Clinical significance of preoperative antibiotic use in mild to moderate acute inflammatory gallbladder disease: A randomized controlled trial

Many patients receive empirical antibiotics for the prevention of postoperative infectious complications following cholecystectomy due to acute cholecystitis (AC). The purpose of this study was to investigate the clinical significance of preoperative antibiotics in mild to moderate AC patients undergoing emergency laparoscopic cholecystectomy.

[1]  T. Hong,et al.  Empirical Antibiotics for Acute Cholecystitis - What Generation of Antibiotics is an Appropriate Choice? A prospective, randomized controlled study. , 2021, Journal of hepato-biliary-pancreatic sciences.

[2]  K. Slim,et al.  Are the recommendations for post-operative antibiotics in patients with grade I or II acute calculous cholecystitis being applied in clinical practice? , 2020, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[3]  S. Hajibandeh,et al.  Extended Postoperative Antibiotics Versus No Postoperative Antibiotics in Patients Undergoing Emergency Cholecystectomy for Acute Calculous Cholecystitis: A Systematic Review and Meta-Analysis , 2019, Surgical innovation.

[4]  M. Ceppi,et al.  Antibiotic administration after cholecystectomy for acute mild-moderate cholecystitis: a PRISMA-compliant meta-analysis , 2018, Surgical Endoscopy.

[5]  V. Ardiles,et al.  Extended antibiotic therapy versus placebo after laparoscopic cholecystectomy for mild and moderate acute calculous cholecystitis: A randomized double‐blind clinical trial☆ , 2018, Surgery.

[6]  D. Gouma,et al.  Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis , 2018, Journal of hepato-biliary-pancreatic sciences.

[7]  D. Gouma,et al.  Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis , 2018, Journal of hepato-biliary-pancreatic sciences.

[8]  Y. Yoon,et al.  Is there a real role of postoperative antibiotic administration for mildmoderate acute cholecystitis? A prospective randomized controlled trial , 2017, Journal of hepato-biliary-pancreatic sciences.

[9]  G. Nieuwenhuijzen,et al.  Perioperative antibiotic prophylaxis in the treatment of acute cholecystitis (PEANUTS II trial): study protocol for a randomized controlled trial , 2017, Trials.

[10]  N. Demartines,et al.  Early Versus Delayed Cholecystectomy for Acute Cholecystitis, Are the 72 hours Still the Rule?: A Randomized Trial , 2016, Annals of surgery.

[11]  M. Boermeester,et al.  Systematic review of antibiotic treatment for acute calculous cholecystitis , 2016, The British journal of surgery.

[12]  Chiung‐Yu Chen,et al.  Assessing clinical outcomes of patients with acute calculous cholecystitis in addition to the Tokyo grading: A retrospective study , 2014, The Kaohsiung journal of medical sciences.

[13]  S. Msika,et al.  Effect of postoperative antibiotic administration on postoperative infection following cholecystectomy for acute calculous cholecystitis: a randomized clinical trial. , 2014, JAMA.

[14]  Atilla Halil Elhan,et al.  Does Adjuvant Antibiotic Treatment After Drainage of Anorectal Abscess Prevent Development of Anal Fistulas? A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study , 2011, Diseases of the colon and rectum.

[15]  E. P. Dellinger,et al.  Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  M. Kelly,et al.  Laparoscopic retrograde (fundus first) cholecystectomy , 2009, BMC surgery.

[17]  I. Matter,et al.  The effect of bactibilia on the course and outcome of laparoscopic cholecystectomy , 2008, European Journal of Clinical Microbiology & Infectious Diseases.

[18]  Masahiro Yoshida,et al.  Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines , 2007, Journal of hepato-biliary-pancreatic surgery.