White Matter Lesions in a Patient With Creutzfeldt-Jakob Disease

This is a report of a patient with Creutzfeldt-Jakob disease. The 67-year-old male first developed partial and secondary generalized tonic-clonic seizures. He was disoriented and could not perform calculations nor recall objects shown to him 5 minutes earlier. Magnetic resonance images revealed hyperintensities of white matter lesions in fluid-attenuated inversion recovery weighted image. We detected protein 14-3-3 in the cerebrospinal fluid.

[1]  A. Rozemuller,et al.  Panencephalopathic Creutzfeldt–Jakob disease in the Netherlands and the UK: clinical and pathological characteristics of nine patients , 2009, Neuropathology and applied neurobiology.

[2]  S. Han,et al.  Periodic Sharp Wave Complexes observed by Repetitive EEGs in a Patient with Probable Sporadic Creutzfeldt-Jacob Disease , 2006 .

[3]  松末 英司.  White matter lesions in panencephalopathic type of Creutzfeldt-Jakob disease : MR imaging and pathologic correlations , 2005 .

[4]  P. Deyn,et al.  Differential diagnosis of 201 possible Creutzfeldt-Jakob disease patients , 2004, Journal of Neurology.

[5]  A. Colchester,et al.  MRI of Creutzfeldt-Jakob disease: imaging features and recommended MRI protocol. , 2001, Clinical radiology.

[6]  R. Zimmerman,et al.  Rapid spongiform degeneration of the cerebrum and cerebellum in Creutzfeldt-Jakob encephalitis: serial MR findings. , 1997, AJNR. American journal of neuroradiology.

[7]  H. Mertens,et al.  Panencephalopathic type of Creutzfeldt-Jakob disease with primary extensive involvement of white matter. , 1990, European neurology.

[8]  C. Sigurdson,et al.  [Prion diseases?]. , 1985, Deutsche medizinische Wochenschrift.

[9]  G. Macchi,et al.  On the white matter lesions of the Creutzfeldt-Jakob disease Can a new subentity be recognized in man? , 1984, Journal of the Neurological Sciences.

[10]  T. Mizutani,et al.  Panencephalopathic type of Creutzfeldt-Jakob disease: primary involvement of the cerebral white matter , 1981, Journal of neurology, neurosurgery, and psychiatry.