 Repression of High-Mobility Group A2 in Uterine Leiomyoma , 2008, Molecular Cancer Research.

[21]  F. Slack,et al.  The let-7 microRNA reduces tumor growth in mouse models of lung cancer , 2008, Cell cycle.

[22]  Phillip A Sharp,et al.  Suppression of non-small cell lung tumor development by the let-7 microRNA family , 2008, Proceedings of the National Academy of Sciences.

[23]  L. Lim,et al.  MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression , 2008, Molecular and Cellular Biology.

[24]  W. Gerald,et al.  Endogenous human microRNAs that suppress breast cancer metastasis , 2008, Nature.

[25]  Sreenath V. Sharma,et al.  Oncogene addiction: setting the stage for molecularly targeted cancer therapy. , 2007, Genes & development.

[26]  J. Lieberman,et al.  let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells , 2007, Cell.

[27]  Imran Babar,et al.  MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. , 2007, Cancer research.

[28]  Y. Ishikawa,et al.  let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a non-invasive carcinoma, and is not correlated with prognosis. , 2007, Lung cancer.

[29]  Patricia Soteropoulos,et al.  MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. , 2007, Cancer research.

[30]  G. Calin,et al.  miRNAs and their potential for use against cancer and other diseases. , 2007, Future oncology.

[31]  Stanley T. Crooke,et al.  Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells , 2007, Nucleic acids research.

[32]  S. Elledge,et al.  Non-Oncogene Addiction and the Stress Phenotype of Cancer Cells , 2007, Cell.

[33]  T Takahashi,et al.  Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92 , 2007, Oncogene.

[34]  F. Slack,et al.  The let-7 microRNA represses cell proliferation pathways in human cells. , 2007, Cancer research.

[35]  Anne Gatignol,et al.  Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC , 2007, Nucleic acids research.

[36]  E. Kistner,et al.  Let-7 expression defines two differentiation stages of cancer , 2007, Proceedings of the National Academy of Sciences.

[37]  Anindya Dutta,et al.  The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. , 2007, Genes & development.

[38]  N. Dean,et al.  Competition for RISC binding predicts in vitro potency of siRNA , 2006, Nucleic acids research.

[39]  Y. Akao,et al.  let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. , 2006, Biological & pharmaceutical bulletin.

[40]  R. Stephens,et al.  Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. , 2006, Cancer cell.

[41]  J. Rasko,et al.  Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response , 2006, Nature Medicine.

[42]  Z. Mourelatos,et al.  A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. , 2005, Genes & development.

[43]  R. Shiekhattar,et al.  Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing , 2005, Cell.

[44]  N. Tsuda,et al.  Synthetic microRNA and double-stranded RNA targeting the 3'-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells. , 2005, International journal of oncology.

[45]  Chun Xing Li,et al.  Differential expression of components of the microRNA machinery during mouse organogenesis. , 2005, Biochemical and biophysical research communications.

[46]  W. Filipowicz,et al.  Post-transcriptional gene silencing by siRNAs and miRNAs. , 2005, Current opinion in structural biology.

[47]  K. Rajewsky,et al.  Efficiency of RNA Interference in the Mouse Hematopoietic System Varies between Cell Types and Developmental Stages , 2005, Molecular and Cellular Biology.

[48]  F. Slack,et al.  RAS Is Regulated by the let-7 MicroRNA Family , 2005, Cell.

[49]  Y. Yatabe,et al.  Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival , 2004, Cancer Research.

[50]  T. Du,et al.  Asymmetry in the Assembly of the RNAi Enzyme Complex , 2003, Cell.

[51]  Shinsei Minoshima,et al.  Identification of eight members of the Argonaute family in the human genome. , 2003, Genomics.

[52]  B. Cullen,et al.  MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Phillip A Sharp,et al.  siRNAs can function as miRNAs , 2003 .

[54]  Xu Ruian,et al.  Mutant K-ras-specific siRNA inhibits proliferation,migration and induces apoptosis of lung cancer A549 cells , 2009 .

[55]  I. Martins,et al.  Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[56]  S. Elledge,et al.  Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction , 2009, Cell.

[57]  J. Uhm.  An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2009 .

[58]  A. Joe,et al.  Oncogene addiction. , 2008, Cancer research.

[59]  Anastasia Khvorova,et al.  Functional siRNAs and miRNAs Exhibit Strand Bias , 2003, Cell.